Lipid peroxidation inhibition and anti-anoxie property of 1-phenyl-3-(4-hydroxy-3, 5-ditertbutylphenyl), prop-2-en-1-one

D.V. Rajakumar, M.N.A. Rao

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A Phenyl Styryl ketone, with sterically hindered phenolic group, 1-phenyl-3-(4-hydroxy-3,5-ditertbutyiphenyl), prop-2-en-1-one (PHP) was evaluated as in vitro inhibitor of iron-ascorbate stimulated lipid peroxidation in rat brain homogenates. It was found to be more potent than the standard antioxidant vitamin E. Further PHP was evaluated for its effect in vivo against nitrogen-induced anoxia. The test compound protected the mice significantly against nitrogen-induced anoxia.
Original languageUndefined/Unknown
Pages (from-to)77-80
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume58
Issue number2
Publication statusPublished - 1996

Cite this

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title = "Lipid peroxidation inhibition and anti-anoxie property of 1-phenyl-3-(4-hydroxy-3, 5-ditertbutylphenyl), prop-2-en-1-one",
abstract = "A Phenyl Styryl ketone, with sterically hindered phenolic group, 1-phenyl-3-(4-hydroxy-3,5-ditertbutyiphenyl), prop-2-en-1-one (PHP) was evaluated as in vitro inhibitor of iron-ascorbate stimulated lipid peroxidation in rat brain homogenates. It was found to be more potent than the standard antioxidant vitamin E. Further PHP was evaluated for its effect in vivo against nitrogen-induced anoxia. The test compound protected the mice significantly against nitrogen-induced anoxia.",
author = "D.V. Rajakumar and M.N.A. Rao",
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volume = "58",
pages = "77--80",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
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Lipid peroxidation inhibition and anti-anoxie property of 1-phenyl-3-(4-hydroxy-3, 5-ditertbutylphenyl), prop-2-en-1-one. / Rajakumar, D.V.; Rao, M.N.A.

In: Indian Journal of Pharmaceutical Sciences, Vol. 58, No. 2, 1996, p. 77-80.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lipid peroxidation inhibition and anti-anoxie property of 1-phenyl-3-(4-hydroxy-3, 5-ditertbutylphenyl), prop-2-en-1-one

AU - Rajakumar, D.V.

AU - Rao, M.N.A.

N1 - cited By 3

PY - 1996

Y1 - 1996

N2 - A Phenyl Styryl ketone, with sterically hindered phenolic group, 1-phenyl-3-(4-hydroxy-3,5-ditertbutyiphenyl), prop-2-en-1-one (PHP) was evaluated as in vitro inhibitor of iron-ascorbate stimulated lipid peroxidation in rat brain homogenates. It was found to be more potent than the standard antioxidant vitamin E. Further PHP was evaluated for its effect in vivo against nitrogen-induced anoxia. The test compound protected the mice significantly against nitrogen-induced anoxia.

AB - A Phenyl Styryl ketone, with sterically hindered phenolic group, 1-phenyl-3-(4-hydroxy-3,5-ditertbutyiphenyl), prop-2-en-1-one (PHP) was evaluated as in vitro inhibitor of iron-ascorbate stimulated lipid peroxidation in rat brain homogenates. It was found to be more potent than the standard antioxidant vitamin E. Further PHP was evaluated for its effect in vivo against nitrogen-induced anoxia. The test compound protected the mice significantly against nitrogen-induced anoxia.

M3 - Article

VL - 58

SP - 77

EP - 80

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 2

ER -