Mast cell stabilizing effects of Sphaeranthus indicus

J.E. Mathew, K.K. Srinivasan, V. Dinakaran, A. Joseph

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aim of the study: We investigated the effects of Sphaeranthus indicus on mast cell stabilizing activity to provide scientific basis for the clinical use of S. indicus. Materials and methods: The protective effect of different extracts of whole plant of S. indicus against compound 48/80 and sheep serum induced mast cell degranulation was evaluated. Results: Ethanol extract of S. indicus at the doses of 150 mg/kg and 300 mg/kg and ethyl acetate extract at the dose of 100 mg/kg, 150 mg/kg and 300 mg/kg showed slightly better protection of mast cell degranulation (77-86%) than the standard drug ketotifen (75%) in the sheep serum model. These extracts also showed better mast cell stabilizing activity (77-88%) than the standard drug (69%) when peritoneal mast cells are treated with compound 48/80. Conclusion: These results suggest that S. indicus has potent mast cell stabilizing effects thereby inhibiting mediator release from mast cells. © 2009 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)394-396
Number of pages3
JournalJournal of Ethnopharmacology
Volume122
Issue number2
DOIs
Publication statusPublished - 2009

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Asteraceae
Mast Cells
p-Methoxy-N-methylphenethylamine
Cell Degranulation
Sheep
Ketotifen
Plant Extracts
Serum
Ireland
Pharmaceutical Preparations
Ethanol

