TY - JOUR
T1 - MiRNA-146a polymorphism was not associated with malaria in southern India
AU - van Loon, Welmoed
AU - Gai, Prabhanjan P.
AU - Kulkarni, Suyamindra S.
AU - Rasalkar, Rashmi
AU - Siegert, Konrad
AU - Wedam, Jakob
AU - Boloor, Archith
AU - Baliga, Shantaram
AU - Kumar, Arun
AU - Jain, Animesh
AU - Mahabala, Chakrapani
AU - Shenoy, Damodara
AU - Devi, Rajeshwari
AU - Gai, Pramod
AU - Mockenhaupt, Frank P.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Micro-RNAs (miRNAs) play a crucial role in immune regulation, and a common miRNA-146a polymorphism (rs2910164) increased the odds of falciparum malaria in pregnant African women. Here, we examined whether this association holds true in a different population, that is, 449 mainly male and adult malaria patients and 666 community controls in southwestern India. Plasmodium vivax malaria (67%) predominated over falciparum malaria (11%) and mixed species infections (22%). Overall, 59% of the study participants carried the miRNA-146a polymorphism. However, it was not associated with the odds of malaria, irrespective of parasite species. This underlines the importance of considering the complexities of clinical manifestations of malaria, genetic background, and parasite species when disentangling the role of human genetic variation, including those of miRNAs in malaria.
AB - Micro-RNAs (miRNAs) play a crucial role in immune regulation, and a common miRNA-146a polymorphism (rs2910164) increased the odds of falciparum malaria in pregnant African women. Here, we examined whether this association holds true in a different population, that is, 449 mainly male and adult malaria patients and 666 community controls in southwestern India. Plasmodium vivax malaria (67%) predominated over falciparum malaria (11%) and mixed species infections (22%). Overall, 59% of the study participants carried the miRNA-146a polymorphism. However, it was not associated with the odds of malaria, irrespective of parasite species. This underlines the importance of considering the complexities of clinical manifestations of malaria, genetic background, and parasite species when disentangling the role of human genetic variation, including those of miRNAs in malaria.
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U2 - 10.4269/AJTMH.19-0845
DO - 10.4269/AJTMH.19-0845
M3 - Article
C2 - 32124721
AN - SCOPUS:85085382308
SN - 0002-9637
VL - 102
SP - 1072
EP - 1074
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -
