Laxative activity of spray dired aqueous seed extract Linum usitatissimum

B.S. Ashok Kumar, V. Prabhakar, K. Lakshman, V.B. Narayana Swamy

Research output: Contribution to journalArticle

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Abstract

Aqueous extract of Linum usitatissimum Linn, (Linaceae) was evaluated for laxative activity in rats at three dose levels (12.5, 25, 50 mg/kg). Healthy Wister rats were divided into 4 groups of 6 animals each. First group served as control, second group served as standard (Senna) while 3 and 4 groups were treated with aqueous extract of Linum usitatissimum (12.5 and 25 mg/kg body weight) respectively. The laxative activity was determined based on the weight of the faecal matter at time interval of 8 and 16th h. Gastrointestinal motility was studied by using charcoal meal method. Both the studies showed increase in laxative activity and gastrointestinal motility at 25 mg/kg dose of L. usitatissimum.
Original languageEnglish
Pages (from-to)371-378
Number of pages8
JournalPharmacologyonline
Volume1
Publication statusPublished - 2007
Externally publishedYes

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Flax
Laxatives
Seeds
Gastrointestinal Motility
Linaceae
Charcoal
Meals
Body Weight
Weights and Measures
Control Groups

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Ashok Kumar, B. S., Prabhakar, V., Lakshman, K., & Narayana Swamy, V. B. (2007). Laxative activity of spray dired aqueous seed extract Linum usitatissimum. Pharmacologyonline, 1, 371-378.
Ashok Kumar, B.S. ; Prabhakar, V. ; Lakshman, K. ; Narayana Swamy, V.B. / Laxative activity of spray dired aqueous seed extract Linum usitatissimum. In: Pharmacologyonline. 2007 ; Vol. 1. pp. 371-378.
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abstract = "Aqueous extract of Linum usitatissimum Linn, (Linaceae) was evaluated for laxative activity in rats at three dose levels (12.5, 25, 50 mg/kg). Healthy Wister rats were divided into 4 groups of 6 animals each. First group served as control, second group served as standard (Senna) while 3 and 4 groups were treated with aqueous extract of Linum usitatissimum (12.5 and 25 mg/kg body weight) respectively. The laxative activity was determined based on the weight of the faecal matter at time interval of 8 and 16th h. Gastrointestinal motility was studied by using charcoal meal method. Both the studies showed increase in laxative activity and gastrointestinal motility at 25 mg/kg dose of L. usitatissimum.",
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note = "Export Date: 10 November 2017 Correspondence Address: Ashok Kumar, B.S.; Department of Pharmacognosy, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India; email: ashok4vani@rediffmail.com Chemicals/CAS: charcoal, 16291-96-6 References: Kapoor, L.D., (1990) Handbook of Ayurvedic medicinal plants, p. 217. , Boca Raton: CRC press; Nadkarni KM, Nadkarni AK. Indian Materia Medica, I, 3rd edn. M/s Popular Prakashan Pvt, Ltd., Bombay, 1999; p 743-746; Carlson, C., The Benefits of Flax (1998) Herbs for Health, pp. 63-65. , Sept /Oct; British Herbal Pharmacopoeia (BHP). Exerter, U.K.: British Herbal medicine Association, Lavoisier Publishing, Paris 1996; Secoisolariciresinol, P.K., Diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat (2001) Journal of Laboratory Clinical Medicine, 138 (1), pp. 32-39; Taber's, T.C.W., (1962) Cyclopedic Medical Dictionary, pp. F-21. , 9th edn. Philadelphia: FA, Davis Company; Tu, G., (1992) Pharmacopoeia of the People's Republic of China, , Beijing; Guangdong Science and Technology Press; Budavari S. The Merck Index: An Encyclopedia of chemicals, Drugs and Biologicals, 12th edn. Whitehouse station, N.J.: Merck and Co, Inc; 1996; Lini semen (1997) Monographs on the medicinal uses of plant drugs, , ESCOP European Scientific Cooperative on Phytotheraphy, Exeter, U.K; Cunnane, S.C., Nutritional attributes of traditional flaxseed in healthy young adults (1994) American Journal Clinical Nutrition, 61, pp. 62-68; Kirtikar, K.R., Basu, B.D., Linum usitatissimum (1987) Indian medicinal plants, 3, pp. 408-409. , 2nd ed. International book distributors, Dehra Dun, India; Karnick CR. Pharmacopoeial Standards of Herbal Plants, 1-2. Delhi: Sri Satguru Publications. 1994;I: 228-229; II: 55; Simopoulos, A.P., Omega-3 fatty acids in inflammation and autoimmune diseases (2002) Journal of American Coll Nutrition, 21 (6), pp. 495-505; Capasso, F., Mascolo, N., Autore, G., Romano, V., (1986) Journal of Pharmaceutical Pharmacology, 13, p. 627; Ganapaty, S., Subburaju, T., Dash, G.K., Suresh, B., Diuretic, Laxative and Toxicity studies of Cocculus hirsutus aerial parts (2002) Fitoterapia, 73, pp. 28-31; Akah PA, OriSakwe OE, Gamaniel KS, and Shittu A. Evaluation of Nigerian traditional medicines: Effects of some Nigerian folk remedies on peptic ulcer. J.of ethnopharmacology.1998; 62, p123-127; Goodman, Gilmann, (2001) The Pharmacological Basis of Therapeutics, pp. 1045-1046. , 10th edn. McGraw-Hill, Medical Publishing Division, New York; Blumenthal, M., Expanded Commission E Monographs (2000) Boston mass, pp. 134-138. , 1st edn, Integrative Medicine Communications",
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Ashok Kumar, BS, Prabhakar, V, Lakshman, K & Narayana Swamy, VB 2007, 'Laxative activity of spray dired aqueous seed extract Linum usitatissimum', Pharmacologyonline, vol. 1, pp. 371-378.

