Microwave-assisted and conventional synthesis of benzothieno [3,2-e] [1,3,4] triazolo[4,3-c]pyrimidines: A comparative study

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Benzothieno[2,3-d]pyrimidines (2,3,4) and benzothieno[3,2-e][1,3,4] triazolo[4,3-c] pyrimidines (5a-c) were synthesized from the precursor 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 by employing the conventional method as well as the microwave irradiation technique. The precursor 2-amino-3-cyanothiophene analogue 1 was synthesized by employing the well-known Gewald reaction. In the present work it has been found that the microwave supported syntheses are more efficient than the conventional classical heating methods. The structures of all the compounds were ascertained by spectral and analytical data.

Original languageEnglish
Pages (from-to)388-392
Number of pages5
JournalJournal of the Korean Chemical Society
Issue number4
Publication statusPublished - 20-08-2014


All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Chemistry (miscellaneous)

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