Modulation of doxorubicin-induced genotoxicity by Aegle marmelos in mouse bone marrow

A micronucleus study

Ponemone Venkatesh, Bellary Shantala, Ganesh Chandra Jagetia, K. Koteshwer Rao, Manjeshwar Shrinath Baliga

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The effect of various concentrations of Aegle marmelos (AME) on the doxorubicin (DOX)-induced genotoxic effects in mice bone marrow was studied. Treatment of mice with different concentrations of DOX resulted in a dose-dependent elevation in the frequency of micronucleated polychromatic (MPCE) as well as normochromatic (MNCE) erythrocytes in mouse bone marrow. The frequencies of MPCE and MNCE increased with scoring time, and the greatest elevation for MPCE was observed at 48 hours post-DOX treatment, whereas a maximum increase in MNCE was observed at 72 hours post-DOX treatment. This increase in MPCE and MNCE was accompanied by a decline in the polychromatic erythrocytes-normochromatic erythrocytes (PCE/NCE) ratio, which showed a DOX-dose-dependent decline. Treatment of mice with 200, 250, 300, 350, and 400 mg/kg body weight of AME, orally once daily for 5 consecutive days before DOX treatment, significantly reduced the frequency of DOX-induced micronuclei accompanied by a significant elevation in the PCE/NCE ratio at all scoring times. The greatest protection against DOX-induced genotoxicity was observed at 350 mg/kg AME. The protection against DOX-induced genotoxicity by AME may be due to inhibition of free radicals and increased antioxidant status.

Original languageEnglish
Pages (from-to)42-53
Number of pages12
JournalIntegrative Cancer Therapies
Volume6
Issue number1
DOIs
Publication statusPublished - 01-03-2007
Externally publishedYes

Fingerprint

Aegle
Doxorubicin
Bone Marrow
Erythrocytes
Free Radicals
Antioxidants
Body Weight

All Science Journal Classification (ASJC) codes

  • Oncology
  • Complementary and alternative medicine

Cite this

Venkatesh, Ponemone ; Shantala, Bellary ; Jagetia, Ganesh Chandra ; Rao, K. Koteshwer ; Baliga, Manjeshwar Shrinath. / Modulation of doxorubicin-induced genotoxicity by Aegle marmelos in mouse bone marrow : A micronucleus study. In: Integrative Cancer Therapies. 2007 ; Vol. 6, No. 1. pp. 42-53.
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Modulation of doxorubicin-induced genotoxicity by Aegle marmelos in mouse bone marrow : A micronucleus study. / Venkatesh, Ponemone; Shantala, Bellary; Jagetia, Ganesh Chandra; Rao, K. Koteshwer; Baliga, Manjeshwar Shrinath.

In: Integrative Cancer Therapies, Vol. 6, No. 1, 01.03.2007, p. 42-53.

Research output: Contribution to journalArticle

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