Microwave-assisted solvent-free synthesis of N-alkyl benzotriazole derivatives: Antimicrobial studies

Raghu Ningegowda, C. V. Kavitha, B. S. Priya, S. L. Gaonkar, M. V. Tejesvi, K. S. Rangappa, S. Nanjunda Swamy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To elucidate further our structural activity relation on the chemistry and antimicrobial activity, a series of novel N-alkylated benzotriazole derivatives bearing pharmaceutically important substituted biphenyl and benzyl halides were synthesized. The synthesized compounds were characterized and tested for in vitro antimicrobial activities by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms. The synthesis has been carried out using microwave irradiation method with solvent and without solvent. The obtained results showed high yields. Interestingly, compounds 2a and 2b showed a two fold increased antibacterial activity than the standard drug tested and the compounds 2d and 2e showed potent antifungal activity than the standard drug tested.

Original languageEnglish
Pages (from-to)502-507
Number of pages6
JournalLetters in Drug Design and Discovery
Volume6
Issue number7
DOIs
Publication statusPublished - 10-2009

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Microwaves
Pharmaceutical Preparations
benzotriazole
diphenyl
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Ningegowda, Raghu ; Kavitha, C. V. ; Priya, B. S. ; Gaonkar, S. L. ; Tejesvi, M. V. ; Rangappa, K. S. ; Swamy, S. Nanjunda. / Microwave-assisted solvent-free synthesis of N-alkyl benzotriazole derivatives : Antimicrobial studies. In: Letters in Drug Design and Discovery. 2009 ; Vol. 6, No. 7. pp. 502-507.
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Microwave-assisted solvent-free synthesis of N-alkyl benzotriazole derivatives : Antimicrobial studies. / Ningegowda, Raghu; Kavitha, C. V.; Priya, B. S.; Gaonkar, S. L.; Tejesvi, M. V.; Rangappa, K. S.; Swamy, S. Nanjunda.

In: Letters in Drug Design and Discovery, Vol. 6, No. 7, 10.2009, p. 502-507.

Research output: Contribution to journalArticle

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AU - Ningegowda, Raghu

AU - Kavitha, C. V.

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