TY - JOUR
T1 - Methotrexate-loaded biodegradable nanoparticles: Preparation, characterization and evaluation of its cytotoxic potential against U-343 MGa human neuronal glioblastoma cells
AU - Musmade, Kranti P.
AU - Deshpande, Praful B.
AU - Musmade, Prashant B.
AU - Maliyakkal, M. Naseer
AU - Kumar, A. Ranjith
AU - Reddy, M. Sreenivasa
AU - Udupa, N.
N1 - cited By 2
PY - 2014
Y1 - 2014
N2 - Nanoparticles represent one of the attractive alternatives in the effective treatment of cancer chemotherapy. In the present work, formulation and development of a novel methotrexate (MTX)-loaded biodegradable nanoparticles using poly(D,L-lactide-co-glycolide) (PLGA) was carried out. The prepared nanoparticles were evaluated for physicochemical properties such as particle size, zeta potential, release studies, etc and also evaluated for its in vitro cytotoxic potential against U-343 MGa human neuronal glioblastoma cells. Particle size of optimized formulation was < 200 nm. There was a considerable decrease in cell viability and enhancement in cytotoxic activity of MTX-loaded nanoparticles compared to MTX alone when tested against U-343 MGa human neuronal glioblastoma cells.
AB - Nanoparticles represent one of the attractive alternatives in the effective treatment of cancer chemotherapy. In the present work, formulation and development of a novel methotrexate (MTX)-loaded biodegradable nanoparticles using poly(D,L-lactide-co-glycolide) (PLGA) was carried out. The prepared nanoparticles were evaluated for physicochemical properties such as particle size, zeta potential, release studies, etc and also evaluated for its in vitro cytotoxic potential against U-343 MGa human neuronal glioblastoma cells. Particle size of optimized formulation was < 200 nm. There was a considerable decrease in cell viability and enhancement in cytotoxic activity of MTX-loaded nanoparticles compared to MTX alone when tested against U-343 MGa human neuronal glioblastoma cells.
UR - http://www.scopus.com/inward/record.url?scp=84903286868&partnerID=8YFLogxK
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M3 - Article
AN - SCOPUS:84903286868
SN - 0250-4707
VL - 37
SP - 945
EP - 951
JO - Bulletin of Materials Science
JF - Bulletin of Materials Science
IS - 4
ER -
