Low-dose methotrexate as a steroid-sparing agent in a child with Takayasu's arteritis

A. K. Shetty, A. R. Stopa, A. Gedalia

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Takayasu's arteritis (TA) is a chronic inflammatory arteriopathy affecting the large vessels and has been described predominantly in young adult women. In children it presents as an aggressive disease usually requiring chronic corticosteroid therapy. At present, low dose oral methotrexate (MTX) appears to be an effective steroid-sparing agent in adult patients with active TA. We report a 4-year-old child with Takayasu's arteritis who was initially placed on oral prednisone (2 mg/kg/day) therapy. Three months later, low-dose oral MTX (10 mg/m2/week) was added. Prednisone was successfully tapered over the following year to 0.2 mg/kg every other day. A repeat angiography following 12 months of therapy revealed a dramatic improvement of the vascular lesions. No toxicity was observed with MTX therapy. In conclusion, low-dose oral MTX appeared to be an efficient, safe and steroid-sparing agent in the treatment of a young child with TA.

Original languageEnglish
Pages (from-to)335-336
Number of pages2
JournalClinical and Experimental Rheumatology
Volume16
Issue number3
Publication statusPublished - 25-05-1998
Externally publishedYes

Fingerprint

Takayasu Arteritis
Methotrexate
Steroids
Prednisone
Therapeutics
Blood Vessels
Young Adult
Angiography
Adrenal Cortex Hormones

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

Shetty, A. K. ; Stopa, A. R. ; Gedalia, A. / Low-dose methotrexate as a steroid-sparing agent in a child with Takayasu's arteritis. In: Clinical and Experimental Rheumatology. 1998 ; Vol. 16, No. 3. pp. 335-336.
@article{5153dfd81c9b475f9abf467731e7afb5,
title = "Low-dose methotrexate as a steroid-sparing agent in a child with Takayasu's arteritis",
abstract = "Takayasu's arteritis (TA) is a chronic inflammatory arteriopathy affecting the large vessels and has been described predominantly in young adult women. In children it presents as an aggressive disease usually requiring chronic corticosteroid therapy. At present, low dose oral methotrexate (MTX) appears to be an effective steroid-sparing agent in adult patients with active TA. We report a 4-year-old child with Takayasu's arteritis who was initially placed on oral prednisone (2 mg/kg/day) therapy. Three months later, low-dose oral MTX (10 mg/m2/week) was added. Prednisone was successfully tapered over the following year to 0.2 mg/kg every other day. A repeat angiography following 12 months of therapy revealed a dramatic improvement of the vascular lesions. No toxicity was observed with MTX therapy. In conclusion, low-dose oral MTX appeared to be an efficient, safe and steroid-sparing agent in the treatment of a young child with TA.",
author = "Shetty, {A. K.} and Stopa, {A. R.} and A. Gedalia",
year = "1998",
month = "5",
day = "25",
language = "English",
volume = "16",
pages = "335--336",
journal = "Clinical and Experimental Rheumatology",
issn = "0392-856X",
publisher = "Clinical and Experimental Rheumatology S.A.S.",
number = "3",

}

Low-dose methotrexate as a steroid-sparing agent in a child with Takayasu's arteritis. / Shetty, A. K.; Stopa, A. R.; Gedalia, A.

In: Clinical and Experimental Rheumatology, Vol. 16, No. 3, 25.05.1998, p. 335-336.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low-dose methotrexate as a steroid-sparing agent in a child with Takayasu's arteritis

AU - Shetty, A. K.

AU - Stopa, A. R.

AU - Gedalia, A.

PY - 1998/5/25

Y1 - 1998/5/25

N2 - Takayasu's arteritis (TA) is a chronic inflammatory arteriopathy affecting the large vessels and has been described predominantly in young adult women. In children it presents as an aggressive disease usually requiring chronic corticosteroid therapy. At present, low dose oral methotrexate (MTX) appears to be an effective steroid-sparing agent in adult patients with active TA. We report a 4-year-old child with Takayasu's arteritis who was initially placed on oral prednisone (2 mg/kg/day) therapy. Three months later, low-dose oral MTX (10 mg/m2/week) was added. Prednisone was successfully tapered over the following year to 0.2 mg/kg every other day. A repeat angiography following 12 months of therapy revealed a dramatic improvement of the vascular lesions. No toxicity was observed with MTX therapy. In conclusion, low-dose oral MTX appeared to be an efficient, safe and steroid-sparing agent in the treatment of a young child with TA.

AB - Takayasu's arteritis (TA) is a chronic inflammatory arteriopathy affecting the large vessels and has been described predominantly in young adult women. In children it presents as an aggressive disease usually requiring chronic corticosteroid therapy. At present, low dose oral methotrexate (MTX) appears to be an effective steroid-sparing agent in adult patients with active TA. We report a 4-year-old child with Takayasu's arteritis who was initially placed on oral prednisone (2 mg/kg/day) therapy. Three months later, low-dose oral MTX (10 mg/m2/week) was added. Prednisone was successfully tapered over the following year to 0.2 mg/kg every other day. A repeat angiography following 12 months of therapy revealed a dramatic improvement of the vascular lesions. No toxicity was observed with MTX therapy. In conclusion, low-dose oral MTX appeared to be an efficient, safe and steroid-sparing agent in the treatment of a young child with TA.

UR - http://www.scopus.com/inward/record.url?scp=0031981921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031981921&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 335

EP - 336

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

IS - 3

ER -