Methotrexate loaded chitosan and chitin microspheres - In vitro characterization and pharmacokinetics in mice bearing Ehrlich ascites carcinoma

U.V. Singh, N. Udupa

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Methotrexate (MTX) loaded chitosan and chitin microspheres were prepared. The physicochemical characteristics were affected by various parameters, e.g. stirring speed, concentration of chitosan and chitin. The t(1/2) for in vitro release varied depending on the concentration of chitosan and chitin and the amount of glutaraldehyde used. The antitumour activity in Ehrlich ascites tumour bearing mice for MTX loaded chitosan microspheres was better when compared with plane MTX on oral administration. The plasma drug levels were sustained.

Original languageEnglish
Pages (from-to)581-594
Number of pages14
JournalJournal of Microencapsulation
Issue number5
Publication statusPublished - 1998


All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

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