Medical interventions for chronic rhinosinusitis in cystic fibrosis

Tulasi Kota Karanth, Veena Kota Laxminarayan KL Karanth, Bryan K. Ward, Bradford A. Woodworth, Laxminarayan Karanth

Research output: Contribution to journalReview article

Abstract

Background Chronic rhinosinusitis frequently occurs in people with cystic fibrosis. Several medical interventions are available for treating chronic rhinosinusitis in people with cystic fibrosis; for example, different concentrations of nasal saline irrigations, topical or oral corticosteroids, antibiotics-including nebulized antibiotics, dornase alfa and modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) (such as lumacaftor, ivacaftor or tezacaftor). However, the efficacy of these interventions is unclear. Objectives The objective of this review is to compare the effects of different medical interventions in people diagnosed with cystic fibrosis and chronic rhinosinusitis. Search methods We searched the Cochrane Cystic Fibrosis Trials Register, compiled from electronic database searches and hand searching of journals and conference abstract books. Date of last search of trials register: 22 May 2019. We also searched ongoing trials databases, other medical databases and the reference lists of relevant articles and reviews. Date of latest additional searches: 20 May 2019. Selection criteria Randomized and quasi-randomized trials of different medical interventions compared to each other or to no intervention or to placebo. Data collection and analysis Two review authors independently assessed trials identified for potential inclusion in the review. We planned to conduct data collection and analysis in accordance with Cochrane methods and to independently rate the quality of the evidence for each outcome using the GRADE guidelines. Main results We identified no trials that met the pre-defined inclusion criteria. The searches identified 47 trials, none of which were eligible for inclusion in the current version of this review.

Original languageEnglish
Article numberCD012979
JournalCochrane Database of Systematic Reviews
Volume2019
Issue number10
DOIs
Publication statusPublished - 23-10-2019

Fingerprint

Cystic Fibrosis
Databases
Nasal Lavage
Anti-Bacterial Agents
Cystic Fibrosis Transmembrane Conductance Regulator
Patient Selection
Adrenal Cortex Hormones
Placebos
Guidelines

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Karanth, T. K., Karanth, V. K. L. KL., Ward, B. K., Woodworth, B. A., & Karanth, L. (2019). Medical interventions for chronic rhinosinusitis in cystic fibrosis. Cochrane Database of Systematic Reviews, 2019(10), [CD012979]. https://doi.org/10.1002/14651858.CD012979.pub2
Karanth, Tulasi Kota ; Karanth, Veena Kota Laxminarayan KL ; Ward, Bryan K. ; Woodworth, Bradford A. ; Karanth, Laxminarayan. / Medical interventions for chronic rhinosinusitis in cystic fibrosis. In: Cochrane Database of Systematic Reviews. 2019 ; Vol. 2019, No. 10.
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Karanth, TK, Karanth, VKLKL, Ward, BK, Woodworth, BA & Karanth, L 2019, 'Medical interventions for chronic rhinosinusitis in cystic fibrosis', Cochrane Database of Systematic Reviews, vol. 2019, no. 10, CD012979. https://doi.org/10.1002/14651858.CD012979.pub2

Medical interventions for chronic rhinosinusitis in cystic fibrosis. / Karanth, Tulasi Kota; Karanth, Veena Kota Laxminarayan KL; Ward, Bryan K.; Woodworth, Bradford A.; Karanth, Laxminarayan.

In: Cochrane Database of Systematic Reviews, Vol. 2019, No. 10, CD012979, 23.10.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Medical interventions for chronic rhinosinusitis in cystic fibrosis

AU - Karanth, Tulasi Kota

AU - Karanth, Veena Kota Laxminarayan KL

AU - Ward, Bryan K.

AU - Woodworth, Bradford A.

AU - Karanth, Laxminarayan

PY - 2019/10/23

Y1 - 2019/10/23

N2 - Background Chronic rhinosinusitis frequently occurs in people with cystic fibrosis. Several medical interventions are available for treating chronic rhinosinusitis in people with cystic fibrosis; for example, different concentrations of nasal saline irrigations, topical or oral corticosteroids, antibiotics-including nebulized antibiotics, dornase alfa and modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) (such as lumacaftor, ivacaftor or tezacaftor). However, the efficacy of these interventions is unclear. Objectives The objective of this review is to compare the effects of different medical interventions in people diagnosed with cystic fibrosis and chronic rhinosinusitis. Search methods We searched the Cochrane Cystic Fibrosis Trials Register, compiled from electronic database searches and hand searching of journals and conference abstract books. Date of last search of trials register: 22 May 2019. We also searched ongoing trials databases, other medical databases and the reference lists of relevant articles and reviews. Date of latest additional searches: 20 May 2019. Selection criteria Randomized and quasi-randomized trials of different medical interventions compared to each other or to no intervention or to placebo. Data collection and analysis Two review authors independently assessed trials identified for potential inclusion in the review. We planned to conduct data collection and analysis in accordance with Cochrane methods and to independently rate the quality of the evidence for each outcome using the GRADE guidelines. Main results We identified no trials that met the pre-defined inclusion criteria. The searches identified 47 trials, none of which were eligible for inclusion in the current version of this review.

AB - Background Chronic rhinosinusitis frequently occurs in people with cystic fibrosis. Several medical interventions are available for treating chronic rhinosinusitis in people with cystic fibrosis; for example, different concentrations of nasal saline irrigations, topical or oral corticosteroids, antibiotics-including nebulized antibiotics, dornase alfa and modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) (such as lumacaftor, ivacaftor or tezacaftor). However, the efficacy of these interventions is unclear. Objectives The objective of this review is to compare the effects of different medical interventions in people diagnosed with cystic fibrosis and chronic rhinosinusitis. Search methods We searched the Cochrane Cystic Fibrosis Trials Register, compiled from electronic database searches and hand searching of journals and conference abstract books. Date of last search of trials register: 22 May 2019. We also searched ongoing trials databases, other medical databases and the reference lists of relevant articles and reviews. Date of latest additional searches: 20 May 2019. Selection criteria Randomized and quasi-randomized trials of different medical interventions compared to each other or to no intervention or to placebo. Data collection and analysis Two review authors independently assessed trials identified for potential inclusion in the review. We planned to conduct data collection and analysis in accordance with Cochrane methods and to independently rate the quality of the evidence for each outcome using the GRADE guidelines. Main results We identified no trials that met the pre-defined inclusion criteria. The searches identified 47 trials, none of which were eligible for inclusion in the current version of this review.

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U2 - 10.1002/14651858.CD012979.pub2

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