Melioidosis: An under-diagnosed entity in western coastal India: A clinico-microbiological analysis

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Abstract

Clinico-microbiological analysis of a series of 25 patients with culture proven melioidosis was done. All patients came from the coastal regions of Kerala and Karnataka and presented between June 2005 to July 2006. They were analysed with respect to clinical presentation, occupation, epidemiology and microbiological features. No single presenting clinical feature was found to be typical of melioidosis. The disease was found to mimic a variety of conditions, including tuberculosis and malignancy. Burkholderia pseudomallei was isolated from blood, sputum, pus, urine, synovial, peritoneal and pericardial fluids. Diabetes mellitus was the most common predisposing factor and 80% of the cases presented during the Southwest monsoon (June to September). It is probable that melioidosis is highly prevalent in western coastal India and yet, greatly underestimated. Better awareness, both among clinicians and microbiologists, coupled with improved diagnostic methods to allow early diagnosis and hence early treatment, will significantly reduce the morbidity and mortality associated with this disease.

Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalIndian Journal of Medical Microbiology
Volume25
Issue number3
Publication statusPublished - 01-07-2007

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Melioidosis
India
Burkholderia pseudomallei
Suppuration
Ascitic Fluid
Synovial Fluid
Sputum
Occupations
Causality
Early Diagnosis
Diabetes Mellitus
Epidemiology
Tuberculosis
Urine
Morbidity
Mortality
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

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abstract = "Clinico-microbiological analysis of a series of 25 patients with culture proven melioidosis was done. All patients came from the coastal regions of Kerala and Karnataka and presented between June 2005 to July 2006. They were analysed with respect to clinical presentation, occupation, epidemiology and microbiological features. No single presenting clinical feature was found to be typical of melioidosis. The disease was found to mimic a variety of conditions, including tuberculosis and malignancy. Burkholderia pseudomallei was isolated from blood, sputum, pus, urine, synovial, peritoneal and pericardial fluids. Diabetes mellitus was the most common predisposing factor and 80{\%} of the cases presented during the Southwest monsoon (June to September). It is probable that melioidosis is highly prevalent in western coastal India and yet, greatly underestimated. Better awareness, both among clinicians and microbiologists, coupled with improved diagnostic methods to allow early diagnosis and hence early treatment, will significantly reduce the morbidity and mortality associated with this disease.",
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AU - Shrikala, B.

AU - Bharathi, B.

AU - Suchitra, U.

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