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Mathew, J.E. ; Srinivasan, K.K. ; Dinakaran, V. ; Joseph, A. / Mast cell stabilizing effects of Sphaeranthus indicus. In: Journal of Ethnopharmacology. 2009 ; Vol. 122, No. 2. pp. 394-396.
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title = "Mast cell stabilizing effects of Sphaeranthus indicus",
abstract = "Aim of the study: We investigated the effects of Sphaeranthus indicus on mast cell stabilizing activity to provide scientific basis for the clinical use of S. indicus. Materials and methods: The protective effect of different extracts of whole plant of S. indicus against compound 48/80 and sheep serum induced mast cell degranulation was evaluated. Results: Ethanol extract of S. indicus at the doses of 150 mg/kg and 300 mg/kg and ethyl acetate extract at the dose of 100 mg/kg, 150 mg/kg and 300 mg/kg showed slightly better protection of mast cell degranulation (77-86{\%}) than the standard drug ketotifen (75{\%}) in the sheep serum model. These extracts also showed better mast cell stabilizing activity (77-88{\%}) than the standard drug (69{\%}) when peritoneal mast cells are treated with compound 48/80. Conclusion: These results suggest that S. indicus has potent mast cell stabilizing effects thereby inhibiting mediator release from mast cells. {\circledC} 2009 Elsevier Ireland Ltd. All rights reserved.",
author = "J.E. Mathew and K.K. Srinivasan and V. Dinakaran and A. Joseph",
note = "Cited By :15 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Mathew, J.E.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal, 576 104 Karnataka, India; email: jessyjamesmathew@yahoo.co.in Chemicals/CAS: acetic acid ethyl ester, 141-78-6; alcohol, 64-17-5; ketotifen fumarate, 34580-14-8; Plant Extracts; p-Methoxy-N-methylphenethylamine, 4091-50-3 References: Basu, N.K., Lamsal, P.P., Chemical investigation of Sphaeranthus indicus Linn (1946) Journal of American Pharmaceutical Association, 35, pp. 274-275; Bellanti, J.A., (1971) Mechanism of tissue injury produced by immunologic reactions. Immunology In: Asian ed., , W.B. Saunders Co, Tokyo pp. 184; Chadha, Y.R., (1976) The Wealth of India. The Publications and Information Directorate, , CSIR, New Delhi pp. 4-5; Farzana, S., Rubeena, S., Ahmeda, M., Healing potential of cream containing extract of Sphaeranthus indicus on dermal wounds in Guinea pigs (2006) Journal of Thnopharmacology, 107, pp. 161-163; Ghosh, M.N., (1984) Toxicity studies In: Fundamentals of Experimental Pharmacology, , Scientific Book Agency, Calcutta pp. 153-158; Gogate, M.G., Ananthasubramanian, L., Nargund, K.S., Bhattacharyya, S.C., Some interesting sesquiterpinoids from Sphaeranthus indicus Linn. (Compositae) (1986) Indian Journal of Chemistry, 25 B, pp. 233-238; Gupta, R.K., Chandra, S., Mahandevan, V., Chemical composition of Sphaeranthus indicus Linn. (1967) Indian Journal of Pharmacology, 29, pp. 47-48; Heinrich, M., Robles, M., West, J.E., Montellano, B.R.O., Rodriguez, E., Ethno pharmacology of Mexican Asteraceae (Compositae) (1998) Annual Review of Pharmacology and Toxicology, 38, pp. 539-565; Jayant, S., Sohoni, S.R., Mandakini, M., A new eudesmenolide and 2-hydroxycostic acid from Sphaeranthus indicus. X-ray molecular structure of 4α,5α-epoxy-7α-hydroxyeudesmanolide (2000) Fitoterapia, 71, pp. 264-268; Karnick, C., Kulkarni, M., Clinical evaluation of ayurvedic drugs on vitiligo (leucoderma) (1990) Maharashtra Medical Journal, 37, pp. 131-133; Kirtikar, K.R., Basu, B.D., (1918) Indian Medicinal Plants, , Lalit Mohan Basu, Allahabad, India pp. 1-2; Lee, Y.M., Kim, S.H., Shin, T.Y., Ki, H.M., Anti anaphylactic activity of Poncirus trifoliate fruit extract (1990) Journal of Ethnopharmacology, 54, pp. 77-84; Loeffler, L.J., Lovenberg, W., Sjoerdsma, A., Effects of dibutyryl-1-3,5-cyclic adenosine monophosphate, phosphodiestarases inhibitors and prostaglandin E1 on compound 48/80 induced histamine release from rat peritoneal mast cells in vitro (1971) Biochemical Pharmacology, 20, pp. 2278-2297; Nadkarni, K.M., (1976) Indian material Medica, vol. 1, , Popular Prekshan, Bombay pp. 1162; Nanda, T., Hatsutori, Y., Shimomura, K., Nakamura, masami (Mikimoto Seiyaku Kk; Nanda Tsuneo). 1995. Jpn Kokai Tokkvo koho JP07.138. 180 (95, 138, 180). Chemical Abstract 123, 92919r; Naqvi, B.S., Hashmi, K., Sheikh, D., Mahdi, A., Antibacterial activity in fruits and vegetables (1998) Pakistan Journal of Pharmacology, 15, pp. 7-11; Noguchi, K., Matsuo, K., Ohata, N., Synthesis of peptide related to immunoglobulin E (Ig E) and the examination of their pharmacological activity (1990) Chemical and Pharmaceutical Bulletin, 38, p. 2463; Prussin, C., Metcalfe, D.D., IgE, mast cells, basophils, and eosinophils (2003) Journal of Allergy and Clinical Immunology, 111, pp. 486-494; Said, H.M., (1956) Medicinal Herbal. A Textbook for Medical Students and Doctors A Research Publication, 1. , Madinat Al-Hikmah, Bait Al-Hikmah pp. 239-241; Shekhani, M.S., Shah, P.M., Yasmin, A., Siddiqui, R., Perveen, S., Khan, K.M., Kazmi, S.U., Rahman, A., An immunostimulant sesquiterpene glycolside from Sphaeranthus indicus (1990) Phytochemistry, 29, pp. 2573-2576; Varier, P.S., (1994) Indian Medicinal Plants Compendium of 500 Species, 2. , Longmann Ltd., Hyderabad pp. 200-202; Yadav, R.N., Kumar, S., (1998) A novel isoflavone glycoside from the leaves of Sphaeranthus indicus Fitoterapia, 70, pp. 127-129; Yurt, R.W., Leid, R.W., Austen, K.R., Native heparin from rat peritoneal mast cells (1977) Journal of Biological Chemistry, 252, pp. 518-521",
year = "2009",
doi = "10.1016/j.jep.2009.01.015",
language = "English",
volume = "122",
pages = "394--396",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
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Mast cell stabilizing effects of Sphaeranthus indicus. / Mathew, J.E.; Srinivasan, K.K.; Dinakaran, V.; Joseph, A.

