Major electrocardiographic abnormalities and 25-hydroxy vitamin D deficiency

Insights from national health and nutrition examination survey-III

Tushar A. Tuliani, Maithili Shenoy, Abhishek Deshmukh, Ankit Rathod, Sadip Pant, Apurva O. Badheka, Diane Levine, Luis Afonso

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: We explored the relationship between major electrocardiogram (ECG) abnormalities (mECG) and 25-hydroxy (25-OH) vitamin D deficiency (VDD) and the effect of mECG abnormalities on all-cause and cardiovascular mortality in a healthy cohort with 25-OH vitamin D insufficiency and deficiency. Hypothesis: Lower levels of serum 25-OH vitamin D are associated with increased prevalence of mECG on resting ECG. Methods: We identified 5108 individuals from the National Health and Nutrition Examination Survey-III. mECG abnormalities included: major Q-QS wave abnormalities, ST depression/elevation, negative T waves, Wolff-Parkinson-White pattern, and ventricular conduction defect. Our cohort was divided into 3 groups based on 25-OH vitamin D levels: Group 1 (referent): >40 ng/mL; group 2 (insufficient): ≥20.01 to ≤40 ng/mL; and group 3 (deficient): ≤20 ng/mL. Logistic regression and Cox proportional hazards regression models were built. Results: The prevalence of major ECG abnormalities across 25-OH vitamin D sufficiency, insufficiency, and deficiency was 5.9%, 11%, and 13 %, respectively (P = 0.01). VDD was an independent predictor of mECG abnormalities after adjusting for traditional risk factors (continuous variable odds ratio [OR]: 0.98, 95% confidence interval [CI]: 0.97-0.99, P = 0.007; categorical variable group 3 vs group 1 OR: 2.36, 95% CI: 1.1-5.12, P = 0.03). Baseline major ECG abnormalities were predictive of long-term all-cause (hazard ratio [HR]:1.52, 95% CI: 1.23-1.89), composite cardiovascular (HR: 1.7, 95% CI: 1.34-2.15), cardiovascular (HR: 1.64, 95% CI: 1.27-2.12), and ischemic heart disease mortality (HR: 1.98, 95% CI: 1.46-2.69) in individuals with 25-OH vitamin D levels ≤40 ng/mL. Conclusions: VDD is associated with increased prevalence of major ECG abnormalities. Well-structured trials are needed to assess progression/resolution of mECG abnormalities with vitamin D supplementation in deficient individuals.

Original languageEnglish
Pages (from-to)660-666
Number of pages7
JournalClinical Cardiology
Volume37
Issue number11
DOIs
Publication statusPublished - 01-01-2014
Externally publishedYes

Fingerprint

Vitamin D Deficiency
Nutrition Surveys
Vitamin D
Confidence Intervals
Electrocardiography
Odds Ratio
Mortality
Proportional Hazards Models
Myocardial Ischemia
Logistic Models
Serum

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Tuliani, Tushar A. ; Shenoy, Maithili ; Deshmukh, Abhishek ; Rathod, Ankit ; Pant, Sadip ; Badheka, Apurva O. ; Levine, Diane ; Afonso, Luis. / Major electrocardiographic abnormalities and 25-hydroxy vitamin D deficiency : Insights from national health and nutrition examination survey-III. In: Clinical Cardiology. 2014 ; Vol. 37, No. 11. pp. 660-666.
@article{f69084887f224d14ac8bcf07b1f1fc5d,
title = "Major electrocardiographic abnormalities and 25-hydroxy vitamin D deficiency: Insights from national health and nutrition examination survey-III",
abstract = "Background: We explored the relationship between major electrocardiogram (ECG) abnormalities (mECG) and 25-hydroxy (25-OH) vitamin D deficiency (VDD) and the effect of mECG abnormalities on all-cause and cardiovascular mortality in a healthy cohort with 25-OH vitamin D insufficiency and deficiency. Hypothesis: Lower levels of serum 25-OH vitamin D are associated with increased prevalence of mECG on resting ECG. Methods: We identified 5108 individuals from the National Health and Nutrition Examination Survey-III. mECG abnormalities included: major Q-QS wave abnormalities, ST depression/elevation, negative T waves, Wolff-Parkinson-White pattern, and ventricular conduction defect. Our cohort was divided into 3 groups based on 25-OH vitamin D levels: Group 1 (referent): >40 ng/mL; group 2 (insufficient): ≥20.01 to ≤40 ng/mL; and group 3 (deficient): ≤20 ng/mL. Logistic regression and Cox proportional hazards regression models were built. Results: The prevalence of major ECG abnormalities across 25-OH vitamin D sufficiency, insufficiency, and deficiency was 5.9{\%}, 11{\%}, and 13 {\%}, respectively (P = 0.01). VDD was an independent predictor of mECG abnormalities after adjusting for traditional risk factors (continuous variable odds ratio [OR]: 0.98, 95{\%} confidence interval [CI]: 0.97-0.99, P = 0.007; categorical variable group 3 vs group 1 OR: 2.36, 95{\%} CI: 1.1-5.12, P = 0.03). Baseline major ECG abnormalities were predictive of long-term all-cause (hazard ratio [HR]:1.52, 95{\%} CI: 1.23-1.89), composite cardiovascular (HR: 1.7, 95{\%} CI: 1.34-2.15), cardiovascular (HR: 1.64, 95{\%} CI: 1.27-2.12), and ischemic heart disease mortality (HR: 1.98, 95{\%} CI: 1.46-2.69) in individuals with 25-OH vitamin D levels ≤40 ng/mL. Conclusions: VDD is associated with increased prevalence of major ECG abnormalities. Well-structured trials are needed to assess progression/resolution of mECG abnormalities with vitamin D supplementation in deficient individuals.",
author = "Tuliani, {Tushar A.} and Maithili Shenoy and Abhishek Deshmukh and Ankit Rathod and Sadip Pant and Badheka, {Apurva O.} and Diane Levine and Luis Afonso",
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Tuliani, TA, Shenoy, M, Deshmukh, A, Rathod, A, Pant, S, Badheka, AO, Levine, D & Afonso, L 2014, 'Major electrocardiographic abnormalities and 25-hydroxy vitamin D deficiency: Insights from national health and nutrition examination survey-III', Clinical Cardiology, vol. 37, no. 11, pp. 660-666. https://doi.org/10.1002/clc.22329

