Low level helium neon laser therapy for chemoradiotherapy induced oral mucositis in oral cancer patients - A randomized controlled trial

Ajay Prashad Gautam, Donald J. Fernandes, Mamidipudi S. Vidyasagar, G. Arun Maiya

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Patients receiving chemoradiotherapy (CRT) for oral cancer (OC) often develop oral mucositis (OM). OM associated pain severely affects oral functions and nutrition of the patient, resulting in narcotic analgesic use and CRT interruption. Laser therapy has shown some promising results in preventing and treating OM caused by cancer therapies. So in this trial we used prophylactic Low Level Helium Neon (He-Ne) Laser for the prevention and treatment of CRT induced OM in OC patients. Materials and methods: This double blinded trial block randomized 121primary OC patients scheduled to undergo CRT [RT dosage = 66Gray/33fractions for 5 days/week and chemotherapy (3 weekly Cisplatin)] into laser (n = 60) and placebo (n = 61) group. Laser group received He-Ne Laser (λ = 632.8 nm, P = 24 mW, ED = 3.5 J/cm2) while placebo received sham treatment just before radiation for 6.5 weeks. OM (RTOG/EORTC Scale), its associated pain, and total parenteral nutrition (TPN), were assessed on every week by a blinded assessor. Also opioid analgesic use, weight loss and any CRT break were recorded. Data was analyzed using descriptive statistics, t-test and Man Whitney U test. Level of significance was set at p < 0.05. Results: Incidence of severe OM (29% vs. 89%, p < 0.001) and its associated pain (18% vs. 71%, p < 0.001), opioid analgesic use (7% vs. 21%, p < 0.001)and TPN (30% vs. 39% p = 0.039) was significantly less in laser than placebo group patients. Also duration of severe OM and pain experienced was less in laser than placebo group. CRT break required only for placebo group (9%) patients. Conclusion: Low Level He-Ne Laser decreased the incidence of CRT induced severe OM and its associated pain, opioid analgesics use and TPN.

Original languageEnglish
Pages (from-to)893-897
Number of pages5
JournalOral Oncology
Volume48
Issue number9
DOIs
Publication statusPublished - 01-09-2012

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Neon
Stomatitis
Gas Lasers
Mouth Neoplasms
Laser Therapy
Chemoradiotherapy
Randomized Controlled Trials
Placebos
Total Parenteral Nutrition
Lasers
Pain
Opioid Analgesics
Narcotics
Incidence
Cisplatin
Weight Loss
Radiation
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

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title = "Low level helium neon laser therapy for chemoradiotherapy induced oral mucositis in oral cancer patients - A randomized controlled trial",
abstract = "Background: Patients receiving chemoradiotherapy (CRT) for oral cancer (OC) often develop oral mucositis (OM). OM associated pain severely affects oral functions and nutrition of the patient, resulting in narcotic analgesic use and CRT interruption. Laser therapy has shown some promising results in preventing and treating OM caused by cancer therapies. So in this trial we used prophylactic Low Level Helium Neon (He-Ne) Laser for the prevention and treatment of CRT induced OM in OC patients. Materials and methods: This double blinded trial block randomized 121primary OC patients scheduled to undergo CRT [RT dosage = 66Gray/33fractions for 5 days/week and chemotherapy (3 weekly Cisplatin)] into laser (n = 60) and placebo (n = 61) group. Laser group received He-Ne Laser (λ = 632.8 nm, P = 24 mW, ED = 3.5 J/cm2) while placebo received sham treatment just before radiation for 6.5 weeks. OM (RTOG/EORTC Scale), its associated pain, and total parenteral nutrition (TPN), were assessed on every week by a blinded assessor. Also opioid analgesic use, weight loss and any CRT break were recorded. Data was analyzed using descriptive statistics, t-test and Man Whitney U test. Level of significance was set at p < 0.05. Results: Incidence of severe OM (29{\%} vs. 89{\%}, p < 0.001) and its associated pain (18{\%} vs. 71{\%}, p < 0.001), opioid analgesic use (7{\%} vs. 21{\%}, p < 0.001)and TPN (30{\%} vs. 39{\%} p = 0.039) was significantly less in laser than placebo group patients. Also duration of severe OM and pain experienced was less in laser than placebo group. CRT break required only for placebo group (9{\%}) patients. Conclusion: Low Level He-Ne Laser decreased the incidence of CRT induced severe OM and its associated pain, opioid analgesics use and TPN.",
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Low level helium neon laser therapy for chemoradiotherapy induced oral mucositis in oral cancer patients - A randomized controlled trial. / Gautam, Ajay Prashad; Fernandes, Donald J.; Vidyasagar, Mamidipudi S.; Maiya, G. Arun.

