Microwave-induced synthesis of schiff bases of aminothiazolyl bromocoumarins as antibacterials

K. Venugopala, B. Jayashree

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

A fast and highly efficient method for the synthesis of some of the schiff bases of aminothiazolylbromocoumarin (4a-m) has been performed by microwave irradiation of 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole (3) and substituted aromatic aldehydes (a-m). Microwave assisted reactions have resulted in better yields of the desired products than when prepared under conventional conditions. The resulting products were evaluated for their qualitative and quantitative antibacterial activity.
Original languageEnglish
Pages (from-to)88-91
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume70
Issue number1
DOIs
Publication statusPublished - 2008

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Schiff Bases
Microwaves
Thiazoles
Aldehydes

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title = "Microwave-induced synthesis of schiff bases of aminothiazolyl bromocoumarins as antibacterials",
abstract = "A fast and highly efficient method for the synthesis of some of the schiff bases of aminothiazolylbromocoumarin (4a-m) has been performed by microwave irradiation of 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole (3) and substituted aromatic aldehydes (a-m). Microwave assisted reactions have resulted in better yields of the desired products than when prepared under conventional conditions. The resulting products were evaluated for their qualitative and quantitative antibacterial activity.",
author = "K. Venugopala and B. Jayashree",
note = "Cited By :46 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Venugopala, K.; Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore - 560 027, India; email: venugopalakn@gmail.com Chemicals/CAS: ampicillin, 69-52-3, 69-53-4, 7177-48-2, 74083-13-9, 94586-58-0 References: Kennedy, R.O., Thornes, R.D., (1997) Coumarins: Biology, Applications and mode of action, pp. 155-157. , Chichester: Wiley and Sons;; Venugopala, K.N., Jayashree, B.S., Synthesis and characterization of carboxamides of 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole for their analgesic and antiinflammatory activity (2003) Indian J Heterocyclic Chem, 12, pp. 307-310; Venugopala, K.N., Jayashree, B.S., Synthesis and characterization of schiff bases of aminothiazolyl bromocoumarin for their Analgesic and Antiinflammatory activity (2004) Asian J Chem, 16, pp. 407-411; Min, J., Jiaxing, H., Weiyi, H., Hongwen, H., Synthesis of some new 3-coumarinyl coumarin oximes and related cyclization products derived from 3-acetyl coumarin (2001) Indian J Chem, 40, pp. 1223-1225; Kashman, Y., Kirk, R., Gustafson, R.W., Fuller 2nd, J.H., McMahon, J.B., Currens, M.J., HIV inhibitory natural products. Part 7. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum (1993) J Med Chem, 36, p. 1110; Bourinbaiar, A.S., Tan, X., Nagorny, R., Inhibitory effect of coumarins on HIV-1 replication and cell-mediated or cell-free viral transmission (1993) Acta Virol, 37, pp. 241-250; Kavanagh, F., (1963) Analytical Microbiology, pp. 125-127. , New York: Academic Press;; Lowdin, E., Odenholt-Tornqvist, I., Bengtsson, S., Cars, O., A new method to determine the postantibiotic effect and the effects of subinhibitory antibiotic concentrations (1993) Antimicrob Agents Chemother, 37, pp. 2200-2205",
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Microwave-induced synthesis of schiff bases of aminothiazolyl bromocoumarins as antibacterials. / Venugopala, K.; Jayashree, B.

In: Indian Journal of Pharmaceutical Sciences, Vol. 70, No. 1, 2008, p. 88-91.

Research output: Contribution to journalArticle

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T1 - Microwave-induced synthesis of schiff bases of aminothiazolyl bromocoumarins as antibacterials

AU - Venugopala, K.

AU - Jayashree, B.

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PY - 2008

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N2 - A fast and highly efficient method for the synthesis of some of the schiff bases of aminothiazolylbromocoumarin (4a-m) has been performed by microwave irradiation of 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole (3) and substituted aromatic aldehydes (a-m). Microwave assisted reactions have resulted in better yields of the desired products than when prepared under conventional conditions. The resulting products were evaluated for their qualitative and quantitative antibacterial activity.

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DO - 10.4103/0250-474X.40338

M3 - Article

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SN - 0250-474X

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