Metformin - A convenient alternative to insulin for Indian women with diabetes in pregnancy

Lavanya Rai, D. Meenakshi, Asha Kamath

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: To compare the use of metformin with that of insulin for the treatment of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) unresponsive to diet therapy. Materials and Methods: In this prospective observational study, maternal glycemic control and perinatal outcome in diabetic pregnancies were compared between 2 obstetric units, one using insulin therapy and the other using metformin therapy. Baseline pretreatment glycemic profile was done and then repeated weekly throughout pregnancy. The outcome measures studied were glycemic control, maternal complications and perinatal outcome. Results: Sixty women with gestational and type 2 diabetes were enrolled, 30 each for metformin and insulin. Both groups were comparable with respect to age, body mass index (BMI), parity and pretreatment plasma glucose levels. Glycemic control was better with metformin after 1 week of therapy and also throughout gestation (P = 0.03-0.007). There were no major complications or perinatal deaths in this study. Mean gestational age and birth weight (2.9 ± 0.4 kg versus 3.1 ± 0.4 kg, P = 0.30) were comparable. However, there was a significant increase in neonatal intensive care unit (NICU) admission and stay for babies born in the insulin group. The cost of treatment was tenfold higher in thethe insulin group. Conclusion: Metformin is clinically effective, cheap and a safe alternative to insulin therapy in pregnant diabetic women.

Original languageEnglish
Pages (from-to)491-497
Number of pages7
JournalIndian Journal of Medical Sciences
Volume63
Issue number11
DOIs
Publication statusPublished - 01-11-2009

Fingerprint

Pregnancy in Diabetics
Metformin
Insulin
Gestational Diabetes
Type 2 Diabetes Mellitus
Mothers
Diet Therapy
Therapeutics
Pregnancy
Neonatal Intensive Care Units
Parity
Birth Weight
Health Care Costs
Gestational Age
Obstetrics
Observational Studies
Pregnant Women
Body Mass Index
Outcome Assessment (Health Care)
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{58e4f0ba1efd4ccf8d388c86800107eb,
title = "Metformin - A convenient alternative to insulin for Indian women with diabetes in pregnancy",
abstract = "Objective: To compare the use of metformin with that of insulin for the treatment of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) unresponsive to diet therapy. Materials and Methods: In this prospective observational study, maternal glycemic control and perinatal outcome in diabetic pregnancies were compared between 2 obstetric units, one using insulin therapy and the other using metformin therapy. Baseline pretreatment glycemic profile was done and then repeated weekly throughout pregnancy. The outcome measures studied were glycemic control, maternal complications and perinatal outcome. Results: Sixty women with gestational and type 2 diabetes were enrolled, 30 each for metformin and insulin. Both groups were comparable with respect to age, body mass index (BMI), parity and pretreatment plasma glucose levels. Glycemic control was better with metformin after 1 week of therapy and also throughout gestation (P = 0.03-0.007). There were no major complications or perinatal deaths in this study. Mean gestational age and birth weight (2.9 ± 0.4 kg versus 3.1 ± 0.4 kg, P = 0.30) were comparable. However, there was a significant increase in neonatal intensive care unit (NICU) admission and stay for babies born in the insulin group. The cost of treatment was tenfold higher in thethe insulin group. Conclusion: Metformin is clinically effective, cheap and a safe alternative to insulin therapy in pregnant diabetic women.",
author = "Lavanya Rai and D. Meenakshi and Asha Kamath",
year = "2009",
month = "11",
day = "1",
doi = "10.4103/0019-5359.58878",
language = "English",
volume = "63",
pages = "491--497",
journal = "Indian Journal of Medical Sciences",
issn = "0019-5359",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "11",

}

Metformin - A convenient alternative to insulin for Indian women with diabetes in pregnancy. / Rai, Lavanya; Meenakshi, D.; Kamath, Asha.

In: Indian Journal of Medical Sciences, Vol. 63, No. 11, 01.11.2009, p. 491-497.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Metformin - A convenient alternative to insulin for Indian women with diabetes in pregnancy

AU - Rai, Lavanya

AU - Meenakshi, D.

AU - Kamath, Asha

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Objective: To compare the use of metformin with that of insulin for the treatment of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) unresponsive to diet therapy. Materials and Methods: In this prospective observational study, maternal glycemic control and perinatal outcome in diabetic pregnancies were compared between 2 obstetric units, one using insulin therapy and the other using metformin therapy. Baseline pretreatment glycemic profile was done and then repeated weekly throughout pregnancy. The outcome measures studied were glycemic control, maternal complications and perinatal outcome. Results: Sixty women with gestational and type 2 diabetes were enrolled, 30 each for metformin and insulin. Both groups were comparable with respect to age, body mass index (BMI), parity and pretreatment plasma glucose levels. Glycemic control was better with metformin after 1 week of therapy and also throughout gestation (P = 0.03-0.007). There were no major complications or perinatal deaths in this study. Mean gestational age and birth weight (2.9 ± 0.4 kg versus 3.1 ± 0.4 kg, P = 0.30) were comparable. However, there was a significant increase in neonatal intensive care unit (NICU) admission and stay for babies born in the insulin group. The cost of treatment was tenfold higher in thethe insulin group. Conclusion: Metformin is clinically effective, cheap and a safe alternative to insulin therapy in pregnant diabetic women.

AB - Objective: To compare the use of metformin with that of insulin for the treatment of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) unresponsive to diet therapy. Materials and Methods: In this prospective observational study, maternal glycemic control and perinatal outcome in diabetic pregnancies were compared between 2 obstetric units, one using insulin therapy and the other using metformin therapy. Baseline pretreatment glycemic profile was done and then repeated weekly throughout pregnancy. The outcome measures studied were glycemic control, maternal complications and perinatal outcome. Results: Sixty women with gestational and type 2 diabetes were enrolled, 30 each for metformin and insulin. Both groups were comparable with respect to age, body mass index (BMI), parity and pretreatment plasma glucose levels. Glycemic control was better with metformin after 1 week of therapy and also throughout gestation (P = 0.03-0.007). There were no major complications or perinatal deaths in this study. Mean gestational age and birth weight (2.9 ± 0.4 kg versus 3.1 ± 0.4 kg, P = 0.30) were comparable. However, there was a significant increase in neonatal intensive care unit (NICU) admission and stay for babies born in the insulin group. The cost of treatment was tenfold higher in thethe insulin group. Conclusion: Metformin is clinically effective, cheap and a safe alternative to insulin therapy in pregnant diabetic women.

UR - http://www.scopus.com/inward/record.url?scp=76549102255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76549102255&partnerID=8YFLogxK

U2 - 10.4103/0019-5359.58878

DO - 10.4103/0019-5359.58878

M3 - Article

VL - 63

SP - 491

EP - 497

JO - Indian Journal of Medical Sciences

JF - Indian Journal of Medical Sciences

SN - 0019-5359

IS - 11

ER -