Lymphatic drug transport and associated drug delivery technologies: A comprehensive review

Manjot S. Punjabi, Anup Naha, Disha Shetty, Usha Y. Nayak

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Lymphatic system is the secondary circulation system of the human body after the systemic circula-tion. Various problems, including the first-pass metabolism through oral administration of medicines, can be resolved by lymphatic targeting. Lymphatic absorption has been explored in detail, and studies reveal the improved bioavailability of medicines. In the case of cancer, AIDS, and various other health problems, lymphatic targeting has been focused on due to the fact that lymph nodes are involved greatly in tumor metastasis. This article reviews lymphatic absorption and its exploration in the treatment of various health problems. The physiology of the lymphatic system, the mechanisms of absorption, and the various formulation systems suitable for lymphatic absorption have been discussed. Some recent novel approaches like hydrodynamically driven device (HDD) and carbon nanotubes for lymphatic delivery have also been appraised.

Original languageEnglish
Pages (from-to)1992-1998
Number of pages7
JournalCurrent Pharmaceutical Design
Volume27
Issue number17
DOIs
Publication statusPublished - 06-2021

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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