In: Journal of Ethnopharmacology, Vol. 122, No. 2, 2009, p. 394-396.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mast cell stabilizing effects of Sphaeranthus indicus

AU - Mathew, J.E.

AU - Srinivasan, K.K.

AU - Dinakaran, V.

AU - Joseph, A.

N1 - Cited By :15 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Mathew, J.E.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal, 576 104 Karnataka, India; email: jessyjamesmathew@yahoo.co.in Chemicals/CAS: acetic acid ethyl ester, 141-78-6; alcohol, 64-17-5; ketotifen fumarate, 34580-14-8; Plant Extracts; p-Methoxy-N-methylphenethylamine, 4091-50-3 References: Basu, N.K., Lamsal, P.P., Chemical investigation of Sphaeranthus indicus Linn (1946) Journal of American Pharmaceutical Association, 35, pp. 274-275; Bellanti, J.A., (1971) Mechanism of tissue injury produced by immunologic reactions. Immunology In: Asian ed., , W.B. Saunders Co, Tokyo pp. 184; Chadha, Y.R., (1976) The Wealth of India. The Publications and Information Directorate, , CSIR, New Delhi pp. 4-5; Farzana, S., Rubeena, S., Ahmeda, M., Healing potential of cream containing extract of Sphaeranthus indicus on dermal wounds in Guinea pigs (2006) Journal of Thnopharmacology, 107, pp. 161-163; Ghosh, M.N., (1984) Toxicity studies In: Fundamentals of Experimental Pharmacology, , Scientific Book Agency, Calcutta pp. 153-158; Gogate, M.G., Ananthasubramanian, L., Nargund, K.S., Bhattacharyya, S.C., Some interesting sesquiterpinoids from Sphaeranthus indicus Linn. (Compositae) (1986) Indian Journal of Chemistry, 25 B, pp. 233-238; Gupta, R.K., Chandra, S., Mahandevan, V., Chemical composition of Sphaeranthus indicus Linn. (1967) Indian Journal of Pharmacology, 29, pp. 47-48; Heinrich, M., Robles, M., West, J.E., Montellano, B.R.O., Rodriguez, E., Ethno pharmacology of Mexican Asteraceae (Compositae) (1998) Annual Review of Pharmacology and Toxicology, 38, pp. 539-565; Jayant, S., Sohoni, S.R., Mandakini, M., A new eudesmenolide and 2-hydroxycostic acid from Sphaeranthus indicus. X-ray molecular structure of 4α,5α-epoxy-7α-hydroxyeudesmanolide (2000) Fitoterapia, 71, pp. 264-268; Karnick, C., Kulkarni, M., Clinical evaluation of ayurvedic drugs on vitiligo (leucoderma) (1990) Maharashtra Medical Journal, 37, pp. 131-133; Kirtikar, K.R., Basu, B.D., (1918) Indian Medicinal Plants, , Lalit Mohan Basu, Allahabad, India pp. 1-2; Lee, Y.M., Kim, S.H., Shin, T.Y., Ki, H.M., Anti anaphylactic activity of Poncirus trifoliate fruit extract (1990) Journal of Ethnopharmacology, 54, pp. 77-84; Loeffler, L.J., Lovenberg, W., Sjoerdsma, A., Effects of dibutyryl-1-3,5-cyclic adenosine monophosphate, phosphodiestarases inhibitors and prostaglandin E1 on compound 48/80 induced histamine release from rat peritoneal mast cells in vitro (1971) Biochemical Pharmacology, 20, pp. 2278-2297; Nadkarni, K.M., (1976) Indian material Medica, vol. 1, , Popular Prekshan, Bombay pp. 1162; Nanda, T., Hatsutori, Y., Shimomura, K., Nakamura, masami (Mikimoto Seiyaku Kk; Nanda Tsuneo). 1995. Jpn Kokai Tokkvo koho JP07.138. 180 (95, 138, 180). Chemical Abstract 123, 92919r; Naqvi, B.S., Hashmi, K., Sheikh, D., Mahdi, A., Antibacterial activity in fruits and vegetables (1998) Pakistan Journal of Pharmacology, 15, pp. 7-11; Noguchi, K., Matsuo, K., Ohata, N., Synthesis of peptide related to immunoglobulin E (Ig E) and the examination of their pharmacological activity (1990) Chemical and Pharmaceutical Bulletin, 38, p. 2463; Prussin, C., Metcalfe, D.D., IgE, mast cells, basophils, and eosinophils (2003) Journal of Allergy and Clinical Immunology, 111, pp. 486-494; Said, H.M., (1956) Medicinal Herbal. A Textbook for Medical Students and Doctors A Research Publication, 1. , Madinat Al-Hikmah, Bait Al-Hikmah pp. 239-241; Shekhani, M.S., Shah, P.M., Yasmin, A., Siddiqui, R., Perveen, S., Khan, K.M., Kazmi, S.U., Rahman, A., An immunostimulant sesquiterpene glycolside from Sphaeranthus indicus (1990) Phytochemistry, 29, pp. 2573-2576; Varier, P.S., (1994) Indian Medicinal Plants Compendium of 500 Species, 2. , Longmann Ltd., Hyderabad pp. 200-202; Yadav, R.N., Kumar, S., (1998) A novel isoflavone glycoside from the leaves of Sphaeranthus indicus Fitoterapia, 70, pp. 127-129; Yurt, R.W., Leid, R.W., Austen, K.R., Native heparin from rat peritoneal mast cells (1977) Journal of Biological Chemistry, 252, pp. 518-521

