Manifestation of malaria in Mangaluru, southern India

Prabhanjan P. Gai, Frank P. Mockenhaupt, Konrad Siegert, Jakob Wedam, Archith Boloor, Suyamindra S. Kulkarni, Rashmi Rasalkar, Arun Kumar, Animesh Jain, Chakrapani Mahabala, Pramod Gai, Shantaram Baliga, Rajeshwari Devi, Damodara Shenoy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Severe and fatal vivax malaria is increasingly reported from India. In Mangaluru, southern India, malaria is focused in urban areas and associated with importation by migrant workers. In Wenlock Hospital, the largest governmental hospital, the clinical, parasitological and biochemical characteristics of malaria patients were assessed. Methods: During the peak malaria season in 2015 (June to December), outpatients were interviewed and clinically assessed. Malaria was ascertained by microscopy and PCR assays, concentrations of haemoglobin, creatinine and bilirubin, as well as thrombocyte count, were determined, and severe malaria was defined according to WHO criteria. Results: Among 909 malaria patients, the vast majority was male (93%), adult (median, 26 years) and of low socio-economic status. Roughly half of them were migrants from beyond the local Karnataka state, mostly from northern and northeastern states. Vivax malaria (69.6%) predominated over mixed Plasmodium vivax-Plasmodium falciparum infection (21.3%) and falciparum malaria (9.0%). The geometric mean parasite density was 3412/μL. As compared to vivax malaria, patients with falciparum malaria had higher parasite density and more frequently showed impaired general condition, affected consciousness and splenomegaly. Also, they tended to more commonly have anaemia and increased creatinine levels, and to be hospitalized (7.3%). Mixed-species infections largely assumed an interim position. Severe malaria (3.5%) was not associated with parasite species. No fatality occurred. Conclusion: In this study, uncomplicated cases of malaria predominated, with P. falciparum causing slightly more intense manifestation. Severe malaria was infrequent and fatalities absent. This contrasts with the reported pattern of manifestation in other parts of India, which requires the analysis of underlying causes.

Original languageEnglish
Article number313
JournalMalaria Journal
Volume17
Issue number1
DOIs
Publication statusPublished - 29-08-2018

Fingerprint

Malaria
India
Vivax Malaria
Parasites
Falciparum Malaria
Plasmodium falciparum
Creatinine
Plasmodium vivax
Splenomegaly
Consciousness
Coinfection
Bilirubin
Anemia
Microscopy
Hemoglobins
Outpatients
Blood Platelets
Economics
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

Cite this

Gai, P. P., Mockenhaupt, F. P., Siegert, K., Wedam, J., Boloor, A., Kulkarni, S. S., ... Shenoy, D. (2018). Manifestation of malaria in Mangaluru, southern India. Malaria Journal, 17(1), [313]. https://doi.org/10.1186/s12936-018-2462-7
Gai, Prabhanjan P. ; Mockenhaupt, Frank P. ; Siegert, Konrad ; Wedam, Jakob ; Boloor, Archith ; Kulkarni, Suyamindra S. ; Rasalkar, Rashmi ; Kumar, Arun ; Jain, Animesh ; Mahabala, Chakrapani ; Gai, Pramod ; Baliga, Shantaram ; Devi, Rajeshwari ; Shenoy, Damodara. / Manifestation of malaria in Mangaluru, southern India. In: Malaria Journal. 2018 ; Vol. 17, No. 1.
@article{ed853122f4ab47c5a7f0a7297ad99cfa,
title = "Manifestation of malaria in Mangaluru, southern India",
abstract = "Background: Severe and fatal vivax malaria is increasingly reported from India. In Mangaluru, southern India, malaria is focused in urban areas and associated with importation by migrant workers. In Wenlock Hospital, the largest governmental hospital, the clinical, parasitological and biochemical characteristics of malaria patients were assessed. Methods: During the peak malaria season in 2015 (June to December), outpatients were interviewed and clinically assessed. Malaria was ascertained by microscopy and PCR assays, concentrations of haemoglobin, creatinine and bilirubin, as well as thrombocyte count, were determined, and severe malaria was defined according to WHO criteria. Results: Among 909 malaria patients, the vast majority was male (93{\%}), adult (median, 26 years) and of low socio-economic status. Roughly half of them were migrants from beyond the local Karnataka state, mostly from northern and northeastern states. Vivax malaria (69.6{\%}) predominated over mixed Plasmodium vivax-Plasmodium falciparum infection (21.3{\%}) and falciparum malaria (9.0{\%}). The geometric mean parasite density was 3412/μL. As compared to vivax malaria, patients with falciparum malaria had higher parasite density and more frequently showed impaired general condition, affected consciousness and splenomegaly. Also, they tended to more commonly have anaemia and increased creatinine levels, and to be hospitalized (7.3{\%}). Mixed-species infections largely assumed an interim position. Severe malaria (3.5{\%}) was not associated with parasite species. No fatality occurred. Conclusion: In this study, uncomplicated cases of malaria predominated, with P. falciparum causing slightly more intense manifestation. Severe malaria was infrequent and fatalities absent. This contrasts with the reported pattern of manifestation in other parts of India, which requires the analysis of underlying causes.",
author = "Gai, {Prabhanjan P.} and Mockenhaupt, {Frank P.} and Konrad Siegert and Jakob Wedam and Archith Boloor and Kulkarni, {Suyamindra S.} and Rashmi Rasalkar and Arun Kumar and Animesh Jain and Chakrapani Mahabala and Pramod Gai and Shantaram Baliga and Rajeshwari Devi and Damodara Shenoy",
year = "2018",
month = "8",
day = "29",
doi = "10.1186/s12936-018-2462-7",
language = "English",
volume = "17",
journal = "Malaria Journal",
issn = "1475-2875",
publisher = "BioMed Central",
number = "1",

