Metformin attenuates cognitive deficits in experimentally induced Alzheimer's disease

Devasrita Dash, Bharti Chogtu, Laxmianarayana Bairy Kurady

Research output: Contribution to journalArticle

Abstract

A study was undertaken to evaluate the effect of metformin on learning memory in experimentally induced Alzheimer's disease in Wistar rats. A total of 30 Wistar rats were divided in to five groups of six rats each. Group 1 served as control. In Group 2,3 and 4 Alzheimer's disease was induced by administering aluminum chloride (17 mg/kg) orally to the animals for a period of 4 weeks once daily. Group 1and 2 received distilled water, group 3 received rivastigmine (0.3mg/kg) and group 4 and five received metformin 100mg/kg. All the rats were subjected to passive avoidance test. At the end of the experiment the rats were sacrificed and brain acetylcholinesterase level was estimated. Administration of aluminium chloride resulted in poor learning and memory and this was significantly reversed by rivastigmine and metformin. In conclusion, the memory impairment induced by aluminum chloride was revered significantly by both rivastigmine and metformin.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalJournal of Global Pharma Technology
Volume9
Issue number1
Publication statusPublished - 2017

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Rivastigmine
Metformin
Alzheimer Disease
Wistar Rats
Learning
Acetylcholinesterase
Water
Brain
aluminum chloride

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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Metformin attenuates cognitive deficits in experimentally induced Alzheimer's disease. / Dash, Devasrita; Chogtu, Bharti; Kurady, Laxmianarayana Bairy.

In: Journal of Global Pharma Technology, Vol. 9, No. 1, 2017, p. 8-12.

Research output: Contribution to journalArticle

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