Lichen amyloidosus

A study of clinical, histopathologic and immunofluorescence findings in 30 cases

T. Salim, S. D. Shenoi, C. Balachandran, Vandana R. Mehta

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Lichen amyloidosus (LA) is a primary localized cutaneous amyloidosis characterized clinically by discrete hyperkeratotic hyperpigmented papules and histologically by deposition of amyloid material in previously normal skin without any evidence of visceral involvement. Aims and objectives: The aim of this work was to study the etiology, clinical features, histopathology and direct immunofluorescence findings in LA. Methods: A prospective study of 30 patients with clinical, histological and immunofluorescence findings suggestive of LA was undertaken. After a detailed history and clinical examination, two punch biopsies for histopathology and immunofluorescence were taken. Results: Of the 30 patients, 19 (63.3%) were males and 11 (36.7%) were females with duration of LA ranging from 6-20 months. Pruritus was the presenting symptom in 27 (90%) patients. Shin was involved in 26 (86.7%) followed by arms in three (10%) and back in one (3.3%). Seventeen patients (56%) had used scrubs for more than 2 years. Histopathology, direct immunofluorescence and Congo red staining detected amyloid in all cases. Conclusions: LA commonly presents over the shins as pruritic discrete hyperpigmented papules. Familial predisposition and friction may have a pathogenic role. Histopathological examination is very useful in the detection of amyloid which may be supplemented with direct immunofluorescence and Congo red staining.

Original languageEnglish
Pages (from-to)166-169
Number of pages4
JournalIndian Journal of Dermatology, Venereology and Leprology
Volume71
Issue number3
Publication statusPublished - 01-05-2005

Fingerprint

Lichens
Fluorescent Antibody Technique
Direct Fluorescent Antibody Technique
Amyloid
Congo Red
Staining and Labeling
Friction
Pruritus
History
Clinical Studies
Prospective Studies
Biopsy
Skin

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

Cite this

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title = "Lichen amyloidosus: A study of clinical, histopathologic and immunofluorescence findings in 30 cases",
abstract = "Background: Lichen amyloidosus (LA) is a primary localized cutaneous amyloidosis characterized clinically by discrete hyperkeratotic hyperpigmented papules and histologically by deposition of amyloid material in previously normal skin without any evidence of visceral involvement. Aims and objectives: The aim of this work was to study the etiology, clinical features, histopathology and direct immunofluorescence findings in LA. Methods: A prospective study of 30 patients with clinical, histological and immunofluorescence findings suggestive of LA was undertaken. After a detailed history and clinical examination, two punch biopsies for histopathology and immunofluorescence were taken. Results: Of the 30 patients, 19 (63.3{\%}) were males and 11 (36.7{\%}) were females with duration of LA ranging from 6-20 months. Pruritus was the presenting symptom in 27 (90{\%}) patients. Shin was involved in 26 (86.7{\%}) followed by arms in three (10{\%}) and back in one (3.3{\%}). Seventeen patients (56{\%}) had used scrubs for more than 2 years. Histopathology, direct immunofluorescence and Congo red staining detected amyloid in all cases. Conclusions: LA commonly presents over the shins as pruritic discrete hyperpigmented papules. Familial predisposition and friction may have a pathogenic role. Histopathological examination is very useful in the detection of amyloid which may be supplemented with direct immunofluorescence and Congo red staining.",
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Lichen amyloidosus : A study of clinical, histopathologic and immunofluorescence findings in 30 cases. / Salim, T.; Shenoi, S. D.; Balachandran, C.; Mehta, Vandana R.

In: Indian Journal of Dermatology, Venereology and Leprology, Vol. 71, No. 3, 01.05.2005, p. 166-169.

Research output: Contribution to journalArticle

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T2 - A study of clinical, histopathologic and immunofluorescence findings in 30 cases

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