Manipal lifestyle modification score to predict major adverse cardiac events in postcoronary angioplasty patients

Tom Devasia, Prasad Narayana Shetty, Hashir Kareem, Yeswanth Rao Karkala, Ajit Singh

Research output: Contribution to journalArticle

Abstract

Background: Lifestyle modification (LSM) such as prudent diet, physical activity, avoidance of smoking, and maintaining a healthy weight may considerably decrease the risk for coronary artery disease. Objective: The primary objective of this study was to develop a new LSM scoring system and investigate the correlation between adherence to LSM and incidence of major adverse cardiac events (MACEs) at 12-month follow-up. Method: A total of 1000 consecutive patients who underwent percutaneous transluminal coronary angioplasty (PTCA) were included in this prospective single-center study. Manipal lifestyle modification score (MLSMS) was developed by using five lifestyle-related factors. Adherence to LSM at the baseline and subsequent follow-ups was determined by using MLSMS. The MACE at 1-, 6-, and 12-month follow-up were analyzed. Results: There was a significant reduction in overall adherence to LSM (p < 0.001) at 12-month follow-up. Nonadherence to LSM [hazard ratio (HR) 0.575; 95% confidence interval (CI) 0.334–0.990; p < 0.046] and noncompliance to medication (HR 2.09; 95% CI 1.425–3.072; p < 0.001) were independent predictors of MACEs after PTCA. The cumulative MACE was 15.4%, which includes 4.9% of all-cause death, 5.2% of nonfatal myocardial infarction, 2.0% of target lesion revascularization, 1.8% of target vessel revascularization, and 1.3% of stroke at 12 months. The incidence of MACEs at 12 months was significantly (p = 0.03) higher in LSM nonadherent compared with LSM adherent patients. Conclusion: There is an overall reduction in adherence to LSM on successive follow-ups and a significant association between the incidence of MACEs and the lack of adherence to LSM. MLSMS is a simple and effective evaluation tool in predicting MACEs in this group of patients.

Original languageEnglish
Pages (from-to)S353-S358
JournalIndian Heart Journal
Volume70
DOIs
Publication statusPublished - 01-12-2018

Fingerprint

Angioplasty
Life Style
Coronary Balloon Angioplasty
Incidence
Confidence Intervals
Medication Adherence
Coronary Artery Disease
Cause of Death
Smoking
Stroke
Myocardial Infarction
Exercise

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Devasia, Tom ; Shetty, Prasad Narayana ; Kareem, Hashir ; Karkala, Yeswanth Rao ; Singh, Ajit. / Manipal lifestyle modification score to predict major adverse cardiac events in postcoronary angioplasty patients. In: Indian Heart Journal. 2018 ; Vol. 70. pp. S353-S358.
@article{049d60afa63340b498ecd9c5e4f135b2,
title = "Manipal lifestyle modification score to predict major adverse cardiac events in postcoronary angioplasty patients",
abstract = "Background: Lifestyle modification (LSM) such as prudent diet, physical activity, avoidance of smoking, and maintaining a healthy weight may considerably decrease the risk for coronary artery disease. Objective: The primary objective of this study was to develop a new LSM scoring system and investigate the correlation between adherence to LSM and incidence of major adverse cardiac events (MACEs) at 12-month follow-up. Method: A total of 1000 consecutive patients who underwent percutaneous transluminal coronary angioplasty (PTCA) were included in this prospective single-center study. Manipal lifestyle modification score (MLSMS) was developed by using five lifestyle-related factors. Adherence to LSM at the baseline and subsequent follow-ups was determined by using MLSMS. The MACE at 1-, 6-, and 12-month follow-up were analyzed. Results: There was a significant reduction in overall adherence to LSM (p < 0.001) at 12-month follow-up. Nonadherence to LSM [hazard ratio (HR) 0.575; 95{\%} confidence interval (CI) 0.334–0.990; p < 0.046] and noncompliance to medication (HR 2.09; 95{\%} CI 1.425–3.072; p < 0.001) were independent predictors of MACEs after PTCA. The cumulative MACE was 15.4{\%}, which includes 4.9{\%} of all-cause death, 5.2{\%} of nonfatal myocardial infarction, 2.0{\%} of target lesion revascularization, 1.8{\%} of target vessel revascularization, and 1.3{\%} of stroke at 12 months. The incidence of MACEs at 12 months was significantly (p = 0.03) higher in LSM nonadherent compared with LSM adherent patients. Conclusion: There is an overall reduction in adherence to LSM on successive follow-ups and a significant association between the incidence of MACEs and the lack of adherence to LSM. MLSMS is a simple and effective evaluation tool in predicting MACEs in this group of patients.",
author = "Tom Devasia and Shetty, {Prasad Narayana} and Hashir Kareem and Karkala, {Yeswanth Rao} and Ajit Singh",
year = "2018",
month = "12",
day = "1",
doi = "10.1016/j.ihj.2018.10.411",
language = "English",
volume = "70",
pages = "S353--S358",
journal = "Indian Heart Journal",
issn = "0019-4832",
publisher = "Cardiology Society of India",

}

Manipal lifestyle modification score to predict major adverse cardiac events in postcoronary angioplasty patients. / Devasia, Tom; Shetty, Prasad Narayana; Kareem, Hashir; Karkala, Yeswanth Rao; Singh, Ajit.