PY - 2009

Y1 - 2009

N2 - Aim of the study: We investigated the effects of Sphaeranthus indicus on mast cell stabilizing activity to provide scientific basis for the clinical use of S. indicus. Materials and methods: The protective effect of different extracts of whole plant of S. indicus against compound 48/80 and sheep serum induced mast cell degranulation was evaluated. Results: Ethanol extract of S. indicus at the doses of 150 mg/kg and 300 mg/kg and ethyl acetate extract at the dose of 100 mg/kg, 150 mg/kg and 300 mg/kg showed slightly better protection of mast cell degranulation (77-86%) than the standard drug ketotifen (75%) in the sheep serum model. These extracts also showed better mast cell stabilizing activity (77-88%) than the standard drug (69%) when peritoneal mast cells are treated with compound 48/80. Conclusion: These results suggest that S. indicus has potent mast cell stabilizing effects thereby inhibiting mediator release from mast cells. © 2009 Elsevier Ireland Ltd. All rights reserved.

AB - Aim of the study: We investigated the effects of Sphaeranthus indicus on mast cell stabilizing activity to provide scientific basis for the clinical use of S. indicus. Materials and methods: The protective effect of different extracts of whole plant of S. indicus against compound 48/80 and sheep serum induced mast cell degranulation was evaluated. Results: Ethanol extract of S. indicus at the doses of 150 mg/kg and 300 mg/kg and ethyl acetate extract at the dose of 100 mg/kg, 150 mg/kg and 300 mg/kg showed slightly better protection of mast cell degranulation (77-86%) than the standard drug ketotifen (75%) in the sheep serum model. These extracts also showed better mast cell stabilizing activity (77-88%) than the standard drug (69%) when peritoneal mast cells are treated with compound 48/80. Conclusion: These results suggest that S. indicus has potent mast cell stabilizing effects thereby inhibiting mediator release from mast cells. © 2009 Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.jep.2009.01.015

DO - 10.1016/j.jep.2009.01.015

M3 - Article

VL - 122

SP - 394

EP - 396

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 2

ER -