Models for assessing the role of selenoproteins in health

Mohamed E. Moustafa, Easwari Kumaraswamy, Nianxin Zhong, Mahadev Rao, Bradley A. Carlson, Dolph L. Hatfield

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Two model systems for examining the role of selenoproteins in health are discussed. One utilizes transgenic mice that carry mutant selenocysteine (Sec) tRNA transgenes that result in the reduction of selenoprotein expression in a protein- and tissue-specific manner. The other utilizes loxP-Cre technology to selectively remove the Sec tRNA gene in mammary epithelium that results in the reduction of only certain selenoproteins in this tissue. Both approaches provide important tools for examining the role of selenoproteins in health.

Original languageEnglish
JournalJournal of Nutrition
Volume133
Issue number7 SUPPL.
Publication statusPublished - 01-07-2003

Fingerprint

Selenoproteins
Health
Transgenes
Transgenic Mice
Breast
Epithelium
Technology
Genes
Proteins
selenocysteinyl-tRNA

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Moustafa, M. E., Kumaraswamy, E., Zhong, N., Rao, M., Carlson, B. A., & Hatfield, D. L. (2003). Models for assessing the role of selenoproteins in health. Journal of Nutrition, 133(7 SUPPL.).
Moustafa, Mohamed E. ; Kumaraswamy, Easwari ; Zhong, Nianxin ; Rao, Mahadev ; Carlson, Bradley A. ; Hatfield, Dolph L. / Models for assessing the role of selenoproteins in health. In: Journal of Nutrition. 2003 ; Vol. 133, No. 7 SUPPL.
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Moustafa, ME, Kumaraswamy, E, Zhong, N, Rao, M, Carlson, BA & Hatfield, DL 2003, 'Models for assessing the role of selenoproteins in health', Journal of Nutrition, vol. 133, no. 7 SUPPL..

Models for assessing the role of selenoproteins in health. / Moustafa, Mohamed E.; Kumaraswamy, Easwari; Zhong, Nianxin; Rao, Mahadev; Carlson, Bradley A.; Hatfield, Dolph L.

In: Journal of Nutrition, Vol. 133, No. 7 SUPPL., 01.07.2003.

Research output: Contribution to journalArticle

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AU - Hatfield, Dolph L.

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Moustafa ME, Kumaraswamy E, Zhong N, Rao M, Carlson BA, Hatfield DL. Models for assessing the role of selenoproteins in health. Journal of Nutrition. 2003 Jul 1;133(7 SUPPL.).