Langerhans cell histiocytosis presenting as hypothyroid goitre

A unique presentation

Krishna Chaitanya Marupudi, Suman S. Karanth, Joseph Thomas

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Langerhans cell histiocytosis (LCH) is a disease involving the antigen presenting cells, which can range from a single system involvement with an indolent course to a multisystem disease with increased morbidity. We present a rare case of LCH presenting as hypothyroid goitre that was successfully treated as per the LCH III trial protocol with a combination of vinblastine and oral prednisolone. We highlight the need for awareness of this rare presentation of LCH as a painless goitre which is often misdiagnosed as poorly differentiated thyroid carcinoma or overlooked as a benign disease.

Original languageEnglish
Article number206760
JournalBMJ Case Reports
Volume2014
DOIs
Publication statusPublished - 02-12-2014

Fingerprint

Langerhans Cell Histiocytosis
Goiter
Vinblastine
Antigen-Presenting Cells
Clinical Protocols
Prednisolone
Diagnostic Errors
Thyroid Neoplasms
Morbidity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Marupudi, Krishna Chaitanya ; Karanth, Suman S. ; Thomas, Joseph. / Langerhans cell histiocytosis presenting as hypothyroid goitre : A unique presentation. In: BMJ Case Reports. 2014 ; Vol. 2014.
@article{9f7c4291964e449787dd261ba4d07dbf,
title = "Langerhans cell histiocytosis presenting as hypothyroid goitre: A unique presentation",
abstract = "Langerhans cell histiocytosis (LCH) is a disease involving the antigen presenting cells, which can range from a single system involvement with an indolent course to a multisystem disease with increased morbidity. We present a rare case of LCH presenting as hypothyroid goitre that was successfully treated as per the LCH III trial protocol with a combination of vinblastine and oral prednisolone. We highlight the need for awareness of this rare presentation of LCH as a painless goitre which is often misdiagnosed as poorly differentiated thyroid carcinoma or overlooked as a benign disease.",
author = "Marupudi, {Krishna Chaitanya} and Karanth, {Suman S.} and Joseph Thomas",
year = "2014",
month = "12",
day = "2",
doi = "10.1136/bcr-2014-206760",
language = "English",
volume = "2014",
journal = "BMJ Case Reports",
issn = "1757-790X",
publisher = "BMJ Publishing Group",

}

Langerhans cell histiocytosis presenting as hypothyroid goitre : A unique presentation. / Marupudi, Krishna Chaitanya; Karanth, Suman S.; Thomas, Joseph.

In: BMJ Case Reports, Vol. 2014, 206760, 02.12.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Langerhans cell histiocytosis presenting as hypothyroid goitre

T2 - A unique presentation

AU - Marupudi, Krishna Chaitanya

AU - Karanth, Suman S.

AU - Thomas, Joseph

PY - 2014/12/2

Y1 - 2014/12/2

N2 - Langerhans cell histiocytosis (LCH) is a disease involving the antigen presenting cells, which can range from a single system involvement with an indolent course to a multisystem disease with increased morbidity. We present a rare case of LCH presenting as hypothyroid goitre that was successfully treated as per the LCH III trial protocol with a combination of vinblastine and oral prednisolone. We highlight the need for awareness of this rare presentation of LCH as a painless goitre which is often misdiagnosed as poorly differentiated thyroid carcinoma or overlooked as a benign disease.

AB - Langerhans cell histiocytosis (LCH) is a disease involving the antigen presenting cells, which can range from a single system involvement with an indolent course to a multisystem disease with increased morbidity. We present a rare case of LCH presenting as hypothyroid goitre that was successfully treated as per the LCH III trial protocol with a combination of vinblastine and oral prednisolone. We highlight the need for awareness of this rare presentation of LCH as a painless goitre which is often misdiagnosed as poorly differentiated thyroid carcinoma or overlooked as a benign disease.

UR - http://www.scopus.com/inward/record.url?scp=84919372709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919372709&partnerID=8YFLogxK

U2 - 10.1136/bcr-2014-206760

DO - 10.1136/bcr-2014-206760

M3 - Article

VL - 2014

JO - BMJ Case Reports

JF - BMJ Case Reports

SN - 1757-790X

M1 - 206760

ER -