In: Oral Oncology, Vol. 48, No. 9, 01.09.2012, p. 893-897.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low level helium neon laser therapy for chemoradiotherapy induced oral mucositis in oral cancer patients - A randomized controlled trial

AU - Gautam, Ajay Prashad

AU - Fernandes, Donald J.

AU - Vidyasagar, Mamidipudi S.

AU - Maiya, G. Arun

PY - 2012/9/1

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N2 - Background: Patients receiving chemoradiotherapy (CRT) for oral cancer (OC) often develop oral mucositis (OM). OM associated pain severely affects oral functions and nutrition of the patient, resulting in narcotic analgesic use and CRT interruption. Laser therapy has shown some promising results in preventing and treating OM caused by cancer therapies. So in this trial we used prophylactic Low Level Helium Neon (He-Ne) Laser for the prevention and treatment of CRT induced OM in OC patients. Materials and methods: This double blinded trial block randomized 121primary OC patients scheduled to undergo CRT [RT dosage = 66Gray/33fractions for 5 days/week and chemotherapy (3 weekly Cisplatin)] into laser (n = 60) and placebo (n = 61) group. Laser group received He-Ne Laser (λ = 632.8 nm, P = 24 mW, ED = 3.5 J/cm2) while placebo received sham treatment just before radiation for 6.5 weeks. OM (RTOG/EORTC Scale), its associated pain, and total parenteral nutrition (TPN), were assessed on every week by a blinded assessor. Also opioid analgesic use, weight loss and any CRT break were recorded. Data was analyzed using descriptive statistics, t-test and Man Whitney U test. Level of significance was set at p < 0.05. Results: Incidence of severe OM (29% vs. 89%, p < 0.001) and its associated pain (18% vs. 71%, p < 0.001), opioid analgesic use (7% vs. 21%, p < 0.001)and TPN (30% vs. 39% p = 0.039) was significantly less in laser than placebo group patients. Also duration of severe OM and pain experienced was less in laser than placebo group. CRT break required only for placebo group (9%) patients. Conclusion: Low Level He-Ne Laser decreased the incidence of CRT induced severe OM and its associated pain, opioid analgesics use and TPN.

AB - Background: Patients receiving chemoradiotherapy (CRT) for oral cancer (OC) often develop oral mucositis (OM). OM associated pain severely affects oral functions and nutrition of the patient, resulting in narcotic analgesic use and CRT interruption. Laser therapy has shown some promising results in preventing and treating OM caused by cancer therapies. So in this trial we used prophylactic Low Level Helium Neon (He-Ne) Laser for the prevention and treatment of CRT induced OM in OC patients. Materials and methods: This double blinded trial block randomized 121primary OC patients scheduled to undergo CRT [RT dosage = 66Gray/33fractions for 5 days/week and chemotherapy (3 weekly Cisplatin)] into laser (n = 60) and placebo (n = 61) group. Laser group received He-Ne Laser (λ = 632.8 nm, P = 24 mW, ED = 3.5 J/cm2) while placebo received sham treatment just before radiation for 6.5 weeks. OM (RTOG/EORTC Scale), its associated pain, and total parenteral nutrition (TPN), were assessed on every week by a blinded assessor. Also opioid analgesic use, weight loss and any CRT break were recorded. Data was analyzed using descriptive statistics, t-test and Man Whitney U test. Level of significance was set at p < 0.05. Results: Incidence of severe OM (29% vs. 89%, p < 0.001) and its associated pain (18% vs. 71%, p < 0.001), opioid analgesic use (7% vs. 21%, p < 0.001)and TPN (30% vs. 39% p = 0.039) was significantly less in laser than placebo group patients. Also duration of severe OM and pain experienced was less in laser than placebo group. CRT break required only for placebo group (9%) patients. Conclusion: Low Level He-Ne Laser decreased the incidence of CRT induced severe OM and its associated pain, opioid analgesics use and TPN.

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