Abstract

Background Maternal lower genital tract during pregnancy is a complex niche of microbes that normally inhabit or cause infections in few instances. Association of various microbial flora and adverse pregnancy outcomes is being increasingly explored. The study was aimed to determine the prevalence of lower genital tract infections (LGTI)among pregnant women and to determine the common etiologies of LGTI and their association with adverse pregnancy outcomes, Pre term birth (PTB) and Low birth weight (LBW). Methods A hospital based observational cohort study comprising 486 asymptomatic, antenatal women in the age group of 18-35 and the gestational period of 8-24 weeks was carried out. High vaginal and endocervical swabs were tested for Nugent's score, culture and PCR for Mycoplasmas and Chlamydia. All the women were followed until delivery. Results Prevalence of LGTI s among study population was 134(28%) comprising BV (2%), candidiasis (13%) , trichomoniasis(8%) and anaerobic vaginitis (9%). Nugent's scoring delineated study subjects as Grade I (84%), Grade II (14%) and Grade III (2%). Prevalence of various microbes were; G.vaginalis (2%), Candida sp (16%), anaerobic GNB (12%),anaerobic GPB (9%) and Mycoplasmas (8%). Prevalence of PTB and LBW were; 30(6%) and 59(13%) respectively. Presence of anaerobic GNB and GPB (Nugent's Grade II organisms) was statistically significant with both PTB(p = >0.01, 0.005) and LBW (p = 0.001, 0.026). Conclusion Incorporation of a simple diagnostic modality like Nugent's scoring system in antenatal care can help inearly diagnosis and management of asymptomatic LGTIs; thereby reduce associated adverse pregnancy outcomes.

Original languageEnglish
Article numberE35
JournalBMC Infectious Diseases
Volume14
DOIs
Publication statusPublished - 2014

Fingerprint

Reproductive Tract Infections
Pregnancy Outcome
Term Birth
Observational Studies
Low Birth Weight Infant
Cohort Studies
Mycoplasma
Vaginitis
Prenatal Care
Chlamydia
Candidiasis
Candida
Pregnant Women
Age Groups
Mothers
Pregnancy
Polymerase Chain Reaction
Infection
Population

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

Cite this

@article{aba2e51ffeb24f6499c9fcad3596f048,
title = "Lower genital tract infections during pregnancyand adverse pregnancy outcomes: A hospitalbased observational cohort study",
abstract = "Background Maternal lower genital tract during pregnancy is a complex niche of microbes that normally inhabit or cause infections in few instances. Association of various microbial flora and adverse pregnancy outcomes is being increasingly explored. The study was aimed to determine the prevalence of lower genital tract infections (LGTI)among pregnant women and to determine the common etiologies of LGTI and their association with adverse pregnancy outcomes, Pre term birth (PTB) and Low birth weight (LBW). Methods A hospital based observational cohort study comprising 486 asymptomatic, antenatal women in the age group of 18-35 and the gestational period of 8-24 weeks was carried out. High vaginal and endocervical swabs were tested for Nugent's score, culture and PCR for Mycoplasmas and Chlamydia. All the women were followed until delivery. Results Prevalence of LGTI s among study population was 134(28{\%}) comprising BV (2{\%}), candidiasis (13{\%}) , trichomoniasis(8{\%}) and anaerobic vaginitis (9{\%}). Nugent's scoring delineated study subjects as Grade I (84{\%}), Grade II (14{\%}) and Grade III (2{\%}). Prevalence of various microbes were; G.vaginalis (2{\%}), Candida sp (16{\%}), anaerobic GNB (12{\%}),anaerobic GPB (9{\%}) and Mycoplasmas (8{\%}). Prevalence of PTB and LBW were; 30(6{\%}) and 59(13{\%}) respectively. Presence of anaerobic GNB and GPB (Nugent's Grade II organisms) was statistically significant with both PTB(p = >0.01, 0.005) and LBW (p = 0.001, 0.026). Conclusion Incorporation of a simple diagnostic modality like Nugent's scoring system in antenatal care can help inearly diagnosis and management of asymptomatic LGTIs; thereby reduce associated adverse pregnancy outcomes.",
author = "Chaitanya Tellapragada and Vandana, {K. E.} and Bhat, {Parvati V.} and Chythra Rao and Asha Kamath and Satheesha Nayak and V. Shashidhar and Shashidhar Acharya and Chiranjay Mukhopadhyay",
year = "2014",
doi = "10.1186/1471-2334-14-S3-E35",
language = "English",
volume = "14",
journal = "BMC Infectious Diseases",
issn = "1471-2334",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Lower genital tract infections during pregnancyand adverse pregnancy outcomes

T2 - A hospitalbased observational cohort study

AU - Tellapragada, Chaitanya

AU - Vandana, K. E.

