Microneedle: A effective and safe tool for drug delivery

P. Shivanand, P. Binal, R. Mahalaxmi, D. Viral, N.P. Jivani

Research output: Contribution to journalArticle

Abstract

Microneedle-based vaccination with the current anthrax vaccine produced an equally effective immune response to intramuscular injection in rabbits using smaller dosage say researcher from Maryland and North Carolina. In the study researchers compared the efficacy of immunizing rabbits with the current anthrax vaccine intradermally using a microneedle and intramuscularly using a conventional needle. Results showed that intradermal delivery required less dosage to induce similar antibody levels as those seen following intramuscular injection. Rabbits that were administered the vaccine using the microneedle-based technique showed protection against inhalation anthrax at 100%, while those vaccinated using conventional methods were protected at 71%.
Original languageEnglish
Pages (from-to)1283-1286
Number of pages4
JournalInternational Journal of PharmTech Research
Volume1
Issue number4
Publication statusPublished - 2009

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Anthrax Vaccines
Intramuscular Injections
Rabbits
Research Personnel
Pharmaceutical Preparations
Needles
Vaccination
Vaccines
Antibodies

Cite this

Shivanand, P., Binal, P., Mahalaxmi, R., Viral, D., & Jivani, N. P. (2009). Microneedle: A effective and safe tool for drug delivery. International Journal of PharmTech Research, 1(4), 1283-1286.
Shivanand, P. ; Binal, P. ; Mahalaxmi, R. ; Viral, D. ; Jivani, N.P. / Microneedle: A effective and safe tool for drug delivery. In: International Journal of PharmTech Research. 2009 ; Vol. 1, No. 4. pp. 1283-1286.
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author = "P. Shivanand and P. Binal and R. Mahalaxmi and D. Viral and N.P. Jivani",
note = "Export Date: 10 November 2017 Correspondence Address: Shivanand, P.; Smt. R. B. P. M. Pharmacy College, Atkot-360040, Rajkot, Gujarat, India; email: dot.shivanand@gmail.com Chemicals/CAS: glucose, 50-99-7, 84778-64-3 References: Murphy, C.S., Prausnitz, M.R., (1991) Silicone Hair Spray Compositions, , US Patent No. 4,983,377. International patents issued or pending in European Patent Office and 11 other countries; Langer, R., Peppas, N.A., Advances in Biomaterials, Drug Delivery, and Bionanotechnology (2003) AIChE Journal, 49 (12), pp. 2990-3006. , DOI 10.1002/aic.690491202; Chen, J., Wise, K.D., Hetke, J.F., Bledsoe Jr., S.C., A multichannel neural probe for selective chemical delivery at the cellular level (1997) IEEE Transactions on Biomedical Engineering, 44 (8), pp. 760-769. , DOI 10.1109/10.605435, PII S0018929497053548; Reed, M.L., Clarence, W., James, K., Watkins, S., Vorp, D.A., Nadeem, A., Weiss, L.E., Feldman, M.D., Micromechanical devices for intravascular drug delivery (1998) J. Pharm. Sci., 87, pp. 1387-1394; McAllister, Allen, D.V., Prausnitz, M.G., R, M., Microfabricated microneedles for gene and drug delivery (2000) Annu. Rev. Biomed. Eng., 2, pp. 289-313; Trimmer, W., Ling, P., Chin, C.K., Orten, P., Gaugler, R., Hashmi, S., Hashmi, G., Reed, M., Injection of DNA into plant and animal tissues with micromechanical piercing structures (1995) Proceedings of the IEEE Microelectromechanical Systems Workshop 8th, pp. 111-115. , Amsterdam; Zachary Hilt, J., Nicholas, A., (2005) Peppas Microfabricated Drug Delivery Devices International Journal of Pharmaceutics, 306, pp. 15-23; Meidan Victor, M., Michniak Bozena, B., Emerging Technologies in Transdermal Therapeutics (2004) American Journal of Therapeutics, 11 (4), pp. 312-316",
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Shivanand, P, Binal, P, Mahalaxmi, R, Viral, D & Jivani, NP 2009, 'Microneedle: A effective and safe tool for drug delivery', International Journal of PharmTech Research, vol. 1, no. 4, pp. 1283-1286.

Microneedle: A effective and safe tool for drug delivery. / Shivanand, P.; Binal, P.; Mahalaxmi, R.; Viral, D.; Jivani, N.P.

In: International Journal of PharmTech Research, Vol. 1, No. 4, 2009, p. 1283-1286.

Research output: Contribution to journalArticle

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