Meal induced dyslipidemia in type 2 diabetes mellitus

Research output: Contribution to journalArticle

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Abstract

Introduction: Diabetes is a common metabolic disorder often associated with dyslipidemia. There is altered response in postprandial lipoprotein metabolism which is found to be associated with cardiovascular disease. Aim: Hence fasting and post meal lipids were analysed in controlled and poorly controlled diabetes mellitus. Materials and methods: Total 60 type 2 diabetic patients on oral hypoglycemic (duration 5-15 years) were enrolled into the study. They were divided based on HbA1c values as Group1 (7.5%) and Group2 (7.6%). Plasma glucose and serum lipid parameters both in fasting (F) and 2 hrs post meal (PP) were assayed. Results: Fasting and 2 hours postmeal plasma glucose values were in accordance with HbA1c values. Significant increase in PP TG(p<0.001) and decrease in PP LDL-C(p<0.001) were found in both the groups. TC, HDL-C and TC/HDL-C ratio in fasting and PP state was comparable in both the groups. Conclusion: Among diabetic subjects there is a post meal dysmetabolism of lipids in the form of raised TG and low LDL-C which was not augmented by poor glycaemia.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalBiomedicine (India)
Volume34
Issue number1
Publication statusPublished - 01-01-2014

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Medical problems
Dyslipidemias
Type 2 Diabetes Mellitus
Meals
Fasting
Lipids
Plasmas
Glucose
Hypoglycemic Agents
Metabolism
Lipoproteins
Diabetes Mellitus
Cardiovascular Diseases
Serum
oxidized low density lipoprotein

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Meal induced dyslipidemia in type 2 diabetes mellitus",
abstract = "Introduction: Diabetes is a common metabolic disorder often associated with dyslipidemia. There is altered response in postprandial lipoprotein metabolism which is found to be associated with cardiovascular disease. Aim: Hence fasting and post meal lipids were analysed in controlled and poorly controlled diabetes mellitus. Materials and methods: Total 60 type 2 diabetic patients on oral hypoglycemic (duration 5-15 years) were enrolled into the study. They were divided based on HbA1c values as Group1 (7.5{\%}) and Group2 (7.6{\%}). Plasma glucose and serum lipid parameters both in fasting (F) and 2 hrs post meal (PP) were assayed. Results: Fasting and 2 hours postmeal plasma glucose values were in accordance with HbA1c values. Significant increase in PP TG(p<0.001) and decrease in PP LDL-C(p<0.001) were found in both the groups. TC, HDL-C and TC/HDL-C ratio in fasting and PP state was comparable in both the groups. Conclusion: Among diabetic subjects there is a post meal dysmetabolism of lipids in the form of raised TG and low LDL-C which was not augmented by poor glycaemia.",
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Meal induced dyslipidemia in type 2 diabetes mellitus. / Sulekha, S.; Manjrekar, Poornima A.; Hegde, A.; Shenoy, R.

In: Biomedicine (India), Vol. 34, No. 1, 01.01.2014, p. 137-141.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Meal induced dyslipidemia in type 2 diabetes mellitus

AU - Sulekha, S.

AU - Manjrekar, Poornima A.

AU - Hegde, A.

AU - Shenoy, R.

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N2 - Introduction: Diabetes is a common metabolic disorder often associated with dyslipidemia. There is altered response in postprandial lipoprotein metabolism which is found to be associated with cardiovascular disease. Aim: Hence fasting and post meal lipids were analysed in controlled and poorly controlled diabetes mellitus. Materials and methods: Total 60 type 2 diabetic patients on oral hypoglycemic (duration 5-15 years) were enrolled into the study. They were divided based on HbA1c values as Group1 (7.5%) and Group2 (7.6%). Plasma glucose and serum lipid parameters both in fasting (F) and 2 hrs post meal (PP) were assayed. Results: Fasting and 2 hours postmeal plasma glucose values were in accordance with HbA1c values. Significant increase in PP TG(p<0.001) and decrease in PP LDL-C(p<0.001) were found in both the groups. TC, HDL-C and TC/HDL-C ratio in fasting and PP state was comparable in both the groups. Conclusion: Among diabetic subjects there is a post meal dysmetabolism of lipids in the form of raised TG and low LDL-C which was not augmented by poor glycaemia.

AB - Introduction: Diabetes is a common metabolic disorder often associated with dyslipidemia. There is altered response in postprandial lipoprotein metabolism which is found to be associated with cardiovascular disease. Aim: Hence fasting and post meal lipids were analysed in controlled and poorly controlled diabetes mellitus. Materials and methods: Total 60 type 2 diabetic patients on oral hypoglycemic (duration 5-15 years) were enrolled into the study. They were divided based on HbA1c values as Group1 (7.5%) and Group2 (7.6%). Plasma glucose and serum lipid parameters both in fasting (F) and 2 hrs post meal (PP) were assayed. Results: Fasting and 2 hours postmeal plasma glucose values were in accordance with HbA1c values. Significant increase in PP TG(p<0.001) and decrease in PP LDL-C(p<0.001) were found in both the groups. TC, HDL-C and TC/HDL-C ratio in fasting and PP state was comparable in both the groups. Conclusion: Among diabetic subjects there is a post meal dysmetabolism of lipids in the form of raised TG and low LDL-C which was not augmented by poor glycaemia.

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