Laxative activity of spray dired aqueous seed extract Linum usitatissimum. / Ashok Kumar, B.S.; Prabhakar, V.; Lakshman, K.; Narayana Swamy, V.B.

In: Pharmacologyonline, Vol. 1, 2007, p. 371-378.

Research output: Contribution to journalArticle

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N1 - Export Date: 10 November 2017 Correspondence Address: Ashok Kumar, B.S.; Department of Pharmacognosy, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India; email: ashok4vani@rediffmail.com Chemicals/CAS: charcoal, 16291-96-6 References: Kapoor, L.D., (1990) Handbook of Ayurvedic medicinal plants, p. 217. , Boca Raton: CRC press; Nadkarni KM, Nadkarni AK. Indian Materia Medica, I, 3rd edn. M/s Popular Prakashan Pvt, Ltd., Bombay, 1999; p 743-746; Carlson, C., The Benefits of Flax (1998) Herbs for Health, pp. 63-65. , Sept /Oct; British Herbal Pharmacopoeia (BHP). Exerter, U.K.: British Herbal medicine Association, Lavoisier Publishing, Paris 1996; Secoisolariciresinol, P.K., Diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat (2001) Journal of Laboratory Clinical Medicine, 138 (1), pp. 32-39; Taber's, T.C.W., (1962) Cyclopedic Medical Dictionary, pp. F-21. , 9th edn. Philadelphia: FA, Davis Company; Tu, G., (1992) Pharmacopoeia of the People's Republic of China, , Beijing; Guangdong Science and Technology Press; Budavari S. The Merck Index: An Encyclopedia of chemicals, Drugs and Biologicals, 12th edn. Whitehouse station, N.J.: Merck and Co, Inc; 1996; Lini semen (1997) Monographs on the medicinal uses of plant drugs, , ESCOP European Scientific Cooperative on Phytotheraphy, Exeter, U.K; Cunnane, S.C., Nutritional attributes of traditional flaxseed in healthy young adults (1994) American Journal Clinical Nutrition, 61, pp. 62-68; Kirtikar, K.R., Basu, B.D., Linum usitatissimum (1987) Indian medicinal plants, 3, pp. 408-409. , 2nd ed. International book distributors, Dehra Dun, India; Karnick CR. Pharmacopoeial Standards of Herbal Plants, 1-2. Delhi: Sri Satguru Publications. 1994;I: 228-229; II: 55; Simopoulos, A.P., Omega-3 fatty acids in inflammation and autoimmune diseases (2002) Journal of American Coll Nutrition, 21 (6), pp. 495-505; Capasso, F., Mascolo, N., Autore, G., Romano, V., (1986) Journal of Pharmaceutical Pharmacology, 13, p. 627; Ganapaty, S., Subburaju, T., Dash, G.K., Suresh, B., Diuretic, Laxative and Toxicity studies of Cocculus hirsutus aerial parts (2002) Fitoterapia, 73, pp. 28-31; Akah PA, OriSakwe OE, Gamaniel KS, and Shittu A. Evaluation of Nigerian traditional medicines: Effects of some Nigerian folk remedies on peptic ulcer. J.of ethnopharmacology.1998; 62, p123-127; Goodman, Gilmann, (2001) The Pharmacological Basis of Therapeutics, pp. 1045-1046. , 10th edn. McGraw-Hill, Medical Publishing Division, New York; Blumenthal, M., Expanded Commission E Monographs (2000) Boston mass, pp. 134-138. , 1st edn, Integrative Medicine Communications

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AB - Aqueous extract of Linum usitatissimum Linn, (Linaceae) was evaluated for laxative activity in rats at three dose levels (12.5, 25, 50 mg/kg). Healthy Wister rats were divided into 4 groups of 6 animals each. First group served as control, second group served as standard (Senna) while 3 and 4 groups were treated with aqueous extract of Linum usitatissimum (12.5 and 25 mg/kg body weight) respectively. The laxative activity was determined based on the weight of the faecal matter at time interval of 8 and 16th h. Gastrointestinal motility was studied by using charcoal meal method. Both the studies showed increase in laxative activity and gastrointestinal motility at 25 mg/kg dose of L. usitatissimum.

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Ashok Kumar BS, Prabhakar V, Lakshman K, Narayana Swamy VB. Laxative activity of spray dired aqueous seed extract Linum usitatissimum. Pharmacologyonline. 2007;1:371-378.