Laxative activity of spray dired aqueous seed extract Linum usitatissimum

B.S. Ashok Kumar, V. Prabhakar, K. Lakshman, V.B. Narayana Swamy

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Abstract

Aqueous extract of Linum usitatissimum Linn, (Linaceae) was evaluated for laxative activity in rats at three dose levels (12.5, 25, 50 mg/kg). Healthy Wister rats were divided into 4 groups of 6 animals each. First group served as control, second group served as standard (Senna) while 3 and 4 groups were treated with aqueous extract of Linum usitatissimum (12.5 and 25 mg/kg body weight) respectively. The laxative activity was determined based on the weight of the faecal matter at time interval of 8 and 16th h. Gastrointestinal motility was studied by using charcoal meal method. Both the studies showed increase in laxative activity and gastrointestinal motility at 25 mg/kg dose of L. usitatissimum.
Original languageEnglish
Pages (from-to)371-378
Number of pages8
JournalPharmacologyonline
Volume1
Publication statusPublished - 2007
Externally publishedYes

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Ashok Kumar, B. S., Prabhakar, V., Lakshman, K., & Narayana Swamy, V. B. (2007). Laxative activity of spray dired aqueous seed extract Linum usitatissimum. Pharmacologyonline, 1, 371-378.