Lessons from melanocyte development for understanding the biological events in naevus melanoma formation

M. Herlyn, C. Barking, G. Li, K. Satyamoorthy

    Research output: Contribution to journalArticle

    75 Citations (Scopus)

    Abstract

    Recent advances in mouse genetics have identified molecular changes that are critical for melanocyte maturation and differentiation. This review briefly summarizes the current knowledge of distinct steps in melanocyte development, and identifies for each step the most important molecules such as the growth factors stem cell factor and endothelin-3, with their respective receptors. Classical cadherins, i.e. E-cadherin, N-cadherin and P-cadherin, determine melanocyte positioning in the skin. During naevus and melanoma development, the two growth factor signalling pathways are downregulated, whereas cadherin expression shifts concomitantly with re-positioning of the naevus and melanoma cells in the skin. Loss of E-cadherin and gain of N-cadherin by melanoma cells has profound consequences for the regulatory cross-talk between various types of cells in the skin. Naevus and melanoma cells that do not express E-cadherin are resistant to control by keratinocytes and establish close communications with fibroblasts and endothelial cells. However, forced expression of E-cadherin in melanoma cells can reverse the malignant phenotype by re-establishing the control of keratinocytes over the melanoma cells. Even highly aggressive metastatic melanoma cells can be signalled to turn off the expression of genes associated with tumour invasion and metastasis, suggesting that this strategy could be utilized in the therapy of melanoma. (C) 2000 Lippincott Williams and Wilkins.

    Original languageEnglish
    Pages (from-to)303-312
    Number of pages10
    JournalMelanoma Research
    Volume10
    Issue number4
    Publication statusPublished - 2000

    Fingerprint

    Nevi and Melanomas
    Melanocytes
    Cadherins
    Melanoma
    Keratinocytes
    Skin
    Intercellular Signaling Peptides and Proteins
    Endothelin-3
    Stem Cell Factor
    Down-Regulation
    Endothelial Cells
    Fibroblasts
    Communication
    Neoplasm Metastasis
    Phenotype
    Gene Expression

    All Science Journal Classification (ASJC) codes

    • Cancer Research
    • Dermatology

    Cite this

    @article{f1e3975c1d334ca8906cadbe7126153b,
    title = "Lessons from melanocyte development for understanding the biological events in naevus melanoma formation",
    abstract = "Recent advances in mouse genetics have identified molecular changes that are critical for melanocyte maturation and differentiation. This review briefly summarizes the current knowledge of distinct steps in melanocyte development, and identifies for each step the most important molecules such as the growth factors stem cell factor and endothelin-3, with their respective receptors. Classical cadherins, i.e. E-cadherin, N-cadherin and P-cadherin, determine melanocyte positioning in the skin. During naevus and melanoma development, the two growth factor signalling pathways are downregulated, whereas cadherin expression shifts concomitantly with re-positioning of the naevus and melanoma cells in the skin. Loss of E-cadherin and gain of N-cadherin by melanoma cells has profound consequences for the regulatory cross-talk between various types of cells in the skin. Naevus and melanoma cells that do not express E-cadherin are resistant to control by keratinocytes and establish close communications with fibroblasts and endothelial cells. However, forced expression of E-cadherin in melanoma cells can reverse the malignant phenotype by re-establishing the control of keratinocytes over the melanoma cells. Even highly aggressive metastatic melanoma cells can be signalled to turn off the expression of genes associated with tumour invasion and metastasis, suggesting that this strategy could be utilized in the therapy of melanoma. (C) 2000 Lippincott Williams and Wilkins.",
    author = "M. Herlyn and C. Barking and G. Li and K. Satyamoorthy",
    year = "2000",
    language = "English",
    volume = "10",
    pages = "303--312",
    journal = "Melanoma Research",
    issn = "0960-8931",
    publisher = "Lippincott Williams and Wilkins",
    number = "4",

    }

    Lessons from melanocyte development for understanding the biological events in naevus melanoma formation. / Herlyn, M.; Barking, C.; Li, G.; Satyamoorthy, K.

    In: Melanoma Research, Vol. 10, No. 4, 2000, p. 303-312.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Lessons from melanocyte development for understanding the biological events in naevus melanoma formation

    AU - Herlyn, M.

    AU - Barking, C.

    AU - Li, G.

    AU - Satyamoorthy, K.

    PY - 2000

    Y1 - 2000

    N2 - Recent advances in mouse genetics have identified molecular changes that are critical for melanocyte maturation and differentiation. This review briefly summarizes the current knowledge of distinct steps in melanocyte development, and identifies for each step the most important molecules such as the growth factors stem cell factor and endothelin-3, with their respective receptors. Classical cadherins, i.e. E-cadherin, N-cadherin and P-cadherin, determine melanocyte positioning in the skin. During naevus and melanoma development, the two growth factor signalling pathways are downregulated, whereas cadherin expression shifts concomitantly with re-positioning of the naevus and melanoma cells in the skin. Loss of E-cadherin and gain of N-cadherin by melanoma cells has profound consequences for the regulatory cross-talk between various types of cells in the skin. Naevus and melanoma cells that do not express E-cadherin are resistant to control by keratinocytes and establish close communications with fibroblasts and endothelial cells. However, forced expression of E-cadherin in melanoma cells can reverse the malignant phenotype by re-establishing the control of keratinocytes over the melanoma cells. Even highly aggressive metastatic melanoma cells can be signalled to turn off the expression of genes associated with tumour invasion and metastasis, suggesting that this strategy could be utilized in the therapy of melanoma. (C) 2000 Lippincott Williams and Wilkins.

    AB - Recent advances in mouse genetics have identified molecular changes that are critical for melanocyte maturation and differentiation. This review briefly summarizes the current knowledge of distinct steps in melanocyte development, and identifies for each step the most important molecules such as the growth factors stem cell factor and endothelin-3, with their respective receptors. Classical cadherins, i.e. E-cadherin, N-cadherin and P-cadherin, determine melanocyte positioning in the skin. During naevus and melanoma development, the two growth factor signalling pathways are downregulated, whereas cadherin expression shifts concomitantly with re-positioning of the naevus and melanoma cells in the skin. Loss of E-cadherin and gain of N-cadherin by melanoma cells has profound consequences for the regulatory cross-talk between various types of cells in the skin. Naevus and melanoma cells that do not express E-cadherin are resistant to control by keratinocytes and establish close communications with fibroblasts and endothelial cells. However, forced expression of E-cadherin in melanoma cells can reverse the malignant phenotype by re-establishing the control of keratinocytes over the melanoma cells. Even highly aggressive metastatic melanoma cells can be signalled to turn off the expression of genes associated with tumour invasion and metastasis, suggesting that this strategy could be utilized in the therapy of melanoma. (C) 2000 Lippincott Williams and Wilkins.

    UR - http://www.scopus.com/inward/record.url?scp=0033818034&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0033818034&partnerID=8YFLogxK

    M3 - Article

    C2 - 10985664

    AN - SCOPUS:0033818034

    VL - 10

    SP - 303

    EP - 312

    JO - Melanoma Research

    JF - Melanoma Research

    SN - 0960-8931

    IS - 4

    ER -