Lamotrigine Lipid Nanoparticles for Effective Treatment of Epilepsy

a Focus on Brain Targeting via Nasal Route

Puja K. Gangurde, Navya Ajitkumar B, Lalit Kumar

Research output: Contribution to journalReview article

Abstract

Background: Pharmaceutical research in the field of medicine aims to improve the quality of life of a patient. Epilepsy is a neurological disorder affecting a number of patients worldwide because of poor penetration of antiepileptic drugs across the blood brain barrier. Therefore, there is a need to find an alternative drug delivery technology to overcome problems associated with conventional therapy. Objective: The aim of this review is to introduce and understand the importance of targeting lamotrigine to the brain via the nasal route. Mechanism of drug transport via nasal cavity to brain and various strategies to improve drug absorption through nasal cavity. Methods: Existing route of drug administration of lamotrigine is oral route. The route that has been rarely explored for lamotrigine targeting to the brain such as nasal route of drug administration is focused in this article. Results: Nanomedicine has gained a lot of importance in the recent past. Many studies have been taken up to deliver drugs to the brain as nanoparticles. In most of the approaches, efforts were made to deliver the nanoparticles either by the oral route or intravenous route of administration. In the present review, we have discussed the current outlook on advances in brain targeting by administration of drug via the nasal route. Conclusion: Targeting lamotrigine via the nasal route to the brain is a promising delivery system and would be advantageous in the treatment of other poorly bioavailable drugs to treat disorders of the brain.

Original languageEnglish
Pages (from-to)91-111
Number of pages21
JournalJournal of Pharmaceutical Innovation
Volume14
Issue number2
DOIs
Publication statusPublished - 15-06-2019

Fingerprint

Nose
Nanoparticles
Epilepsy
Lipids
Brain
Drug Administration Routes
Pharmaceutical Preparations
Nasal Cavity
Therapeutics
Nanomedicine
Brain Diseases
Drug Delivery Systems
Nervous System Diseases
Blood-Brain Barrier
Intravenous Administration
Anticonvulsants
lamotrigine
Quality of Life
Medicine
Technology

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery

Cite this

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title = "Lamotrigine Lipid Nanoparticles for Effective Treatment of Epilepsy: a Focus on Brain Targeting via Nasal Route",
abstract = "Background: Pharmaceutical research in the field of medicine aims to improve the quality of life of a patient. Epilepsy is a neurological disorder affecting a number of patients worldwide because of poor penetration of antiepileptic drugs across the blood brain barrier. Therefore, there is a need to find an alternative drug delivery technology to overcome problems associated with conventional therapy. Objective: The aim of this review is to introduce and understand the importance of targeting lamotrigine to the brain via the nasal route. Mechanism of drug transport via nasal cavity to brain and various strategies to improve drug absorption through nasal cavity. Methods: Existing route of drug administration of lamotrigine is oral route. The route that has been rarely explored for lamotrigine targeting to the brain such as nasal route of drug administration is focused in this article. Results: Nanomedicine has gained a lot of importance in the recent past. Many studies have been taken up to deliver drugs to the brain as nanoparticles. In most of the approaches, efforts were made to deliver the nanoparticles either by the oral route or intravenous route of administration. In the present review, we have discussed the current outlook on advances in brain targeting by administration of drug via the nasal route. Conclusion: Targeting lamotrigine via the nasal route to the brain is a promising delivery system and would be advantageous in the treatment of other poorly bioavailable drugs to treat disorders of the brain.",
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Lamotrigine Lipid Nanoparticles for Effective Treatment of Epilepsy : a Focus on Brain Targeting via Nasal Route. / Gangurde, Puja K.; Ajitkumar B, Navya; Kumar, Lalit.

In: Journal of Pharmaceutical Innovation, Vol. 14, No. 2, 15.06.2019, p. 91-111.

Research output: Contribution to journalReview article

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