Management of patients refractory to platelet transfusion

Porselvi Chockalingam, Ronald A. Sacher

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


This article discusses the causes and management of platelet refractoriness. Improvements in the quality of platelets and leukoreduction have reduced the morbidity and mortality related to alloimmunization and refractoriness of patients to platelet transfusion. Alloimmunization can be distinguished from other causes of poor post-transfusion platelet increments by the measurement of platelet alloantibodies. Options for managing platelet refractoriness caused by alloimmunization include platelet transfusion from human leukocyte antigen-matched or donor-recipient cross-matched platelets. Prevention strategies include efforts to limit recipients' exposure to human leukocyte antigen specificities by using single-donor platelets, filtration to reduce the number of human leukocyte antigen-bearing leukocytes, and pretransfusion ultraviolet B irradiation to decrease their immunogenicity. For appropriate management of patients refractory to platelets, close cooperation and good communication are necessary between clinicians and blood centers.

Original languageEnglish
Pages (from-to)220-225
Number of pages6
JournalJournal of Infusion Nursing
Issue number4
Publication statusPublished - 01-07-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Nursing(all)


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