In: Indian Heart Journal, Vol. 70, 01.12.2018, p. S353-S358.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Manipal lifestyle modification score to predict major adverse cardiac events in postcoronary angioplasty patients

AU - Devasia, Tom

AU - Shetty, Prasad Narayana

AU - Kareem, Hashir

AU - Karkala, Yeswanth Rao

AU - Singh, Ajit

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: Lifestyle modification (LSM) such as prudent diet, physical activity, avoidance of smoking, and maintaining a healthy weight may considerably decrease the risk for coronary artery disease. Objective: The primary objective of this study was to develop a new LSM scoring system and investigate the correlation between adherence to LSM and incidence of major adverse cardiac events (MACEs) at 12-month follow-up. Method: A total of 1000 consecutive patients who underwent percutaneous transluminal coronary angioplasty (PTCA) were included in this prospective single-center study. Manipal lifestyle modification score (MLSMS) was developed by using five lifestyle-related factors. Adherence to LSM at the baseline and subsequent follow-ups was determined by using MLSMS. The MACE at 1-, 6-, and 12-month follow-up were analyzed. Results: There was a significant reduction in overall adherence to LSM (p < 0.001) at 12-month follow-up. Nonadherence to LSM [hazard ratio (HR) 0.575; 95% confidence interval (CI) 0.334–0.990; p < 0.046] and noncompliance to medication (HR 2.09; 95% CI 1.425–3.072; p < 0.001) were independent predictors of MACEs after PTCA. The cumulative MACE was 15.4%, which includes 4.9% of all-cause death, 5.2% of nonfatal myocardial infarction, 2.0% of target lesion revascularization, 1.8% of target vessel revascularization, and 1.3% of stroke at 12 months. The incidence of MACEs at 12 months was significantly (p = 0.03) higher in LSM nonadherent compared with LSM adherent patients. Conclusion: There is an overall reduction in adherence to LSM on successive follow-ups and a significant association between the incidence of MACEs and the lack of adherence to LSM. MLSMS is a simple and effective evaluation tool in predicting MACEs in this group of patients.

AB - Background: Lifestyle modification (LSM) such as prudent diet, physical activity, avoidance of smoking, and maintaining a healthy weight may considerably decrease the risk for coronary artery disease. Objective: The primary objective of this study was to develop a new LSM scoring system and investigate the correlation between adherence to LSM and incidence of major adverse cardiac events (MACEs) at 12-month follow-up. Method: A total of 1000 consecutive patients who underwent percutaneous transluminal coronary angioplasty (PTCA) were included in this prospective single-center study. Manipal lifestyle modification score (MLSMS) was developed by using five lifestyle-related factors. Adherence to LSM at the baseline and subsequent follow-ups was determined by using MLSMS. The MACE at 1-, 6-, and 12-month follow-up were analyzed. Results: There was a significant reduction in overall adherence to LSM (p < 0.001) at 12-month follow-up. Nonadherence to LSM [hazard ratio (HR) 0.575; 95% confidence interval (CI) 0.334–0.990; p < 0.046] and noncompliance to medication (HR 2.09; 95% CI 1.425–3.072; p < 0.001) were independent predictors of MACEs after PTCA. The cumulative MACE was 15.4%, which includes 4.9% of all-cause death, 5.2% of nonfatal myocardial infarction, 2.0% of target lesion revascularization, 1.8% of target vessel revascularization, and 1.3% of stroke at 12 months. The incidence of MACEs at 12 months was significantly (p = 0.03) higher in LSM nonadherent compared with LSM adherent patients. Conclusion: There is an overall reduction in adherence to LSM on successive follow-ups and a significant association between the incidence of MACEs and the lack of adherence to LSM. MLSMS is a simple and effective evaluation tool in predicting MACEs in this group of patients.

UR - http://www.scopus.com/inward/record.url?scp=85057010160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057010160&partnerID=8YFLogxK

U2 - 10.1016/j.ihj.2018.10.411

DO - 10.1016/j.ihj.2018.10.411

M3 - Article

VL - 70

SP - S353-S358

JO - Indian Heart Journal

JF - Indian Heart Journal

SN - 0019-4832

ER -