Long-term Chikungunya Sequelae in Curaçao

Burden, determinants, and a novel classification tool

Jelte Elsinga, Izzy Gerstenbluth, Symkje Van Der Ploeg, Yaskara Halabi, Norédiz T. Lourents, Johannes G. Burgerhof, Henry T. Van Der Veen, Ajay Bailey, Martin P. Grobusch, Adriana Tami

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Beyond the acute illness phase, chikungunya constitutes a public health problem given its chronic disease phase, which may include long-term arthralgia, arthritis, fatigue, and depression. Currently, there is no consensus on how to define chikungunya chronicity. Methods: A comprehensive cross-sectional survey was performed in Curaçao in June and July 2015 to evaluate 304 adult laboratory-confirmed chikungunya patients 3-16 months after diagnosis. We developed a novel tool, the Curaçao Long-Term Chikungunya Sequelae (CLTCS) score, to classify chronic chikungunya disease and estimate its burden regarding disease duration, clinical presentation, and impact on quality of life. Results: Disease persistence was estimated to be 79% one month after symptom onset and 64% after 400 days. Chikungunya persistence was characterized by higher proportions of arthralgia, weakness, myalgia, and age 41-60 years. Individuals were classified as "highly affected," "mildly affected," and "recovered." "Highly affected" disease status was associated with clinical complaints (arthralgia, weakness, loss of vitality, and being diabetic) and major decreases in quality-of-life scores. Conclusions: In the Caribbean, a high proportion of chikungunya patients remains chronically affected. We propose the CLTCS as a suitable score to easily and rapidly classify the severity of chikungunya chronic disease and to assess the need for symptom-alleviating treatment.

Original languageEnglish
Pages (from-to)573-581
Number of pages9
JournalJournal of Infectious Diseases
Volume216
Issue number5
DOIs
Publication statusPublished - 01-09-2017

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Arthralgia
Chronic Disease
Quality of Life
Myalgia
Arthritis
Fatigue
Consensus
Public Health
Cross-Sectional Studies
Depression
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Elsinga, J., Gerstenbluth, I., Van Der Ploeg, S., Halabi, Y., Lourents, N. T., Burgerhof, J. G., ... Tami, A. (2017). Long-term Chikungunya Sequelae in Curaçao: Burden, determinants, and a novel classification tool. Journal of Infectious Diseases, 216(5), 573-581. https://doi.org/10.1093/infdis/jix312
Elsinga, Jelte ; Gerstenbluth, Izzy ; Van Der Ploeg, Symkje ; Halabi, Yaskara ; Lourents, Norédiz T. ; Burgerhof, Johannes G. ; Van Der Veen, Henry T. ; Bailey, Ajay ; Grobusch, Martin P. ; Tami, Adriana. / Long-term Chikungunya Sequelae in Curaçao : Burden, determinants, and a novel classification tool. In: Journal of Infectious Diseases. 2017 ; Vol. 216, No. 5. pp. 573-581.
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Elsinga, J, Gerstenbluth, I, Van Der Ploeg, S, Halabi, Y, Lourents, NT, Burgerhof, JG, Van Der Veen, HT, Bailey, A, Grobusch, MP & Tami, A 2017, 'Long-term Chikungunya Sequelae in Curaçao: Burden, determinants, and a novel classification tool', Journal of Infectious Diseases, vol. 216, no. 5, pp. 573-581. https://doi.org/10.1093/infdis/jix312

Long-term Chikungunya Sequelae in Curaçao : Burden, determinants, and a novel classification tool. / Elsinga, Jelte; Gerstenbluth, Izzy; Van Der Ploeg, Symkje; Halabi, Yaskara; Lourents, Norédiz T.; Burgerhof, Johannes G.; Van Der Veen, Henry T.; Bailey, Ajay; Grobusch, Martin P.; Tami, Adriana.

In: Journal of Infectious Diseases, Vol. 216, No. 5, 01.09.2017, p. 573-581.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Long-term Chikungunya Sequelae in Curaçao

T2 - Burden, determinants, and a novel classification tool

AU - Elsinga, Jelte

AU - Gerstenbluth, Izzy

AU - Van Der Ploeg, Symkje

AU - Halabi, Yaskara

AU - Lourents, Norédiz T.

AU - Burgerhof, Johannes G.

AU - Van Der Veen, Henry T.

AU - Bailey, Ajay

AU - Grobusch, Martin P.

AU - Tami, Adriana

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background: Beyond the acute illness phase, chikungunya constitutes a public health problem given its chronic disease phase, which may include long-term arthralgia, arthritis, fatigue, and depression. Currently, there is no consensus on how to define chikungunya chronicity. Methods: A comprehensive cross-sectional survey was performed in Curaçao in June and July 2015 to evaluate 304 adult laboratory-confirmed chikungunya patients 3-16 months after diagnosis. We developed a novel tool, the Curaçao Long-Term Chikungunya Sequelae (CLTCS) score, to classify chronic chikungunya disease and estimate its burden regarding disease duration, clinical presentation, and impact on quality of life. Results: Disease persistence was estimated to be 79% one month after symptom onset and 64% after 400 days. Chikungunya persistence was characterized by higher proportions of arthralgia, weakness, myalgia, and age 41-60 years. Individuals were classified as "highly affected," "mildly affected," and "recovered." "Highly affected" disease status was associated with clinical complaints (arthralgia, weakness, loss of vitality, and being diabetic) and major decreases in quality-of-life scores. Conclusions: In the Caribbean, a high proportion of chikungunya patients remains chronically affected. We propose the CLTCS as a suitable score to easily and rapidly classify the severity of chikungunya chronic disease and to assess the need for symptom-alleviating treatment.

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Elsinga J, Gerstenbluth I, Van Der Ploeg S, Halabi Y, Lourents NT, Burgerhof JG et al. Long-term Chikungunya Sequelae in Curaçao: Burden, determinants, and a novel classification tool. Journal of Infectious Diseases. 2017 Sep 1;216(5):573-581. https://doi.org/10.1093/infdis/jix312