Abstract
Two model systems for examining the role of selenoproteins in health are discussed. One utilizes transgenic mice that carry mutant selenocysteine (Sec) tRNA transgenes that result in the reduction of selenoprotein expression in a protein- and tissue-specific manner. The other utilizes loxP-Cre technology to selectively remove the Sec tRNA gene in mammary epithelium that results in the reduction of only certain selenoproteins in this tissue. Both approaches provide important tools for examining the role of selenoproteins in health.
| Original language | English |
|---|---|
| Journal | Journal of Nutrition |
| Volume | 133 |
| Issue number | 7 SUPPL. |
| Publication status | Published - 01-07-2003 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Nutrition and Dietetics
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Models for assessing the role of selenoproteins in health. / Moustafa, Mohamed E.; Kumaraswamy, Easwari; Zhong, Nianxin; Rao, Mahadev; Carlson, Bradley A.; Hatfield, Dolph L.
In: Journal of Nutrition, Vol. 133, No. 7 SUPPL., 01.07.2003.Research output: Contribution to journal › Article
TY - JOUR
T1 - Models for assessing the role of selenoproteins in health
AU - Moustafa, Mohamed E.
AU - Kumaraswamy, Easwari
AU - Zhong, Nianxin
AU - Rao, Mahadev
AU - Carlson, Bradley A.
AU - Hatfield, Dolph L.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Two model systems for examining the role of selenoproteins in health are discussed. One utilizes transgenic mice that carry mutant selenocysteine (Sec) tRNA transgenes that result in the reduction of selenoprotein expression in a protein- and tissue-specific manner. The other utilizes loxP-Cre technology to selectively remove the Sec tRNA gene in mammary epithelium that results in the reduction of only certain selenoproteins in this tissue. Both approaches provide important tools for examining the role of selenoproteins in health.
AB - Two model systems for examining the role of selenoproteins in health are discussed. One utilizes transgenic mice that carry mutant selenocysteine (Sec) tRNA transgenes that result in the reduction of selenoprotein expression in a protein- and tissue-specific manner. The other utilizes loxP-Cre technology to selectively remove the Sec tRNA gene in mammary epithelium that results in the reduction of only certain selenoproteins in this tissue. Both approaches provide important tools for examining the role of selenoproteins in health.
UR - http://www.scopus.com/inward/record.url?scp=0037999973&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037999973&partnerID=8YFLogxK
M3 - Article
C2 - 12840229
AN - SCOPUS:0037999973
VL - 133
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 7 SUPPL.
ER -