Massive cranial osteolysis, skin changes, growth retardation and developmental delay: Gorham syndrome with systemic manifestations?

K. M. Girisha, H. K. Ganesh, Lakshmi Rao, P. S. Srilatha

Research output: Contribution to journalArticle

8 Citations (Scopus)


We report on a 16-month-old girl with multiple swellings on her skull due to massive osteolysis, growth retardation, facial anomalies, and wrinkly skin with mosaic hypopigmentation. She also had severe hypercalcemia, which gradually returned to normal levels. The condition likely represents Gorham syndrome with systemic manifestations.

Original languageEnglish
Pages (from-to)759-763
Number of pages5
JournalAmerican Journal of Medical Genetics, Part A
Issue number3
Publication statusPublished - 03-2010


All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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