Microwave-assisted synthesis and evaluation of anti-inflammatory activity of new series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives

S. L. Gaonkar, K. M. Lokanatha Rai, N. Suchetha Shetty

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives bearing potentially bioactive substituents were synthesized by microwave irradiation method in good yield compared with conventional method. The synthesized compounds were screened for their anti-inflammatory activity and were compared with a standard drug. The compounds demonstrated potent to weak anti-inflammatory activity. Of the compounds studied, compounds 6i and 6d showed potent activity comparable to the standard drug ibuprofen at the same dose in carrageenan-induced paw edema in rat model.

Original languageEnglish
Pages (from-to)221-230
Number of pages10
JournalMedicinal Chemistry Research
Volume18
Issue number3
DOIs
Publication statusPublished - 03-2009

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Microwaves
Anti-Inflammatory Agents
Bearings (structural)
Derivatives
Microwave irradiation
Carrageenan
Ibuprofen
Pharmaceutical Preparations
Rats
Edema
imidazole

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

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abstract = "A series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives bearing potentially bioactive substituents were synthesized by microwave irradiation method in good yield compared with conventional method. The synthesized compounds were screened for their anti-inflammatory activity and were compared with a standard drug. The compounds demonstrated potent to weak anti-inflammatory activity. Of the compounds studied, compounds 6i and 6d showed potent activity comparable to the standard drug ibuprofen at the same dose in carrageenan-induced paw edema in rat model.",
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Microwave-assisted synthesis and evaluation of anti-inflammatory activity of new series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives. / Gaonkar, S. L.; Lokanatha Rai, K. M.; Suchetha Shetty, N.

In: Medicinal Chemistry Research, Vol. 18, No. 3, 03.2009, p. 221-230.

Research output: Contribution to journalArticle

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