Long-term effects of diagnostic ultrasound during fetal period on postnatal development and adult behavior of mouse

R. Suresh, P. Uma Devi, N. Ovchinnikov, A. McRae

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Pregnant Swiss albino mice were exposed to diagnostic levels of ultrasound (3.5 MHz, intensity 65 mW, ISPTP = 1 W/cm2, ISATA = 240 W/cm2) for 10, 20 and 30 minutes on day 14 of gestation. Sham exposed controls were maintained for comparison. Fifteen pregnant mice were exposed for each group. Exposed as well as control animals were left to complete gestation and parturition. Ultrasound induced changes in maternal vaginal temperature was recorded. The changes in the physiological reflexes and postnatal mortality up to 6 weeks of age were recorded. The litters were subjected to behavioral tests for locomotor activity, learning and memory at 4 month and 1 year of age. Neither the physiological reflexes nor the postnatal mortality was affected by ultrasound exposure. However, there was a noticeable impairment in both locomotor and learning behavior even after a 10 min exposure, which further increased with increases in exposure time. Thus the present study demonstrates the neurotoxicity of diagnostic ultrasound and the high susceptibility of early fetal brain to induction of lasting detrimental changes by ultrasound exposure.

Original languageEnglish
Pages (from-to)339-350
Number of pages12
JournalLife Sciences
Volume71
Issue number3
DOIs
Publication statusPublished - 07-06-2002
Externally publishedYes

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Reflex
Ultrasonography
Ultrasonics
Learning
Pregnancy
Mortality
Locomotion
Mothers
Parturition
Temperature
Brain
Animals
Data storage equipment
Behavior Rating Scale

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Suresh, R. ; Uma Devi, P. ; Ovchinnikov, N. ; McRae, A. / Long-term effects of diagnostic ultrasound during fetal period on postnatal development and adult behavior of mouse. In: Life Sciences. 2002 ; Vol. 71, No. 3. pp. 339-350.
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Long-term effects of diagnostic ultrasound during fetal period on postnatal development and adult behavior of mouse. / Suresh, R.; Uma Devi, P.; Ovchinnikov, N.; McRae, A.

In: Life Sciences, Vol. 71, No. 3, 07.06.2002, p. 339-350.

Research output: Contribution to journalArticle

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