AU - Bhat, Parvati V.

AU - Rao, Chythra

AU - Kamath, Asha

AU - Nayak, Satheesha

AU - Shashidhar, V.

AU - Acharya, Shashidhar

AU - Mukhopadhyay, Chiranjay

PY - 2014

Y1 - 2014

N2 - Background Maternal lower genital tract during pregnancy is a complex niche of microbes that normally inhabit or cause infections in few instances. Association of various microbial flora and adverse pregnancy outcomes is being increasingly explored. The study was aimed to determine the prevalence of lower genital tract infections (LGTI)among pregnant women and to determine the common etiologies of LGTI and their association with adverse pregnancy outcomes, Pre term birth (PTB) and Low birth weight (LBW). Methods A hospital based observational cohort study comprising 486 asymptomatic, antenatal women in the age group of 18-35 and the gestational period of 8-24 weeks was carried out. High vaginal and endocervical swabs were tested for Nugent's score, culture and PCR for Mycoplasmas and Chlamydia. All the women were followed until delivery. Results Prevalence of LGTI s among study population was 134(28%) comprising BV (2%), candidiasis (13%) , trichomoniasis(8%) and anaerobic vaginitis (9%). Nugent's scoring delineated study subjects as Grade I (84%), Grade II (14%) and Grade III (2%). Prevalence of various microbes were; G.vaginalis (2%), Candida sp (16%), anaerobic GNB (12%),anaerobic GPB (9%) and Mycoplasmas (8%). Prevalence of PTB and LBW were; 30(6%) and 59(13%) respectively. Presence of anaerobic GNB and GPB (Nugent's Grade II organisms) was statistically significant with both PTB(p = >0.01, 0.005) and LBW (p = 0.001, 0.026). Conclusion Incorporation of a simple diagnostic modality like Nugent's scoring system in antenatal care can help inearly diagnosis and management of asymptomatic LGTIs; thereby reduce associated adverse pregnancy outcomes.

AB - Background Maternal lower genital tract during pregnancy is a complex niche of microbes that normally inhabit or cause infections in few instances. Association of various microbial flora and adverse pregnancy outcomes is being increasingly explored. The study was aimed to determine the prevalence of lower genital tract infections (LGTI)among pregnant women and to determine the common etiologies of LGTI and their association with adverse pregnancy outcomes, Pre term birth (PTB) and Low birth weight (LBW). Methods A hospital based observational cohort study comprising 486 asymptomatic, antenatal women in the age group of 18-35 and the gestational period of 8-24 weeks was carried out. High vaginal and endocervical swabs were tested for Nugent's score, culture and PCR for Mycoplasmas and Chlamydia. All the women were followed until delivery. Results Prevalence of LGTI s among study population was 134(28%) comprising BV (2%), candidiasis (13%) , trichomoniasis(8%) and anaerobic vaginitis (9%). Nugent's scoring delineated study subjects as Grade I (84%), Grade II (14%) and Grade III (2%). Prevalence of various microbes were; G.vaginalis (2%), Candida sp (16%), anaerobic GNB (12%),anaerobic GPB (9%) and Mycoplasmas (8%). Prevalence of PTB and LBW were; 30(6%) and 59(13%) respectively. Presence of anaerobic GNB and GPB (Nugent's Grade II organisms) was statistically significant with both PTB(p = >0.01, 0.005) and LBW (p = 0.001, 0.026). Conclusion Incorporation of a simple diagnostic modality like Nugent's scoring system in antenatal care can help inearly diagnosis and management of asymptomatic LGTIs; thereby reduce associated adverse pregnancy outcomes.

UR - http://www.scopus.com/inward/record.url?scp=84971236486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971236486&partnerID=8YFLogxK

U2 - 10.1186/1471-2334-14-S3-E35

DO - 10.1186/1471-2334-14-S3-E35

M3 - Article

VL - 14

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

SN - 1471-2334

M1 - E35

ER -