Abstract

Low Grade Central Osteosarcoma (LGCO) is a rare intramedullary and well differentiated variant of osteosarcoma with a better prognosis than the more common conventional variant. It was first described by Unni et al., in 1977. Due to its subtle histological features of malignancy, it is difficult to diagnose on biopsy. Even in the resection specimen it can be mistaken for lesions like fibrous dysplasia, desmoplastic fibroma, parosteal osteosarcoma and fibrosarcoma. Adequate sampling of the tumour is essential to arrive at a correct diagnosis. Histological features such as cytological atypia, mitotic activity, permeation into the bone marrow, entrapment of the native bone, cortical disruption and soft tissue extension will help in the diagnosis of this tumour. We report a case of a 30-year-old man who presented with pain in the right hip of three months duration. On radiological evaluation, a lytic lesion was noted in the upper part of right femur and a possible diagnosis of locally aggressive giant cell tumour of bone was proposed. On histopathological study of the resected upper part of the right femur, a diagnosis of LGCO was rendered.

Original languageEnglish
Pages (from-to)ED06-ED08
JournalJournal of Clinical and Diagnostic Research
Volume12
Issue number7
DOIs
Publication statusPublished - 01-07-2018

Fingerprint

Osteosarcoma
Tumors
Bone
Femur
Desmoplastic Fibroma
Giant Cell Tumor of Bone
Neoplasms
Biopsy
Fibrosarcoma
Permeation
Hip
Bone Marrow
Tissue
Sampling
Pain

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

@article{e3a1f841a3f84469905d496e0ad5c27b,
title = "Low grade central osteosarcoma-a diagnostic challenge",
abstract = "Low Grade Central Osteosarcoma (LGCO) is a rare intramedullary and well differentiated variant of osteosarcoma with a better prognosis than the more common conventional variant. It was first described by Unni et al., in 1977. Due to its subtle histological features of malignancy, it is difficult to diagnose on biopsy. Even in the resection specimen it can be mistaken for lesions like fibrous dysplasia, desmoplastic fibroma, parosteal osteosarcoma and fibrosarcoma. Adequate sampling of the tumour is essential to arrive at a correct diagnosis. Histological features such as cytological atypia, mitotic activity, permeation into the bone marrow, entrapment of the native bone, cortical disruption and soft tissue extension will help in the diagnosis of this tumour. We report a case of a 30-year-old man who presented with pain in the right hip of three months duration. On radiological evaluation, a lytic lesion was noted in the upper part of right femur and a possible diagnosis of locally aggressive giant cell tumour of bone was proposed. On histopathological study of the resected upper part of the right femur, a diagnosis of LGCO was rendered.",
author = "Srilatha, {Parampalli Srinivas} and Ranjini Kudva and Mohanty, {Simanchal P.}",
year = "2018",
month = "7",
day = "1",
doi = "10.7860/JCDR/2018/35819.11822",
language = "English",
volume = "12",
pages = "ED06--ED08",
journal = "Journal of Clinical and Diagnostic Research",
issn = "2249-782X",
publisher = "Journal of Clinical and Diagnostic Research",
number = "7",

}

Low grade central osteosarcoma-a diagnostic challenge. / Srilatha, Parampalli Srinivas; Kudva, Ranjini; Mohanty, Simanchal P.

In: Journal of Clinical and Diagnostic Research, Vol. 12, No. 7, 01.07.2018, p. ED06-ED08.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low grade central osteosarcoma-a diagnostic challenge

AU - Srilatha, Parampalli Srinivas

AU - Kudva, Ranjini

AU - Mohanty, Simanchal P.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Low Grade Central Osteosarcoma (LGCO) is a rare intramedullary and well differentiated variant of osteosarcoma with a better prognosis than the more common conventional variant. It was first described by Unni et al., in 1977. Due to its subtle histological features of malignancy, it is difficult to diagnose on biopsy. Even in the resection specimen it can be mistaken for lesions like fibrous dysplasia, desmoplastic fibroma, parosteal osteosarcoma and fibrosarcoma. Adequate sampling of the tumour is essential to arrive at a correct diagnosis. Histological features such as cytological atypia, mitotic activity, permeation into the bone marrow, entrapment of the native bone, cortical disruption and soft tissue extension will help in the diagnosis of this tumour. We report a case of a 30-year-old man who presented with pain in the right hip of three months duration. On radiological evaluation, a lytic lesion was noted in the upper part of right femur and a possible diagnosis of locally aggressive giant cell tumour of bone was proposed. On histopathological study of the resected upper part of the right femur, a diagnosis of LGCO was rendered.

AB - Low Grade Central Osteosarcoma (LGCO) is a rare intramedullary and well differentiated variant of osteosarcoma with a better prognosis than the more common conventional variant. It was first described by Unni et al., in 1977. Due to its subtle histological features of malignancy, it is difficult to diagnose on biopsy. Even in the resection specimen it can be mistaken for lesions like fibrous dysplasia, desmoplastic fibroma, parosteal osteosarcoma and fibrosarcoma. Adequate sampling of the tumour is essential to arrive at a correct diagnosis. Histological features such as cytological atypia, mitotic activity, permeation into the bone marrow, entrapment of the native bone, cortical disruption and soft tissue extension will help in the diagnosis of this tumour. We report a case of a 30-year-old man who presented with pain in the right hip of three months duration. On radiological evaluation, a lytic lesion was noted in the upper part of right femur and a possible diagnosis of locally aggressive giant cell tumour of bone was proposed. On histopathological study of the resected upper part of the right femur, a diagnosis of LGCO was rendered.

UR - http://www.scopus.com/inward/record.url?scp=85049431777&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049431777&partnerID=8YFLogxK

U2 - 10.7860/JCDR/2018/35819.11822

DO - 10.7860/JCDR/2018/35819.11822

M3 - Article

AN - SCOPUS:85049431777

VL - 12

SP - ED06-ED08

JO - Journal of Clinical and Diagnostic Research

JF - Journal of Clinical and Diagnostic Research

SN - 2249-782X

IS - 7

ER -