Melioidosis in southern India: Epidemiological and clinical profile

K. Saravu, C. Mukhopadhyay, S. Vishwanath, R. Valsalan, M. Docherla, K. E. Vandana, B. A. Shastry, I. Bairy, S. P. Rao

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Melioidosis, which is mainly prevalent in Thailand and Australia, has shown an increasing trend in India in the last few years. We carried out a retrospective study of 25 culture-proven adult cases of melioidosis who were admitted to a tertiary care hospital in southern India during June 2001 to September 2007. There was a six-fold increase in the number of cases in 2006 and 2007 as compared to 2001. Diabetes mellitus was the predisposing factor in 68% of cases, followed by alcoholism (28%). The clinical presentations were fever (80%), pneumonia and/or pleural effusion (48%), hepatomegaly (56%), joint involvement, and/or osteomyelitis (48%), splenomegaly (40%), splenic abscess (24%) and septicemia (28%). The organism, Burkholderia pseudomallei, was sensitive to co-amoxiclav, cotrimoxazole, ceftazidime, and carbapenem. The study suggests that melioidosis is an emerging infectious disease in the southwestern coastal belt of India, and it is likely to happen at much higher incidence.

Original languageEnglish
Pages (from-to)401-409
Number of pages9
JournalSoutheast Asian Journal of Tropical Medicine and Public Health
Volume41
Issue number2
Publication statusPublished - 01-03-2010

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Melioidosis
India
Burkholderia pseudomallei
Emerging Communicable Diseases
Amoxicillin-Potassium Clavulanate Combination
Carbapenems
Hepatomegaly
Ceftazidime
Splenomegaly
Sulfamethoxazole Drug Combination Trimethoprim
Osteomyelitis
Thailand
Pleural Effusion
Tertiary Healthcare
Tertiary Care Centers
Causality
Abscess
Alcoholism
Sepsis
Pneumonia

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

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Melioidosis in southern India : Epidemiological and clinical profile. / Saravu, K.; Mukhopadhyay, C.; Vishwanath, S.; Valsalan, R.; Docherla, M.; Vandana, K. E.; Shastry, B. A.; Bairy, I.; Rao, S. P.

In: Southeast Asian Journal of Tropical Medicine and Public Health, Vol. 41, No. 2, 01.03.2010, p. 401-409.

Research output: Contribution to journalArticle

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T2 - Epidemiological and clinical profile

AU - Saravu, K.

AU - Mukhopadhyay, C.

AU - Vishwanath, S.

AU - Valsalan, R.

AU - Docherla, M.

AU - Vandana, K. E.

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AU - Bairy, I.

AU - Rao, S. P.

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