Maternal and fetal indicators of oxidative stress in various obstetric complications

Guruprasad Rao, Ullas Kamath, Chaerkadi Raghothama, K. Sujatha Pradeep, Pragna Rao

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The present study demonstrates the incidence of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity in different complications of pregnancy. In fetuses born after premature rupture of membranes, lipid peroxidation was significantly elevated as indicated by increased malondialdehyde levels (p<0.05) as compared to controls. Proteolytic activity in the erythrocytes of mothers in this group was also significantly high (p<0.01). In patients delivered by lower segment cesarian section, lipid peroxidation and proteolytic activity in maternal erythrocytes were significantly high (p<0.05 and p<0.001 respectively). In patients with prolonged second stage of labour, lipid peroxidation and proteolytic activity in maternal erythrocytes was significantly higher than in controls (p<0.001 and p<0.05 respectively). In this group, endogenous protein damage due to oxidative stress was significantly high both in the mother and the fetus (p<0.001 and p<0.05 respectively).

Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalIndian Journal of Clinical Biochemistry
Volume18
Issue number2
Publication statusPublished - 07-2003

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Obstetrics
Oxidative stress
Oxidative Stress
Lipid Peroxidation
Mothers
Lipids
Erythrocytes
Membrane Lipids
Malondialdehyde
Fetus
Reactive Oxygen Species
Second Labor Stage
Proteins
Personnel
Pregnancy Complications
Oxidation
Cesarean Section
Rupture
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

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Maternal and fetal indicators of oxidative stress in various obstetric complications. / Rao, Guruprasad; Kamath, Ullas; Raghothama, Chaerkadi; Pradeep, K. Sujatha; Rao, Pragna.

In: Indian Journal of Clinical Biochemistry, Vol. 18, No. 2, 07.2003, p. 80-86.

Research output: Contribution to journalArticle

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AU - Rao, Guruprasad

AU - Kamath, Ullas

AU - Raghothama, Chaerkadi

AU - Pradeep, K. Sujatha

AU - Rao, Pragna

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AB - The present study demonstrates the incidence of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity in different complications of pregnancy. In fetuses born after premature rupture of membranes, lipid peroxidation was significantly elevated as indicated by increased malondialdehyde levels (p<0.05) as compared to controls. Proteolytic activity in the erythrocytes of mothers in this group was also significantly high (p<0.01). In patients delivered by lower segment cesarian section, lipid peroxidation and proteolytic activity in maternal erythrocytes were significantly high (p<0.05 and p<0.001 respectively). In patients with prolonged second stage of labour, lipid peroxidation and proteolytic activity in maternal erythrocytes was significantly higher than in controls (p<0.001 and p<0.05 respectively). In this group, endogenous protein damage due to oxidative stress was significantly high both in the mother and the fetus (p<0.001 and p<0.05 respectively).

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