Micronuclei-induction and its correlation to cell survival in HeLa cells treated with different doses of adriamycin

Ganesh Chandra Jagetia, Vijayashree Nayak

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Abstract

The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 μg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival were found to be inversely related.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalCancer Letters
Volume110
Issue number1-2
DOIs
Publication statusPublished - 20-12-1996
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Molecular Biology
  • Oncology

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