Localized in situ nanoemulgel drug delivery system of quercetin for periodontitis

Development and computational simulations

Gururaj C. Aithal, Usha Yogendra Nayak, Chetan Mehta, Reema Narayan, Pratibha Gopalkrishna, Sudharsan Pandiyan, Sanjay Garg

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study was aimed at formulating a bioabsorbable, controlled-release, nanoemulgel of Quercetin, a potent antimicrobial and anti-inflammatory agent for the treatment of periodontitis that could improve its solubility and bioavailability. Screening of components was carried out based on the solubility studies. Nanoemulsion containing cinnamon oil as the oil phase, tween 80 and Carbitolfi as the surfactant-cosurfactant mixture (Smix) and water as the aqueous phase containing 125 µg/200 µL of Quercetin was prepared by using spontaneous emulsification method. Nanoemulgel was prepared using 23% w/v poloxamer 407 as gel base. Comprehensive evaluation of the formulated nanoemulgel was carried out, and the optimized formulation was studied for drug release using Franz vertical diffusion cells. The formulated nanoemulgelexhibited a remarkable release of 92.4% of Quercetin at the end of 6 h, as compared to that of pure Quercetin-loaded gel (<3% release). The viscosity of the prepared nanoemulgel was found to be 30,647 ± 0.32 cPs at 37C. Also, molecular dynamics (MD) simulation was utilized to understand the gelation process and role of each component in the formulation. The present study revealed that the developed nanoemulgel of Quercetin could be a potential delivery system for clinical testing in periodontitis.

Original languageEnglish
Article number1363
JournalMolecules
Volume23
Issue number6
DOIs
Publication statusPublished - 01-01-2018

Fingerprint

Periodontitis
Quercetin
Drug Delivery Systems
delivery
drugs
solubility
oils
gels
formulations
bioavailability
gelation
screening
simulation
Solubility
surfactants
viscosity
molecular dynamics
Oils
Gels
evaluation

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Aithal, Gururaj C. ; Nayak, Usha Yogendra ; Mehta, Chetan ; Narayan, Reema ; Gopalkrishna, Pratibha ; Pandiyan, Sudharsan ; Garg, Sanjay. / Localized in situ nanoemulgel drug delivery system of quercetin for periodontitis : Development and computational simulations. In: Molecules. 2018 ; Vol. 23, No. 6.
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Localized in situ nanoemulgel drug delivery system of quercetin for periodontitis : Development and computational simulations. / Aithal, Gururaj C.; Nayak, Usha Yogendra; Mehta, Chetan; Narayan, Reema; Gopalkrishna, Pratibha; Pandiyan, Sudharsan; Garg, Sanjay.

In: Molecules, Vol. 23, No. 6, 1363, 01.01.2018.

Research output: Contribution to journalArticle

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