Major electrocardiographic abnormalities and 25-hydroxy vitamin D deficiency : Insights from national health and nutrition examination survey-III. / Tuliani, Tushar A.; Shenoy, Maithili; Deshmukh, Abhishek; Rathod, Ankit; Pant, Sadip; Badheka, Apurva O.; Levine, Diane; Afonso, Luis.

In: Clinical Cardiology, Vol. 37, No. 11, 01.01.2014, p. 660-666.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Major electrocardiographic abnormalities and 25-hydroxy vitamin D deficiency

T2 - Insights from national health and nutrition examination survey-III

AU - Tuliani, Tushar A.

AU - Shenoy, Maithili

AU - Deshmukh, Abhishek

AU - Rathod, Ankit

AU - Pant, Sadip

AU - Badheka, Apurva O.

AU - Levine, Diane

AU - Afonso, Luis

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: We explored the relationship between major electrocardiogram (ECG) abnormalities (mECG) and 25-hydroxy (25-OH) vitamin D deficiency (VDD) and the effect of mECG abnormalities on all-cause and cardiovascular mortality in a healthy cohort with 25-OH vitamin D insufficiency and deficiency. Hypothesis: Lower levels of serum 25-OH vitamin D are associated with increased prevalence of mECG on resting ECG. Methods: We identified 5108 individuals from the National Health and Nutrition Examination Survey-III. mECG abnormalities included: major Q-QS wave abnormalities, ST depression/elevation, negative T waves, Wolff-Parkinson-White pattern, and ventricular conduction defect. Our cohort was divided into 3 groups based on 25-OH vitamin D levels: Group 1 (referent): >40 ng/mL; group 2 (insufficient): ≥20.01 to ≤40 ng/mL; and group 3 (deficient): ≤20 ng/mL. Logistic regression and Cox proportional hazards regression models were built. Results: The prevalence of major ECG abnormalities across 25-OH vitamin D sufficiency, insufficiency, and deficiency was 5.9%, 11%, and 13 %, respectively (P = 0.01). VDD was an independent predictor of mECG abnormalities after adjusting for traditional risk factors (continuous variable odds ratio [OR]: 0.98, 95% confidence interval [CI]: 0.97-0.99, P = 0.007; categorical variable group 3 vs group 1 OR: 2.36, 95% CI: 1.1-5.12, P = 0.03). Baseline major ECG abnormalities were predictive of long-term all-cause (hazard ratio [HR]:1.52, 95% CI: 1.23-1.89), composite cardiovascular (HR: 1.7, 95% CI: 1.34-2.15), cardiovascular (HR: 1.64, 95% CI: 1.27-2.12), and ischemic heart disease mortality (HR: 1.98, 95% CI: 1.46-2.69) in individuals with 25-OH vitamin D levels ≤40 ng/mL. Conclusions: VDD is associated with increased prevalence of major ECG abnormalities. Well-structured trials are needed to assess progression/resolution of mECG abnormalities with vitamin D supplementation in deficient individuals.

AB - Background: We explored the relationship between major electrocardiogram (ECG) abnormalities (mECG) and 25-hydroxy (25-OH) vitamin D deficiency (VDD) and the effect of mECG abnormalities on all-cause and cardiovascular mortality in a healthy cohort with 25-OH vitamin D insufficiency and deficiency. Hypothesis: Lower levels of serum 25-OH vitamin D are associated with increased prevalence of mECG on resting ECG. Methods: We identified 5108 individuals from the National Health and Nutrition Examination Survey-III. mECG abnormalities included: major Q-QS wave abnormalities, ST depression/elevation, negative T waves, Wolff-Parkinson-White pattern, and ventricular conduction defect. Our cohort was divided into 3 groups based on 25-OH vitamin D levels: Group 1 (referent): >40 ng/mL; group 2 (insufficient): ≥20.01 to ≤40 ng/mL; and group 3 (deficient): ≤20 ng/mL. Logistic regression and Cox proportional hazards regression models were built. Results: The prevalence of major ECG abnormalities across 25-OH vitamin D sufficiency, insufficiency, and deficiency was 5.9%, 11%, and 13 %, respectively (P = 0.01). VDD was an independent predictor of mECG abnormalities after adjusting for traditional risk factors (continuous variable odds ratio [OR]: 0.98, 95% confidence interval [CI]: 0.97-0.99, P = 0.007; categorical variable group 3 vs group 1 OR: 2.36, 95% CI: 1.1-5.12, P = 0.03). Baseline major ECG abnormalities were predictive of long-term all-cause (hazard ratio [HR]:1.52, 95% CI: 1.23-1.89), composite cardiovascular (HR: 1.7, 95% CI: 1.34-2.15), cardiovascular (HR: 1.64, 95% CI: 1.27-2.12), and ischemic heart disease mortality (HR: 1.98, 95% CI: 1.46-2.69) in individuals with 25-OH vitamin D levels ≤40 ng/mL. Conclusions: VDD is associated with increased prevalence of major ECG abnormalities. Well-structured trials are needed to assess progression/resolution of mECG abnormalities with vitamin D supplementation in deficient individuals.

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