Metamorphosis of Twin Screw Extruder-Based Granulation Technology: Applications Focusing on Its Impact on Conventional Granulation Technology

Rajat Radhakrishna Rao, Abhijeet Pandey, Aswathi R. Hegde, Vijay Induvadan Kulkarni, Chetan Chincholi, Vinay Rao, Indu Bhushan, Srinivas Mutalik

Research output: Contribution to journalReview articlepeer-review

Abstract

In order to be at pace with the market requirements of solid dosage forms and regulatory standards, a transformation towards systematic processing using continuous manufacturing (CM) and automated model-based control is being thought through for its fundamental advantages over conventional batch manufacturing. CM eliminates the key gaps through the integration of various processes while preserving quality attributes via the use of process analytical technology (PAT). The twin screw extruder (TSE) is one such equipment adopted by the pharmaceutical industry as a substitute for the traditional batch granulation process. Various types of granulation techniques using twin screw extrusion technology have been explored in the article. Furthermore, individual components of a TSE and their conjugation with PAT tools and the advancements and applications in the field of nutraceuticals and nanotechnology have also been discussed. Thus, the future of granulation lies on the shoulders of continuous TSE, where it can be coupled with computational mathematical studies to mitigate its complications.

Original languageEnglish
Article number24
Pages (from-to)24
JournalAAPS PharmSciTech
Volume23
Issue number1
DOIs
Publication statusPublished - 14-12-2021

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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