Mast cell variation in some commonly encountered lesions of salivary glands

V. Seema, V. L. Pattankar

Research output: Contribution to journalArticlepeer-review


Mast cells with a battery of crucial chemical mediators in their typical metachromatic granules are known to play a role in health and various disease states in man. This study was undertaken'to evaluate the mast cell profile in some commonly encountered salivary gland lesions.The present study was carried out in the Department of Pathology, M.R. Medical College, Gulbarga after the institutional ethical clearance. The study included a total of 50 cases in each group. Sections were stained with H&E and 1% aqueous toluidine blue (pH=4) for mast cells. The mast cell count was performed per 10 HPF, tabulated, analyzed for statistical significance using students't' test. A significant (p<0.001) increase of mast cell was observed in commonly encountered lesions of salivary gland when compared with that of control group. Mast cell count was significantly increased in Pleomorphic adenoma as compared to basal cell adenoma and oncocytoma. The present study documents striking alteration in mast cell in some common salivary gland lesions. Mast cell profile may be used as an additional diagnostic or supportive parameter to differentiate between various benign lesions of salivary gland in addition to other diagnostic parameters.

Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Issue number2
Publication statusPublished - 01-04-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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