Microwave-assisted synthesis of the antihyperglycemic drug rosiglitazone

Santosh L. Gaonkar, Hiroki Shimizu

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We developed a simple, rapid, high yielding, and environmentally benign microwave assisted total synthesis of rosiglitazone, an antihyperglycemic agent for diabetes mellitus Type II. We used microwave heating successfully to improve reactions in four of six steps and obtain quicker and higher yields. In addition, all intermediates were isolated in good yields with crystallizations only and did not require chromatographic separations.

Original languageEnglish
Pages (from-to)3314-3317
Number of pages4
JournalTetrahedron
Volume66
Issue number18
DOIs
Publication statusPublished - 01-05-2010

Fingerprint

rosiglitazone
Microwave heating
Medical problems
Microwaves
Crystallization
Hypoglycemic Agents
Pharmaceutical Preparations
Heating
Type 2 Diabetes Mellitus

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Gaonkar, Santosh L. ; Shimizu, Hiroki. / Microwave-assisted synthesis of the antihyperglycemic drug rosiglitazone. In: Tetrahedron. 2010 ; Vol. 66, No. 18. pp. 3314-3317.
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Microwave-assisted synthesis of the antihyperglycemic drug rosiglitazone. / Gaonkar, Santosh L.; Shimizu, Hiroki.

In: Tetrahedron, Vol. 66, No. 18, 01.05.2010, p. 3314-3317.

Research output: Contribution to journalArticle

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