Maternal serum lipid levels, oxidative stress and antioxidant activity in pre-eclampsia patients from Southwest India

Parvati V. Bhat, Vinutha Vinod, Alluri Naga Priyanka, Asha Kamath

Research output: Contribution to journalArticle

Abstract

Objective: A study was carried out to evaluate the effects of metabolic syndrome components and oxidative stress factors among preeclamptic women from South West India. Study design: A case-control study was carried out by enrolling fifty pre-eclampsia cases and hundred low-risk pregnant women within the age group of 18–40 years, at 28–34 weeks of pregnancy. The fasting glucose level, fasting insulin level, insulin resistance, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), malondialdehyde, the ferric reducing ability of plasma (FRAP assay), cardiac output and aortic wall distensibility were measured. Main outcome measures: There was a significant rise in the fasting blood glucose, fasting insulin, insulin resistance levels, total cholesterol, triglycerides, LDL, and antioxidant levels in pre-eclamptic women (p < 0.001). The cardiac output and aortic wall distensibility were observed to be low in the cases. Conclusion: We conclude that abnormal lipid metabolism and high lipid peroxide concentrations observed in pre-eclampsia may result in oxidative stress and vascular dysfunction.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalPregnancy Hypertension
Volume15
DOIs
Publication statusPublished - 01-01-2019

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Pre-Eclampsia
India
Fasting
Oxidative Stress
Antioxidants
Mothers
Lipids
Serum
Cardiac Output
Insulin Resistance
Insulin
Aptitude
Lipid Peroxides
Malondialdehyde
LDL Lipoproteins
Lipid Metabolism
LDL Cholesterol
HDL Cholesterol
Blood Vessels
Blood Glucose

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Obstetrics and Gynaecology

Cite this

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Maternal serum lipid levels, oxidative stress and antioxidant activity in pre-eclampsia patients from Southwest India. / Bhat, Parvati V.; Vinod, Vinutha; Priyanka, Alluri Naga; Kamath, Asha.

In: Pregnancy Hypertension, Vol. 15, 01.01.2019, p. 130-133.

Research output: Contribution to journalArticle

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