Magnetic resonance evaluation of cerebral toxoplasmosis in patients with the acquired immunodeficiency syndrome

Arun Batra, R. P. Tripathi, S. P. Gorthi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: To evaluate and delineate the characteristics of cerebral toxoplasmosis lesions using a combination of magnetic resonance (MR) spectroscopy, diffusion, and perfusion studies. Material and Methods: A total of 8 patients with 23 lesions were evaluated on a 1.5-T MR system. Diffusion-weighted imaging (DWI) was performed with three 'b' values of 50, 500, and 1000 s/mm2, and the apparent diffusion coefficient maps were calculated. The diffusion-weighted appearances and the T2-weighted MR appearances of the lesions were compared. MR spectroscopy was performed using the point-resolved single-voxel technique with two TE values of 135ms and 270ms. Perfusion studies were carried out using the dynamic contrast-enhanced technique, and the relative cerebral blood volume maps were qualitatively and quantitatively analyzed. Results: DWI revealed the majority of the lesions as having increased diffusion within their necrotic centers, with the ADC ranging from 0.5 to 3.01 (mean ±SD: 1.49±.7). All the lesions revealed a predominant lipid peak on MR spectroscopy and were extremely hypovascular on perfusion MR studies. Conclusion: MR diffusion, spectroscopy, and perfusion studies help in characterizing toxoplasmosis lesions and, in most cases, can be used in combination to help establish the diagnosis of toxoplasmosis.

Original languageEnglish
Pages (from-to)212-221
Number of pages10
JournalActa Radiologica
Volume45
Issue number2
DOIs
Publication statusPublished - 01-04-2004

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Cerebral Toxoplasmosis
Acquired Immunodeficiency Syndrome
Magnetic Resonance Spectroscopy
Perfusion
Toxoplasmosis
Lipids

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

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Magnetic resonance evaluation of cerebral toxoplasmosis in patients with the acquired immunodeficiency syndrome. / Batra, Arun; Tripathi, R. P.; Gorthi, S. P.

In: Acta Radiologica, Vol. 45, No. 2, 01.04.2004, p. 212-221.

Research output: Contribution to journalArticle

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