Metformin for lithium-induced weight gain: A case report

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Lithium is the first line treatment for maintenance treatment of bipolar disorder. Among the long term adverse effects, weight gain is likely to affect a subset of patients. There is no specific guideline for the treatment of lithium-induced weight gain. We report a young male with bipolar disorder who had significant weight gain with lithium (25 kg), which responded to metformin treatment at 500 mg twice daily. The proposed mechanism of weight lowering effect of metformin includes changes in hypothalamic physiology, including leptin and insulin sensitivity, as well as circadian rhythm changes affecting food intake, regulation of fat oxidation and storage in liver, skeletal muscle, and adipose tissue.

Original languageEnglish
Pages (from-to)101-103
Number of pages3
JournalClinical Psychopharmacology and Neuroscience
Volume14
Issue number1
DOIs
Publication statusPublished - 01-01-2016

Fingerprint

Metformin
Lithium
Weight Gain
Bipolar Disorder
Appetite Regulation
Therapeutics
Circadian Rhythm
Leptin
Insulin Resistance
Adipose Tissue
Skeletal Muscle
Fats
Guidelines
Weights and Measures
Muscles
Liver

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Pharmacology (medical)

Cite this

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Metformin for lithium-induced weight gain : A case report. / Praharaj, Samir Kumar.

In: Clinical Psychopharmacology and Neuroscience, Vol. 14, No. 1, 01.01.2016, p. 101-103.

Research output: Contribution to journalArticle

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