Mechanistic study of oxidation of sulfacetamide by diperiodatocuprate(III) in aqueous alkaline medium

P. N. Naik, S. D. Kulkarni, S. A. Chimatadar, S. T. Nandibewoor

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The oxidation of sulfacetamide, a sulfonamide drug, by alkaline diperiodatocuprate(III) has been studied at 298 K and at constant ionic strength. The reaction is first order in diperiodatocuprate(III) and has less than unit order in sulfacetamide concentration. The rate constants increase with increase in alkali concentration and decrease with increase in periodate concentration. A mechanism has been proposed wherein monoperiodatocuprate(III) is the active species. The reaction constants involved in the different steps of the mechanism and the activation parameters for the slow step have been computed.

Original languageEnglish
Pages (from-to)1666-1670
Number of pages5
JournalIndian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry
Volume47
Issue number11
Publication statusPublished - 01-11-2008

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Sulfacetamide
Rate constants
Oxidation
oxidation
Sulfonamides
Alkalies
Ionic strength
Chemical activation
alkalies
drugs
activation
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

Cite this

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abstract = "The oxidation of sulfacetamide, a sulfonamide drug, by alkaline diperiodatocuprate(III) has been studied at 298 K and at constant ionic strength. The reaction is first order in diperiodatocuprate(III) and has less than unit order in sulfacetamide concentration. The rate constants increase with increase in alkali concentration and decrease with increase in periodate concentration. A mechanism has been proposed wherein monoperiodatocuprate(III) is the active species. The reaction constants involved in the different steps of the mechanism and the activation parameters for the slow step have been computed.",
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Mechanistic study of oxidation of sulfacetamide by diperiodatocuprate(III) in aqueous alkaline medium. / Naik, P. N.; Kulkarni, S. D.; Chimatadar, S. A.; Nandibewoor, S. T.

In: Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, Vol. 47, No. 11, 01.11.2008, p. 1666-1670.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mechanistic study of oxidation of sulfacetamide by diperiodatocuprate(III) in aqueous alkaline medium

AU - Naik, P. N.

AU - Kulkarni, S. D.

AU - Chimatadar, S. A.

AU - Nandibewoor, S. T.

PY - 2008/11/1

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