TY - JOUR
T1 - Lacidipine porous tablets
T2 - Formulation and in vitro characterization
AU - Estibeiro, Astrilia L.
AU - Harmalkar, Divya
AU - Godinho, Soraiya
AU - Kumar, Lalit
AU - Shirodkar, Rupesh K.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Lacidipine (LCDP), a BCS class II drug is used in the treatment of hypertension. Upon oral administration, LCDP shows poor absorption from gastrointestinal tract and undergoes extensive first pass hepatic metabolism. The oral bioavailability of LCDP is 10%. The present study involved the development and characterization of LCDP porous tablets to enhance its solubility and dissolution rate. Tablets were formulated by direct compression method followed by vacuum drying at 40 °C for 6 h. Optimized formulation contained croscarmellose sodium as superdisintegrants and camphor as sublimating agent. Tablets were characterized for post compression parameters. Dissolution was carried out in phosphate buffer pH 6.8 and in pH 1.2 buffer with 0.2% Tween 20. Scanning electron microscopy image revealed the presence of highly porous surface texture. Thus, collectively it can be concluded that porous tablets of LCDP can serve as an alternative for enhancement of drug solubility and release thereby enhancing its bioavailability.
AB - Lacidipine (LCDP), a BCS class II drug is used in the treatment of hypertension. Upon oral administration, LCDP shows poor absorption from gastrointestinal tract and undergoes extensive first pass hepatic metabolism. The oral bioavailability of LCDP is 10%. The present study involved the development and characterization of LCDP porous tablets to enhance its solubility and dissolution rate. Tablets were formulated by direct compression method followed by vacuum drying at 40 °C for 6 h. Optimized formulation contained croscarmellose sodium as superdisintegrants and camphor as sublimating agent. Tablets were characterized for post compression parameters. Dissolution was carried out in phosphate buffer pH 6.8 and in pH 1.2 buffer with 0.2% Tween 20. Scanning electron microscopy image revealed the presence of highly porous surface texture. Thus, collectively it can be concluded that porous tablets of LCDP can serve as an alternative for enhancement of drug solubility and release thereby enhancing its bioavailability.
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M3 - Article
AN - SCOPUS:85053789036
SN - 0326-2383
VL - 37
SP - 1764
EP - 1771
JO - Latin American Journal of Pharmacy
JF - Latin American Journal of Pharmacy
IS - 9
ER -