Mangiferin, a glucosylxanthone, protects against the radiation-induced micronuclei formation in the cultured human peripheral blood lymphocytes

Ganesh Chandra Jagetia, V. A. Venkatesha

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effect of mangiferin (MGN), a glucosylxanthone, derived from Mangifera indica was studied on the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes (HPBLs) by micronucleus assay, where HPBLs were treated with 0, 5, 10, 20, 50, 100 μg/ml of mangiferin 30 min before exposure to 3 Gy of 60Co γ-radiation. Treatment of HPBLs with 50 μg/ml reduced the radiation-induced micronuclei to the maximum extent. Irradiation of HPBLs to 0, 1, 2, 3, or 4 Gy resulted in a dose-dependent increase in the frequency of micronuclei, while treatment of HPBLs with 50 μg/ml MGN before exposure to 0, 1, 2, 3, or 4 Gy of 60Co γ-radiation resulted in a significant decline in the frequency of micronuclei when compared with the untreated irradiation group.

Original languageEnglish
Pages (from-to)195-196
Number of pages2
JournalInternational Congress Series
Volume1276
DOIs
Publication statusPublished - 01-02-2005
Externally publishedYes

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Lymphocytes
Radiation
Radiation Dosage
Mangifera
Micronucleus Tests
DNA Damage
mangiferin

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Mangiferin, a glucosylxanthone, protects against the radiation-induced micronuclei formation in the cultured human peripheral blood lymphocytes",
abstract = "The effect of mangiferin (MGN), a glucosylxanthone, derived from Mangifera indica was studied on the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes (HPBLs) by micronucleus assay, where HPBLs were treated with 0, 5, 10, 20, 50, 100 μg/ml of mangiferin 30 min before exposure to 3 Gy of 60Co γ-radiation. Treatment of HPBLs with 50 μg/ml reduced the radiation-induced micronuclei to the maximum extent. Irradiation of HPBLs to 0, 1, 2, 3, or 4 Gy resulted in a dose-dependent increase in the frequency of micronuclei, while treatment of HPBLs with 50 μg/ml MGN before exposure to 0, 1, 2, 3, or 4 Gy of 60Co γ-radiation resulted in a significant decline in the frequency of micronuclei when compared with the untreated irradiation group.",
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Mangiferin, a glucosylxanthone, protects against the radiation-induced micronuclei formation in the cultured human peripheral blood lymphocytes. / Jagetia, Ganesh Chandra; Venkatesha, V. A.

In: International Congress Series, Vol. 1276, 01.02.2005, p. 195-196.

Research output: Contribution to journalArticle

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