Models for assessing the role of selenoproteins in health

Mohamed E. Moustafa, Easwari Kumaraswamy, Nianxin Zhong, Mahadev Rao, Bradley A. Carlson, Dolph L. Hatfield

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Abstract

Two model systems for examining the role of selenoproteins in health are discussed. One utilizes transgenic mice that carry mutant selenocysteine (Sec) tRNA transgenes that result in the reduction of selenoprotein expression in a protein- and tissue-specific manner. The other utilizes loxP-Cre technology to selectively remove the Sec tRNA gene in mammary epithelium that results in the reduction of only certain selenoproteins in this tissue. Both approaches provide important tools for examining the role of selenoproteins in health.

Original languageEnglish
JournalJournal of Nutrition
Volume133
Issue number7 SUPPL.
Publication statusPublished - 01-07-2003

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Moustafa, M. E., Kumaraswamy, E., Zhong, N., Rao, M., Carlson, B. A., & Hatfield, D. L. (2003). Models for assessing the role of selenoproteins in health. Journal of Nutrition, 133(7 SUPPL.).