Aqueous extract of Linum usitatissimum Linn, (Linaceae) was evaluated for laxative activity in rats at three dose levels (12.5, 25, 50 mg/kg). Healthy Wister rats were divided into 4 groups of 6 animals each. First group served as control, second group served as standard (Senna) while 3 and 4 groups were treated with aqueous extract of Linum usitatissimum (12.5 and 25 mg/kg body weight) respectively. The laxative activity was determined based on the weight of the faecal matter at time interval of 8 and 16th h. Gastrointestinal motility was studied by using charcoal meal method. Both the studies showed increase in laxative activity and gastrointestinal motility at 25 mg/kg dose of L. usitatissimum.
|Number of pages||8|
|Publication status||Published - 2007|