Malaria Severity in Mangaluru City in the Southwestern Coastal Region of India

Kiran K. Dayanand, Punnath Kishore, Valleesha Chandrashekar, Rajeshwara N. Achur, Susanta K. Ghosh, Srinivas B. Kakkilaya, Suchetha N. Kumari, Satyanarayan Tiwari, Archith Boloor, Rajeshwari Devi, D. Channe Gowda

Research output: Contribution to journalArticle

Abstract

Dakshina Kannada district in the Southwestern region of Karnataka state, India, including Mangaluru city is endemic to malaria. About 80% of malaria infections in Mangaluru and its surrounding areas are caused by Plasmodium vivax and the remainder is due to Plasmodium falciparum. Malaria-associated clinical complications significantly occur in this region. Here, we report the pathological conditions of 41 cases of fatal severe malaria, admitted to the district government hospital in Mangaluru city during January 2013 through December 2016. The results of clinical, hematological, and biochemical analyses showed that most of these severe malaria cases were associated with thrombocytopenia, anemia, metabolic acidosis, acute respiratory distress, and single or multi-organ dysfunction involving liver, kidney, and brain. Of the 41 fatal malaria cases, 24, 10, and seven patients had P. vivax, P. falciparum, and P. vivax and P. falciparum mixed infections, respectively. These data suggest that besides P. falciparum that is known to extensively cause severe and fatal malaria illnesses, P. vivax causes fatal illnesses substantially in this region, an observation that is consistent with recent findings in other regions.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalThe American journal of tropical medicine and hygiene
Volume100
Issue number2
DOIs
Publication statusPublished - 01-02-2019

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Malaria
India
Plasmodium falciparum
Plasmodium vivax
Vivax Malaria
District Hospitals
Acidosis
Coinfection
Thrombocytopenia
Liver Diseases
Anemia
Observation
Kidney
Brain
Infection

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Dayanand, K. K., Kishore, P., Chandrashekar, V., Achur, R. N., Ghosh, S. K., Kakkilaya, S. B., ... Gowda, D. C. (2019). Malaria Severity in Mangaluru City in the Southwestern Coastal Region of India. The American journal of tropical medicine and hygiene, 100(2), 275-279. https://doi.org/10.4269/ajtmh.18-0005
Dayanand, Kiran K. ; Kishore, Punnath ; Chandrashekar, Valleesha ; Achur, Rajeshwara N. ; Ghosh, Susanta K. ; Kakkilaya, Srinivas B. ; Kumari, Suchetha N. ; Tiwari, Satyanarayan ; Boloor, Archith ; Devi, Rajeshwari ; Gowda, D. Channe. / Malaria Severity in Mangaluru City in the Southwestern Coastal Region of India. In: The American journal of tropical medicine and hygiene. 2019 ; Vol. 100, No. 2. pp. 275-279.
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Dayanand, KK, Kishore, P, Chandrashekar, V, Achur, RN, Ghosh, SK, Kakkilaya, SB, Kumari, SN, Tiwari, S, Boloor, A, Devi, R & Gowda, DC 2019, 'Malaria Severity in Mangaluru City in the Southwestern Coastal Region of India', The American journal of tropical medicine and hygiene, vol. 100, no. 2, pp. 275-279. https://doi.org/10.4269/ajtmh.18-0005

Malaria Severity in Mangaluru City in the Southwestern Coastal Region of India. / Dayanand, Kiran K.; Kishore, Punnath; Chandrashekar, Valleesha; Achur, Rajeshwara N.; Ghosh, Susanta K.; Kakkilaya, Srinivas B.; Kumari, Suchetha N.; Tiwari, Satyanarayan; Boloor, Archith; Devi, Rajeshwari; Gowda, D. Channe.

In: The American journal of tropical medicine and hygiene, Vol. 100, No. 2, 01.02.2019, p. 275-279.

Research output: Contribution to journalArticle

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AU - Ghosh, Susanta K.

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AU - Devi, Rajeshwari

AU - Gowda, D. Channe

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N2 - Dakshina Kannada district in the Southwestern region of Karnataka state, India, including Mangaluru city is endemic to malaria. About 80% of malaria infections in Mangaluru and its surrounding areas are caused by Plasmodium vivax and the remainder is due to Plasmodium falciparum. Malaria-associated clinical complications significantly occur in this region. Here, we report the pathological conditions of 41 cases of fatal severe malaria, admitted to the district government hospital in Mangaluru city during January 2013 through December 2016. The results of clinical, hematological, and biochemical analyses showed that most of these severe malaria cases were associated with thrombocytopenia, anemia, metabolic acidosis, acute respiratory distress, and single or multi-organ dysfunction involving liver, kidney, and brain. Of the 41 fatal malaria cases, 24, 10, and seven patients had P. vivax, P. falciparum, and P. vivax and P. falciparum mixed infections, respectively. These data suggest that besides P. falciparum that is known to extensively cause severe and fatal malaria illnesses, P. vivax causes fatal illnesses substantially in this region, an observation that is consistent with recent findings in other regions.

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Dayanand KK, Kishore P, Chandrashekar V, Achur RN, Ghosh SK, Kakkilaya SB et al. Malaria Severity in Mangaluru City in the Southwestern Coastal Region of India. The American journal of tropical medicine and hygiene. 2019 Feb 1;100(2):275-279. https://doi.org/10.4269/ajtmh.18-0005