Microwave-assisted and conventional synthesis of benzothieno [3,2-e] [1,3,4] triazolo[4,3-c]pyrimidines

A comparative study

Research output: Contribution to journalArticle

Abstract

Benzothieno[2,3-d]pyrimidines (2,3,4) and benzothieno[3,2-e][1,3,4] triazolo[4,3-c] pyrimidines (5a-c) were synthesized from the precursor 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 by employing the conventional method as well as the microwave irradiation technique. The precursor 2-amino-3-cyanothiophene analogue 1 was synthesized by employing the well-known Gewald reaction. In the present work it has been found that the microwave supported syntheses are more efficient than the conventional classical heating methods. The structures of all the compounds were ascertained by spectral and analytical data.

Original languageEnglish
Pages (from-to)388-392
Number of pages5
JournalJournal of the Korean Chemical Society
Volume58
Issue number4
DOIs
Publication statusPublished - 20-08-2014

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Pyrimidines
Microwave irradiation
Microwaves
Heating
benzothiophene

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Chemistry (miscellaneous)

Cite this

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title = "Microwave-assisted and conventional synthesis of benzothieno [3,2-e] [1,3,4] triazolo[4,3-c]pyrimidines: A comparative study",
abstract = "Benzothieno[2,3-d]pyrimidines (2,3,4) and benzothieno[3,2-e][1,3,4] triazolo[4,3-c] pyrimidines (5a-c) were synthesized from the precursor 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 by employing the conventional method as well as the microwave irradiation technique. The precursor 2-amino-3-cyanothiophene analogue 1 was synthesized by employing the well-known Gewald reaction. In the present work it has been found that the microwave supported syntheses are more efficient than the conventional classical heating methods. The structures of all the compounds were ascertained by spectral and analytical data.",
author = "Gaonkar, {Santhosh L.} and Chuljin Ahn and Princia and Shetty, {Nitinkumar S.}",
year = "2014",
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language = "English",
volume = "58",
pages = "388--392",
journal = "Journal of the Korean Chemical Society",
issn = "1017-2548",
publisher = "Korean Chemical Society",
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TY - JOUR

T1 - Microwave-assisted and conventional synthesis of benzothieno [3,2-e] [1,3,4] triazolo[4,3-c]pyrimidines

T2 - A comparative study

AU - Gaonkar, Santhosh L.

AU - Ahn, Chuljin

AU - Princia,

AU - Shetty, Nitinkumar S.

PY - 2014/8/20

Y1 - 2014/8/20

N2 - Benzothieno[2,3-d]pyrimidines (2,3,4) and benzothieno[3,2-e][1,3,4] triazolo[4,3-c] pyrimidines (5a-c) were synthesized from the precursor 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 by employing the conventional method as well as the microwave irradiation technique. The precursor 2-amino-3-cyanothiophene analogue 1 was synthesized by employing the well-known Gewald reaction. In the present work it has been found that the microwave supported syntheses are more efficient than the conventional classical heating methods. The structures of all the compounds were ascertained by spectral and analytical data.

AB - Benzothieno[2,3-d]pyrimidines (2,3,4) and benzothieno[3,2-e][1,3,4] triazolo[4,3-c] pyrimidines (5a-c) were synthesized from the precursor 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 by employing the conventional method as well as the microwave irradiation technique. The precursor 2-amino-3-cyanothiophene analogue 1 was synthesized by employing the well-known Gewald reaction. In the present work it has been found that the microwave supported syntheses are more efficient than the conventional classical heating methods. The structures of all the compounds were ascertained by spectral and analytical data.

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U2 - 10.5012/jkcs.2014.58.4.388

DO - 10.5012/jkcs.2014.58.4.388

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EP - 392

JO - Journal of the Korean Chemical Society

JF - Journal of the Korean Chemical Society

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