}

Gai, PP, Mockenhaupt, FP, Siegert, K, Wedam, J, Boloor, A, Kulkarni, SS, Rasalkar, R, Kumar, A, Jain, A, Mahabala, C, Gai, P, Baliga, S, Devi, R & Shenoy, D 2018, 'Manifestation of malaria in Mangaluru, southern India', Malaria Journal, vol. 17, no. 1, 313. https://doi.org/10.1186/s12936-018-2462-7

Manifestation of malaria in Mangaluru, southern India. / Gai, Prabhanjan P.; Mockenhaupt, Frank P.; Siegert, Konrad; Wedam, Jakob; Boloor, Archith; Kulkarni, Suyamindra S.; Rasalkar, Rashmi; Kumar, Arun; Jain, Animesh; Mahabala, Chakrapani; Gai, Pramod; Baliga, Shantaram; Devi, Rajeshwari; Shenoy, Damodara.

In: Malaria Journal, Vol. 17, No. 1, 313, 29.08.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Manifestation of malaria in Mangaluru, southern India

AU - Gai, Prabhanjan P.

AU - Mockenhaupt, Frank P.

AU - Siegert, Konrad

AU - Wedam, Jakob

AU - Boloor, Archith

AU - Kulkarni, Suyamindra S.

AU - Rasalkar, Rashmi

AU - Kumar, Arun

AU - Jain, Animesh

AU - Mahabala, Chakrapani

AU - Gai, Pramod

AU - Baliga, Shantaram

AU - Devi, Rajeshwari

AU - Shenoy, Damodara

PY - 2018/8/29

Y1 - 2018/8/29

N2 - Background: Severe and fatal vivax malaria is increasingly reported from India. In Mangaluru, southern India, malaria is focused in urban areas and associated with importation by migrant workers. In Wenlock Hospital, the largest governmental hospital, the clinical, parasitological and biochemical characteristics of malaria patients were assessed. Methods: During the peak malaria season in 2015 (June to December), outpatients were interviewed and clinically assessed. Malaria was ascertained by microscopy and PCR assays, concentrations of haemoglobin, creatinine and bilirubin, as well as thrombocyte count, were determined, and severe malaria was defined according to WHO criteria. Results: Among 909 malaria patients, the vast majority was male (93%), adult (median, 26 years) and of low socio-economic status. Roughly half of them were migrants from beyond the local Karnataka state, mostly from northern and northeastern states. Vivax malaria (69.6%) predominated over mixed Plasmodium vivax-Plasmodium falciparum infection (21.3%) and falciparum malaria (9.0%). The geometric mean parasite density was 3412/μL. As compared to vivax malaria, patients with falciparum malaria had higher parasite density and more frequently showed impaired general condition, affected consciousness and splenomegaly. Also, they tended to more commonly have anaemia and increased creatinine levels, and to be hospitalized (7.3%). Mixed-species infections largely assumed an interim position. Severe malaria (3.5%) was not associated with parasite species. No fatality occurred. Conclusion: In this study, uncomplicated cases of malaria predominated, with P. falciparum causing slightly more intense manifestation. Severe malaria was infrequent and fatalities absent. This contrasts with the reported pattern of manifestation in other parts of India, which requires the analysis of underlying causes.

AB - Background: Severe and fatal vivax malaria is increasingly reported from India. In Mangaluru, southern India, malaria is focused in urban areas and associated with importation by migrant workers. In Wenlock Hospital, the largest governmental hospital, the clinical, parasitological and biochemical characteristics of malaria patients were assessed. Methods: During the peak malaria season in 2015 (June to December), outpatients were interviewed and clinically assessed. Malaria was ascertained by microscopy and PCR assays, concentrations of haemoglobin, creatinine and bilirubin, as well as thrombocyte count, were determined, and severe malaria was defined according to WHO criteria. Results: Among 909 malaria patients, the vast majority was male (93%), adult (median, 26 years) and of low socio-economic status. Roughly half of them were migrants from beyond the local Karnataka state, mostly from northern and northeastern states. Vivax malaria (69.6%) predominated over mixed Plasmodium vivax-Plasmodium falciparum infection (21.3%) and falciparum malaria (9.0%). The geometric mean parasite density was 3412/μL. As compared to vivax malaria, patients with falciparum malaria had higher parasite density and more frequently showed impaired general condition, affected consciousness and splenomegaly. Also, they tended to more commonly have anaemia and increased creatinine levels, and to be hospitalized (7.3%). Mixed-species infections largely assumed an interim position. Severe malaria (3.5%) was not associated with parasite species. No fatality occurred. Conclusion: In this study, uncomplicated cases of malaria predominated, with P. falciparum causing slightly more intense manifestation. Severe malaria was infrequent and fatalities absent. This contrasts with the reported pattern of manifestation in other parts of India, which requires the analysis of underlying causes.

UR - http://www.scopus.com/inward/record.url?scp=85052727878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052727878&partnerID=8YFLogxK

U2 - 10.1186/s12936-018-2462-7

DO - 10.1186/s12936-018-2462-7

M3 - Article

AN - SCOPUS:85052727878

VL - 17

JO - Malaria Journal

JF - Malaria Journal

SN - 1475-2875

IS - 1

M1 - 313

ER -

Gai PP, Mockenhaupt FP, Siegert K, Wedam J, Boloor A, Kulkarni SS et al. Manifestation of malaria in Mangaluru, southern India. Malaria Journal. 2018 Aug 29;17(1). 313. https://doi.org/10.1186/s12936-018-2462-7