Micronuclei-induction and its correlation to cell survival in HeLa cells treated with different doses of adriamycin

Ganesh Chandra Jagetia, Vijayashree Nayak

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 μg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival were found to be inversely related.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalCancer Letters
Volume110
Issue number1-2
DOIs
Publication statusPublished - 20-12-1996
Externally publishedYes

Fingerprint

HeLa Cells
Doxorubicin
Cell Survival

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Jagetia, Ganesh Chandra ; Nayak, Vijayashree. / Micronuclei-induction and its correlation to cell survival in HeLa cells treated with different doses of adriamycin. In: Cancer Letters. 1996 ; Vol. 110, No. 1-2. pp. 123-128.
@article{8ea1f4db5345471d8af071e08187bc86,
title = "Micronuclei-induction and its correlation to cell survival in HeLa cells treated with different doses of adriamycin",
abstract = "The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 μg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival were found to be inversely related.",
author = "Jagetia, {Ganesh Chandra} and Vijayashree Nayak",
year = "1996",
month = "12",
day = "20",
doi = "10.1016/S0304-3835(96)04470-9",
language = "English",
volume = "110",
pages = "123--128",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

Micronuclei-induction and its correlation to cell survival in HeLa cells treated with different doses of adriamycin. / Jagetia, Ganesh Chandra; Nayak, Vijayashree.

In: Cancer Letters, Vol. 110, No. 1-2, 20.12.1996, p. 123-128.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Micronuclei-induction and its correlation to cell survival in HeLa cells treated with different doses of adriamycin

AU - Jagetia, Ganesh Chandra

AU - Nayak, Vijayashree

PY - 1996/12/20

Y1 - 1996/12/20

N2 - The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 μg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival were found to be inversely related.

AB - The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 μg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival were found to be inversely related.

UR - http://www.scopus.com/inward/record.url?scp=0030596162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030596162&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(96)04470-9

DO - 10.1016/S0304-3835(96)04470-9

M3 - Article

C2 - 9018090

AN - SCOPUS:0030596162

VL - 110

SP - 123

EP - 128

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1-2

ER -