Metronomic therapy for malignant peripheral nerve sheath tumor in neurofibromatosis type 1

Narendra Chaudhary, Anupama Borker

Research output: Contribution to journalArticle

5 Citations (Scopus)


Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive tumor especially in the patients with neurofibromatosis type 1 (NF1). Without a complete surgical excision, prognosis is guarded. We describe a 10-year-old male with NF1 with MPNST, who had a local relapse within 5 weeks of surgical excision. Chemoradiotherapy did not result in tumor regression. Initiation of palliative oral metronomic therapy resulted in complete remission after six cycles. The patient continues to be in remission, 20 months after completion of nine cycles of metronomic therapy. Metronomic therapy may be effective in MPNST where conventional chemotherapy and radiotherapy fails.

Original languageEnglish
Pages (from-to)1317-1319
Number of pages3
JournalPediatric Blood and Cancer
Issue number7
Publication statusPublished - 15-12-2012
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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