Lipidomik ve bilişsel işlev bozukluğu – Bir Anlatı İncelemesi

Translated title of the contribution: Lipidomics and cognitive dysfunction – A Narrative review

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: More than half portion of the brain is formed by lipids. They play critical roles in maintaining the brain’s structural and functional components. Any dysregulation in these brain lipids can lead to cognitive dysfunction which are associated with neurological disorders such as Alzheimer’s disease, Parkinson’s disease, schizophrenia, vascular dementia etc. Studies have linked lipids with cognitive impairment. But not much has been studied about the complex brain lipids which might play a pivotal role in cognitive impairment. This review aims to highlight the lipidomic profiles in patients with cognitive dysfunction. Results: Forty-five articles were reviewed. These studies show alterations in complex lipids such as sphingolipids, phospholipids, glycolipids and sterols in brain in various neurological disorders such as vascular dementia, Parkinson’s and Alzheimer’s disease. However, the classes of fatty acids in these lipids involved are different across studies. Conclusions: There is a need for targeted lipidomics analysis, specifically including sphingolipids in patients with neurodegenerative disorders so as to improve diagnostics as well as management of these disorders.

Translated title of the contributionLipidomics and cognitive dysfunction – A Narrative review
Original languageTurkish
Article number20200134
JournalTurkish Journal of Biochemistry
Volume45
Issue number2
DOIs
Publication statusPublished - 04-2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry, medical

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